FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372338357> ?p ?o ?g. }

• W4372338357 abstract "Abstract Background Many biochemical, immunological, and neuropsychiatric changes are associated with end-stage renal disease (ESRD). Neuronal damage biomarkers such as glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), S100 calcium-binding protein B (S100B), ionized calcium-binding adaptor molecule-1 (IBA1), and myelin basic protein (MBP) are among the less-studied biomarkers of ESRD. Aim We examined the associations between these neuro-axis biomarkers, inflammatory biomarkers, e.g., C-reactive protein (CRP), interleukin (IL-6), IL-10, and zinc, copper, and neuropsychiatric symptoms due to ERSD. Methods ELISA techniques were used to measure serum levels of neuronal damage biomarkers in 70 ESRD patients, and 46 healthy controls. Results ESRD patients have higher scores of depression, anxiety, fatigue, and physiosomatic symptoms than healthy controls. Aberrations in kidney function tests and the number of dialysis interventions are associated with the severity of depression, anxiety, fibro-fatigue and physiosomatic symptoms, peripheral inflammation, nestin, and NFL. Serum levels of neuronal damage biomarkers (NFL, MBP, and nestin), CRP, and interleukin (IL)-10 are elevated, and serum zinc is decreased in ESRD patients as compared with controls. The neuronal damage biomarkers NFL, nestin, S100B and MBP are associated with the severity of one or more neuropsychiatric symptom domains. Around 50% of the variance in the neuropsychiatric symptoms is explained by NFL, nestin, S00B, copper, and an inflammatory index. Conclusions The severity of renal dysfunction and/or the number of dialysis interventions may induce peripheral inflammation and, consequently, neurotoxicity to intermediate filament proteins, astrocytes, and the blood-brain barrier, leading to the neuropsychiatric symptoms of ESRD." @default.
• W4372338357 created "2023-05-07" @default.
• W4372338357 creator A5002270558 @default.
• W4372338357 creator A5051970614 @default.
• W4372338357 creator A5057796094 @default.
• W4372338357 creator A5081924790 @default.
• W4372338357 creator A5087239345 @default.
• W4372338357 date "2023-05-05" @default.
• W4372338357 modified "2023-09-27" @default.
• W4372338357 title "Neuronal damage and inflammatory biomarkers are associated with the affective and chronic fatigue-like symptoms due to end-stage renal disease" @default.
• W4372338357 cites W1799577004 @default.
• W4372338357 cites W1918841475 @default.
• W4372338357 cites W1965933264 @default.
• W4372338357 cites W1970798179 @default.
• W4372338357 cites W1976622086 @default.
• W4372338357 cites W1979814348 @default.
• W4372338357 cites W1983286296 @default.
• W4372338357 cites W2005610476 @default.
• W4372338357 cites W2008786641 @default.
• W4372338357 cites W2011553061 @default.
• W4372338357 cites W2040786733 @default.
• W4372338357 cites W2044981871 @default.
• W4372338357 cites W2053876965 @default.
• W4372338357 cites W2071789497 @default.
• W4372338357 cites W2076641476 @default.
• W4372338357 cites W2082888555 @default.
• W4372338357 cites W2097969657 @default.
• W4372338357 cites W2098722533 @default.
• W4372338357 cites W2146105386 @default.
• W4372338357 cites W2152271789 @default.
• W4372338357 cites W2153830290 @default.
• W4372338357 cites W2155441599 @default.
• W4372338357 cites W2160070901 @default.
• W4372338357 cites W2165958715 @default.
• W4372338357 cites W2166216415 @default.
• W4372338357 cites W2578467211 @default.
• W4372338357 cites W2598364092 @default.
• W4372338357 cites W2601196285 @default.
• W4372338357 cites W2734587042 @default.
• W4372338357 cites W2792944588 @default.
• W4372338357 cites W2883074143 @default.
• W4372338357 cites W2895668342 @default.
• W4372338357 cites W2900872097 @default.
• W4372338357 cites W2914765137 @default.
• W4372338357 cites W2942192422 @default.
• W4372338357 cites W2968485766 @default.
• W4372338357 cites W2970676275 @default.
• W4372338357 cites W3002588492 @default.
• W4372338357 cites W3012284818 @default.
• W4372338357 cites W3018597088 @default.
• W4372338357 cites W3024585410 @default.
• W4372338357 cites W3034494256 @default.
• W4372338357 cites W3042437593 @default.
• W4372338357 cites W3098760744 @default.
• W4372338357 cites W3168146572 @default.
• W4372338357 cites W3169783027 @default.
• W4372338357 cites W3196311686 @default.
• W4372338357 cites W3207092986 @default.
• W4372338357 cites W4220734151 @default.
• W4372338357 cites W4225604015 @default.
• W4372338357 cites W4300468006 @default.
• W4372338357 cites W4317806651 @default.
• W4372338357 cites W4319758617 @default.
• W4372338357 cites W4320888780 @default.
• W4372338357 cites W4361271472 @default.
• W4372338357 cites W4362712253 @default.
• W4372338357 doi "https://doi.org/10.1101/2023.05.03.23289492" @default.
• W4372338357 hasPublicationYear "2023" @default.
• W4372338357 type Work @default.
• W4372338357 citedByCount "0" @default.
• W4372338357 crossrefType "posted-content" @default.
• W4372338357 hasAuthorship W4372338357A5002270558 @default.
• W4372338357 hasAuthorship W4372338357A5051970614 @default.
• W4372338357 hasAuthorship W4372338357A5057796094 @default.
• W4372338357 hasAuthorship W4372338357A5081924790 @default.
• W4372338357 hasAuthorship W4372338357A5087239345 @default.
• W4372338357 hasBestOaLocation W43723383571 @default.
• W4372338357 hasConcept C126322002 @default.
• W4372338357 hasConcept C142724271 @default.
• W4372338357 hasConcept C204232928 @default.
• W4372338357 hasConcept C2776914184 @default.
• W4372338357 hasConcept C2779134260 @default.
• W4372338357 hasConcept C2780495277 @default.
• W4372338357 hasConcept C2781197716 @default.
• W4372338357 hasConcept C3019040382 @default.
• W4372338357 hasConcept C55493867 @default.
• W4372338357 hasConcept C71924100 @default.
• W4372338357 hasConcept C86803240 @default.
• W4372338357 hasConceptScore W4372338357C126322002 @default.
• W4372338357 hasConceptScore W4372338357C142724271 @default.
• W4372338357 hasConceptScore W4372338357C204232928 @default.
• W4372338357 hasConceptScore W4372338357C2776914184 @default.
• W4372338357 hasConceptScore W4372338357C2779134260 @default.
• W4372338357 hasConceptScore W4372338357C2780495277 @default.
• W4372338357 hasConceptScore W4372338357C2781197716 @default.
• W4372338357 hasConceptScore W4372338357C3019040382 @default.
• W4372338357 hasConceptScore W4372338357C55493867 @default.
• W4372338357 hasConceptScore W4372338357C71924100 @default.
• W4372338357 hasConceptScore W4372338357C86803240 @default.
• W4372338357 hasLocation W43723383571 @default.

• next