FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372337057> ?p ?o ?g. }

• W4372337057 abstract "People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD) independent of cigarette smoking. We hypothesized that dysbiosis in PLWH is associated with epigenetic and transcriptomic disruptions in the airway epithelium.Airway epithelial brushings were collected from 18 COPD + HIV + , 16 COPD - HIV + , 22 COPD + HIV - and 20 COPD - HIV - subjects. The microbiome, methylome, and transcriptome were profiled using 16S sequencing, Illumina Infinium Methylation EPIC chip, and RNA sequencing, respectively. Multi 'omic integration was performed using Data Integration Analysis for Biomarker discovery using Latent cOmponents. A correlation > 0.7 was used to identify key interactions between the 'omes.The COPD + HIV -, COPD -HIV + , and COPD + HIV + groups had reduced Shannon Diversity (p = 0.004, p = 0.023, and p = 5.5e-06, respectively) compared to individuals with neither COPD nor HIV, with the COPD + HIV + group demonstrating the most reduced diversity. Microbial communities were significantly different between the four groups (p = 0.001). Multi 'omic integration identified correlations between Bacteroidetes Prevotella, genes FUZ, FASTKD3, and ACVR1B, and epigenetic features CpG-FUZ and CpG-PHLDB3.PLWH with COPD manifest decreased diversity and altered microbial communities in their airway epithelial microbiome. The reduction in Prevotella in this group was linked with epigenetic and transcriptomic disruptions in host genes including FUZ, FASTKD3, and ACVR1B." @default.
• W4372337057 created "2023-05-07" @default.
• W4372337057 creator A5002766825 @default.
• W4372337057 creator A5008394020 @default.
• W4372337057 creator A5013908616 @default.
• W4372337057 creator A5021602288 @default.
• W4372337057 creator A5022928428 @default.
• W4372337057 creator A5027937292 @default.
• W4372337057 creator A5031481818 @default.
• W4372337057 creator A5037708178 @default.
• W4372337057 creator A5042188739 @default.
• W4372337057 creator A5042635009 @default.
• W4372337057 creator A5044744589 @default.
• W4372337057 creator A5044820853 @default.
• W4372337057 creator A5059355777 @default.
• W4372337057 creator A5061614395 @default.
• W4372337057 creator A5067787766 @default.
• W4372337057 creator A5069396293 @default.
• W4372337057 creator A5071511946 @default.
• W4372337057 creator A5073767847 @default.
• W4372337057 creator A5073967383 @default.
• W4372337057 creator A5074441717 @default.
• W4372337057 creator A5076569498 @default.
• W4372337057 creator A5081023683 @default.
• W4372337057 creator A5084140210 @default.
• W4372337057 date "2023-05-04" @default.
• W4372337057 modified "2023-10-17" @default.
• W4372337057 title "Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling" @default.
• W4372337057 cites W1793747226 @default.
• W4372337057 cites W1931450175 @default.
• W4372337057 cites W1968604451 @default.
• W4372337057 cites W1969359874 @default.
• W4372337057 cites W2000210076 @default.
• W4372337057 cites W2026667514 @default.
• W4372337057 cites W2055962849 @default.
• W4372337057 cites W2061575742 @default.
• W4372337057 cites W2062632981 @default.
• W4372337057 cites W2074207296 @default.
• W4372337057 cites W2092960278 @default.
• W4372337057 cites W2099449365 @default.
• W4372337057 cites W2124918753 @default.
• W4372337057 cites W2131186249 @default.
• W4372337057 cites W2142800258 @default.
• W4372337057 cites W2149200050 @default.
• W4372337057 cites W2150283886 @default.
• W4372337057 cites W2169706086 @default.
• W4372337057 cites W2272836689 @default.
• W4372337057 cites W2286863291 @default.
• W4372337057 cites W2319179640 @default.
• W4372337057 cites W2410574180 @default.
• W4372337057 cites W2515699201 @default.
• W4372337057 cites W2735980669 @default.
• W4372337057 cites W2768522228 @default.
• W4372337057 cites W2782585946 @default.
• W4372337057 cites W2785692071 @default.
• W4372337057 cites W2883188821 @default.
• W4372337057 cites W2897210781 @default.
• W4372337057 cites W2898695685 @default.
• W4372337057 cites W2909472027 @default.
• W4372337057 cites W2921574129 @default.
• W4372337057 cites W3015660580 @default.
• W4372337057 cites W3042757970 @default.
• W4372337057 cites W3135187242 @default.
• W4372337057 cites W3153303509 @default.
• W4372337057 cites W3173875945 @default.
• W4372337057 cites W3178362123 @default.
• W4372337057 cites W3207265153 @default.
• W4372337057 cites W4224062633 @default.
• W4372337057 doi "https://doi.org/10.1186/s12931-023-02431-4" @default.
• W4372337057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37143066" @default.
• W4372337057 hasPublicationYear "2023" @default.
• W4372337057 type Work @default.
• W4372337057 citedByCount "0" @default.
• W4372337057 crossrefType "journal-article" @default.
• W4372337057 hasAuthorship W4372337057A5002766825 @default.
• W4372337057 hasAuthorship W4372337057A5008394020 @default.
• W4372337057 hasAuthorship W4372337057A5013908616 @default.
• W4372337057 hasAuthorship W4372337057A5021602288 @default.
• W4372337057 hasAuthorship W4372337057A5022928428 @default.
• W4372337057 hasAuthorship W4372337057A5027937292 @default.
• W4372337057 hasAuthorship W4372337057A5031481818 @default.
• W4372337057 hasAuthorship W4372337057A5037708178 @default.
• W4372337057 hasAuthorship W4372337057A5042188739 @default.
• W4372337057 hasAuthorship W4372337057A5042635009 @default.
• W4372337057 hasAuthorship W4372337057A5044744589 @default.
• W4372337057 hasAuthorship W4372337057A5044820853 @default.
• W4372337057 hasAuthorship W4372337057A5059355777 @default.
• W4372337057 hasAuthorship W4372337057A5061614395 @default.
• W4372337057 hasAuthorship W4372337057A5067787766 @default.
• W4372337057 hasAuthorship W4372337057A5069396293 @default.
• W4372337057 hasAuthorship W4372337057A5071511946 @default.
• W4372337057 hasAuthorship W4372337057A5073767847 @default.
• W4372337057 hasAuthorship W4372337057A5073967383 @default.
• W4372337057 hasAuthorship W4372337057A5074441717 @default.
• W4372337057 hasAuthorship W4372337057A5076569498 @default.
• W4372337057 hasAuthorship W4372337057A5081023683 @default.
• W4372337057 hasAuthorship W4372337057A5084140210 @default.
• W4372337057 hasBestOaLocation W43723370571 @default.
• W4372337057 hasConcept C104317684 @default.
• W4372337057 hasConcept C126322002 @default.

• next