FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372333359> ?p ?o ?g. }

• W4372333359 abstract "Health-related quality of life (HRQoL) and vulnerability are variably affected in patients with myelodysplastic syndromes (MDS) and other cytopenic states; however, the heterogeneous composition of these diseases has limited our understanding of these domains. The NHLBI-sponsored MDS Natural History Study (NCT02775383) is a prospective cohort enrolling patients undergoing diagnostic work up for suspected MDS or MDS/myeloproliferative neoplasms (MPNs) in the setting of cytopenias. Untreated patients undergo bone marrow assessment with central histopathology review for assignment as MDS, MDS/MPN, idiopathic cytopenia of undetermined significance (ICUS), acute myeloid leukemia (AML) with &lt;30% blasts, and At-Risk. HRQoL data are collected at enrollment including MDS-specific (QUALMS) and general (e.g., PROMIS Fatigue) instruments. Dichotomized vulnerability is assessed with the VES-13. Baseline HRQoL scores from 449 patients with MDS (n=248), MDS/MPN (n=40), AML&lt;30% (n=15), ICUS (n=48), or At-Risk (n=98) were similar among diagnoses. In MDS, HRQoL was worse for vulnerable participants (e.g., mean PROMIS Fatigue of 56.0 vs. 49.5; p&lt;0.001) and those with worse prognosis (e.g., mean EQ-5D-5L of 73.4, 72.7, and 64.1 for low, intermediate, and high-risk disease; p=0.005). In vulnerable MDS participants (n=84), most had difficulty with prolonged physical activity (88%) such as walking a quarter mile (74%). These data suggest that cytopenias leading to MDS evaluation are associated with similar HRQoL-regardless of eventual diagnosis-with worse HRQoL among the vulnerable. Among those with MDS, lower-risk disease was associated with better HRQoL, but the relationship was lost among the vulnerable, showing for the first time that vulnerability trumps disease risk in affecting HRQoL." @default.
• W4372333359 created "2023-05-07" @default.
• W4372333359 creator A5002289370 @default.
• W4372333359 creator A5008717243 @default.
• W4372333359 creator A5010962133 @default.
• W4372333359 creator A5025342328 @default.
• W4372333359 creator A5035051206 @default.
• W4372333359 creator A5035609080 @default.
• W4372333359 creator A5035621912 @default.
• W4372333359 creator A5037725540 @default.
• W4372333359 creator A5039180386 @default.
• W4372333359 creator A5041319498 @default.
• W4372333359 creator A5041754278 @default.
• W4372333359 creator A5051728469 @default.
• W4372333359 creator A5052920087 @default.
• W4372333359 creator A5054065134 @default.
• W4372333359 creator A5055163444 @default.
• W4372333359 creator A5055740968 @default.
• W4372333359 creator A5058862489 @default.
• W4372333359 creator A5062252471 @default.
• W4372333359 creator A5090831668 @default.
• W4372333359 creator A5091710463 @default.
• W4372333359 date "2023-05-05" @default.
• W4372333359 modified "2023-10-02" @default.
• W4372333359 title "Health-Related Quality of Life and Vulnerability among People with Myelodysplastic Syndromes: A US National Study" @default.
• W4372333359 cites W1485309286 @default.
• W4372333359 cites W187238933 @default.
• W4372333359 cites W1950000646 @default.
• W4372333359 cites W1979144446 @default.
• W4372333359 cites W1990166011 @default.
• W4372333359 cites W2058473727 @default.
• W4372333359 cites W2105258029 @default.
• W4372333359 cites W2107336306 @default.
• W4372333359 cites W2108397210 @default.
• W4372333359 cites W2117326858 @default.
• W4372333359 cites W2162420979 @default.
• W4372333359 cites W2287042406 @default.
• W4372333359 cites W2297856459 @default.
• W4372333359 cites W2326726820 @default.
• W4372333359 cites W2606218280 @default.
• W4372333359 cites W2724252873 @default.
• W4372333359 cites W2770907544 @default.
• W4372333359 cites W2774428646 @default.
• W4372333359 cites W2793680327 @default.
• W4372333359 cites W2804780558 @default.
• W4372333359 cites W2946362137 @default.
• W4372333359 cites W2962406727 @default.
• W4372333359 cites W2979434443 @default.
• W4372333359 cites W2992237925 @default.
• W4372333359 cites W2993594890 @default.
• W4372333359 cites W3081310922 @default.
• W4372333359 cites W3153964554 @default.
• W4372333359 cites W3164281877 @default.
• W4372333359 cites W3166443714 @default.
• W4372333359 cites W3182365126 @default.
• W4372333359 cites W4311934766 @default.
• W4372333359 doi "https://doi.org/10.1182/bloodadvances.2022009000" @default.
• W4372333359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37146263" @default.
• W4372333359 hasPublicationYear "2023" @default.
• W4372333359 type Work @default.
• W4372333359 citedByCount "1" @default.
• W4372333359 countsByYear W43723333592023 @default.
• W4372333359 crossrefType "journal-article" @default.
• W4372333359 hasAuthorship W4372333359A5002289370 @default.
• W4372333359 hasAuthorship W4372333359A5008717243 @default.
• W4372333359 hasAuthorship W4372333359A5010962133 @default.
• W4372333359 hasAuthorship W4372333359A5025342328 @default.
• W4372333359 hasAuthorship W4372333359A5035051206 @default.
• W4372333359 hasAuthorship W4372333359A5035609080 @default.
• W4372333359 hasAuthorship W4372333359A5035621912 @default.
• W4372333359 hasAuthorship W4372333359A5037725540 @default.
• W4372333359 hasAuthorship W4372333359A5039180386 @default.
• W4372333359 hasAuthorship W4372333359A5041319498 @default.
• W4372333359 hasAuthorship W4372333359A5041754278 @default.
• W4372333359 hasAuthorship W4372333359A5051728469 @default.
• W4372333359 hasAuthorship W4372333359A5052920087 @default.
• W4372333359 hasAuthorship W4372333359A5054065134 @default.
• W4372333359 hasAuthorship W4372333359A5055163444 @default.
• W4372333359 hasAuthorship W4372333359A5055740968 @default.
• W4372333359 hasAuthorship W4372333359A5058862489 @default.
• W4372333359 hasAuthorship W4372333359A5062252471 @default.
• W4372333359 hasAuthorship W4372333359A5090831668 @default.
• W4372333359 hasAuthorship W4372333359A5091710463 @default.
• W4372333359 hasBestOaLocation W43723333591 @default.
• W4372333359 hasConcept C126322002 @default.
• W4372333359 hasConcept C159110408 @default.
• W4372333359 hasConcept C1862650 @default.
• W4372333359 hasConcept C2779951463 @default.
• W4372333359 hasConcept C2780007613 @default.
• W4372333359 hasConcept C2780366003 @default.
• W4372333359 hasConcept C2780817109 @default.
• W4372333359 hasConcept C71924100 @default.
• W4372333359 hasConcept C72563966 @default.
• W4372333359 hasConceptScore W4372333359C126322002 @default.
• W4372333359 hasConceptScore W4372333359C159110408 @default.
• W4372333359 hasConceptScore W4372333359C1862650 @default.
• W4372333359 hasConceptScore W4372333359C2779951463 @default.
• W4372333359 hasConceptScore W4372333359C2780007613 @default.
• W4372333359 hasConceptScore W4372333359C2780366003 @default.
• W4372333359 hasConceptScore W4372333359C2780817109 @default.

• next