Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372335887> ?p ?o ?g. }
- W4372335887 abstract "Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, and immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients with SCZ or BD versus healthy controls (HC). We analyzed microarray-based global gene expression data in whole blood from a cohort of SCZ (N = 329), BD (N = 203) and HC (N = 189). In total, 65 genes were significantly differentially expressed in SCZ and 125 in BD, as compared to HC, with similar ratio of up- and downregulated genes in both disorders. Among the top differentially expressed genes, we found an innate immunity signature that was shared between SCZ and BD, consisting of a cluster of upregulated genes (e.g., OLFM4, ELANE, BPI and MPO) that indicate an increased fraction of immature neutrophils. Several of these genes displayed sex differences in the expression pattern, and post-hoc analysis demonstrated a positive correlation with triglyceride and a negative correlation with HDL cholesterol. We found that many of the downregulated genes in SCZ and BD were associated with smoking. These findings of neutrophil granulocyte-associated transcriptome signatures in both SCZ and BD point at altered innate immunity pathways with association to lipid changes and potential for clinical translation." @default.
- W4372335887 created "2023-05-07" @default.
- W4372335887 creator A5012669547 @default.
- W4372335887 creator A5032257154 @default.
- W4372335887 creator A5038692125 @default.
- W4372335887 creator A5050243253 @default.
- W4372335887 creator A5052826567 @default.
- W4372335887 creator A5055292325 @default.
- W4372335887 creator A5064324947 @default.
- W4372335887 creator A5067512211 @default.
- W4372335887 creator A5067512311 @default.
- W4372335887 creator A5071025171 @default.
- W4372335887 creator A5088646325 @default.
- W4372335887 creator A5090087019 @default.
- W4372335887 date "2023-05-05" @default.
- W4372335887 modified "2023-09-27" @default.
- W4372335887 title "Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes" @default.
- W4372335887 cites W14181867 @default.
- W4372335887 cites W1906444297 @default.
- W4372335887 cites W1918724965 @default.
- W4372335887 cites W1967267265 @default.
- W4372335887 cites W1984344128 @default.
- W4372335887 cites W1991875060 @default.
- W4372335887 cites W1996254162 @default.
- W4372335887 cites W1999400773 @default.
- W4372335887 cites W2004638361 @default.
- W4372335887 cites W2035979460 @default.
- W4372335887 cites W2036891888 @default.
- W4372335887 cites W2040789766 @default.
- W4372335887 cites W2042755650 @default.
- W4372335887 cites W2050256938 @default.
- W4372335887 cites W2050584458 @default.
- W4372335887 cites W2053142936 @default.
- W4372335887 cites W2060312436 @default.
- W4372335887 cites W2060845434 @default.
- W4372335887 cites W2073061970 @default.
- W4372335887 cites W2075199575 @default.
- W4372335887 cites W2076166404 @default.
- W4372335887 cites W2082279387 @default.
- W4372335887 cites W2088012555 @default.
- W4372335887 cites W2089030570 @default.
- W4372335887 cites W2093098541 @default.
- W4372335887 cites W2102181001 @default.
- W4372335887 cites W2102296619 @default.
- W4372335887 cites W2106608030 @default.
- W4372335887 cites W2118373398 @default.
- W4372335887 cites W2133766549 @default.
- W4372335887 cites W2134108978 @default.
- W4372335887 cites W2138694950 @default.
- W4372335887 cites W2142415307 @default.
- W4372335887 cites W2143136226 @default.
- W4372335887 cites W2146512944 @default.
- W4372335887 cites W2154926042 @default.
- W4372335887 cites W2161894245 @default.
- W4372335887 cites W2171037992 @default.
- W4372335887 cites W2173409373 @default.
- W4372335887 cites W2296142757 @default.
- W4372335887 cites W2337092408 @default.
- W4372335887 cites W2344070856 @default.
- W4372335887 cites W2399060753 @default.
- W4372335887 cites W2500955566 @default.
- W4372335887 cites W2510734833 @default.
- W4372335887 cites W2513841576 @default.
- W4372335887 cites W2549976854 @default.
- W4372335887 cites W2551102722 @default.
- W4372335887 cites W2556709183 @default.
- W4372335887 cites W2578607799 @default.
- W4372335887 cites W2586669042 @default.
- W4372335887 cites W2587440168 @default.
- W4372335887 cites W2596984373 @default.
- W4372335887 cites W2647963547 @default.
- W4372335887 cites W2745116209 @default.
- W4372335887 cites W2789913340 @default.
- W4372335887 cites W2797349527 @default.
- W4372335887 cites W2810929521 @default.
- W4372335887 cites W2884942447 @default.
- W4372335887 cites W2887714075 @default.
- W4372335887 cites W2894955961 @default.
- W4372335887 cites W2902152106 @default.
- W4372335887 cites W2939605277 @default.
- W4372335887 cites W2943047044 @default.
- W4372335887 cites W2945822310 @default.
- W4372335887 cites W2965225112 @default.
- W4372335887 cites W2970478205 @default.
- W4372335887 cites W2982167270 @default.
- W4372335887 cites W2995971356 @default.
- W4372335887 cites W3027045903 @default.
- W4372335887 cites W3029502789 @default.
- W4372335887 cites W3041506758 @default.
- W4372335887 cites W3109834777 @default.
- W4372335887 cites W3134326326 @default.
- W4372335887 cites W3162259891 @default.
- W4372335887 cites W3194167281 @default.
- W4372335887 cites W3195923108 @default.
- W4372335887 cites W3198467537 @default.
- W4372335887 cites W4205669829 @default.
- W4372335887 cites W4210674280 @default.
- W4372335887 cites W4211069648 @default.
- W4372335887 cites W4211145950 @default.
- W4372335887 cites W4223520055 @default.