FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372335798> ?p ?o ?g. }

• W4372335798 abstract "One of the hallmarks of cancer is metastasis, a process that entails the spread of cancer cells to distant regions in the body, culminating in tumor formation in secondary organs. Importantly, the proinflammatory environment surrounding cancer cells further contributes to cancer cell transformation and extracellular matrix destruction. During metastasis, front-rear polarity and emergence of migratory and invasive features are manifestations of epithelial-mesenchymal transition (EMT). A variety of transcription factors (TFs) are implicated in the execution of EMT, the most prominent belonging to the Snail Family Transcriptional Repressor (SNAI) and Zinc Finger E-Box Binding Homeobox (ZEB) families of TFs. These TFs are regulated by interaction with specific microRNAs (miRNAs), as miR34 and miR200. Among the several secondary metabolites produced in plants, flavonoids constitute a major group of bioactive molecules, with several described effects including antioxidant, antiinflammatory, antidiabetic, antiobesogenic, and anticancer effects. This review scrutinizes the modulatory role of flavonoids on the activity of SNAI/ZEB TFs and on their regulatory miRNAs, miR-34, and miR-200. The modulatory role of flavonoids can attenuate mesenchymal features and stimulate epithelial features, thereby inhibiting and reversing EMT. Moreover, this modulation is concomitant with the attenuation of signaling pathways involved in diverse processes as cell proliferation, cell growth, cell cycle progression, apoptosis inhibition, morphogenesis, cell fate, cell migration, cell polarity, and wound healing. The antimetastatic potential of these versatile compounds is emerging and represents an opportunity for the synthesis of more specific and potent agents." @default.
• W4372335798 created "2023-05-07" @default.
• W4372335798 creator A5007525286 @default.
• W4372335798 creator A5009571169 @default.
• W4372335798 creator A5030103481 @default.
• W4372335798 creator A5077989534 @default.
• W4372335798 creator A5084618730 @default.
• W4372335798 creator A5091050812 @default.
• W4372335798 date "2023-05-05" @default.
• W4372335798 modified "2023-10-05" @default.
• W4372335798 title "The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis" @default.
• W4372335798 cites W1558187819 @default.
• W4372335798 cites W1648293707 @default.
• W4372335798 cites W1804495077 @default.
• W4372335798 cites W1832612490 @default.
• W4372335798 cites W1849856438 @default.
• W4372335798 cites W1933244249 @default.
• W4372335798 cites W1963501822 @default.
• W4372335798 cites W1964189009 @default.
• W4372335798 cites W1965805525 @default.
• W4372335798 cites W1967828043 @default.
• W4372335798 cites W1970098795 @default.
• W4372335798 cites W1972346116 @default.
• W4372335798 cites W1974016804 @default.
• W4372335798 cites W1974241074 @default.
• W4372335798 cites W1978878974 @default.
• W4372335798 cites W1980484515 @default.
• W4372335798 cites W1981930609 @default.
• W4372335798 cites W1986466971 @default.
• W4372335798 cites W1987275335 @default.
• W4372335798 cites W1998203489 @default.
• W4372335798 cites W2006169733 @default.
• W4372335798 cites W2006796770 @default.
• W4372335798 cites W2015100090 @default.
• W4372335798 cites W2015463086 @default.
• W4372335798 cites W2026140964 @default.
• W4372335798 cites W2028593825 @default.
• W4372335798 cites W2029409898 @default.
• W4372335798 cites W2035396934 @default.
• W4372335798 cites W2041602966 @default.
• W4372335798 cites W2044512261 @default.
• W4372335798 cites W2051081114 @default.
• W4372335798 cites W2053883832 @default.
• W4372335798 cites W2054318449 @default.
• W4372335798 cites W2061843980 @default.
• W4372335798 cites W2064921823 @default.
• W4372335798 cites W2068255220 @default.
• W4372335798 cites W2082419651 @default.
• W4372335798 cites W2085718006 @default.
• W4372335798 cites W2087861588 @default.
• W4372335798 cites W2090345205 @default.
• W4372335798 cites W2093719136 @default.
• W4372335798 cites W2098891057 @default.
• W4372335798 cites W2099870162 @default.
• W4372335798 cites W2104546896 @default.
• W4372335798 cites W2104551938 @default.
• W4372335798 cites W2111226655 @default.
• W4372335798 cites W2111541751 @default.
• W4372335798 cites W2117263216 @default.
• W4372335798 cites W2129242642 @default.
• W4372335798 cites W2133708523 @default.
• W4372335798 cites W2144169031 @default.
• W4372335798 cites W2146457049 @default.
• W4372335798 cites W2156092992 @default.
• W4372335798 cites W2157220550 @default.
• W4372335798 cites W2170242482 @default.
• W4372335798 cites W2176847520 @default.
• W4372335798 cites W2177744475 @default.
• W4372335798 cites W2217868403 @default.
• W4372335798 cites W2222093206 @default.
• W4372335798 cites W2225115505 @default.
• W4372335798 cites W2258324256 @default.
• W4372335798 cites W2289315746 @default.
• W4372335798 cites W2301690319 @default.
• W4372335798 cites W2312603117 @default.
• W4372335798 cites W2323272702 @default.
• W4372335798 cites W2340445357 @default.
• W4372335798 cites W2341148711 @default.
• W4372335798 cites W2342750377 @default.
• W4372335798 cites W2346168689 @default.
• W4372335798 cites W2395708137 @default.
• W4372335798 cites W2400307281 @default.
• W4372335798 cites W2419558864 @default.
• W4372335798 cites W2460906374 @default.
• W4372335798 cites W2461689898 @default.
• W4372335798 cites W2475360213 @default.
• W4372335798 cites W2487275113 @default.
• W4372335798 cites W2490723858 @default.
• W4372335798 cites W2507610324 @default.
• W4372335798 cites W2508829436 @default.
• W4372335798 cites W2511456693 @default.
• W4372335798 cites W2520632143 @default.
• W4372335798 cites W2522630089 @default.
• W4372335798 cites W2529267350 @default.
• W4372335798 cites W2531986144 @default.
• W4372335798 cites W2559916255 @default.
• W4372335798 cites W2567682222 @default.
• W4372335798 cites W2569366849 @default.
• W4372335798 cites W2570763587 @default.
• W4372335798 cites W2584942793 @default.

• next