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- W4372342967 endingPage "101233" @default.
- W4372342967 startingPage "101233" @default.
- W4372342967 abstract "Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific population of proteins that varies according to the location and function of each LD. Over the past decade, there have been significant advances in the understanding of LD biogenesis and functions. LDs are now recognized as dynamic organelles that participate in many aspects of cellular homeostasis plus other vital functions. LD biogenesis is a complex, highly-regulated process with assembly occurring on the endoplasmic reticulum although aspects of the underpinning molecular mechanisms remain elusive. For example, it is unclear how many enzymes participate in the biosynthesis of the neutral lipid components of LDs and how this process is coordinated in response to different metabolic cues to promote or suppress LD formation and turnover. In addition to enzymes involved in the biosynthesis of neutral lipids, various scaffolding proteins play roles in coordinating LD formation. Despite their lack of ultrastructural diversity, LDs in different mammalian cell types are involved in a wide range of biological functions. These include roles in membrane homeostasis, regulation of hypoxia, neoplastic inflammatory responses, cellular oxidative status, lipid peroxidation, and protection against potentially toxic intracellular fatty acids and lipophilic xenobiotics. Herein, the roles of mammalian LDs and their associated proteins are reviewed with a particular focus on their roles in pathological, immunological and anti-toxicological processes." @default.
- W4372342967 created "2023-05-07" @default.
- W4372342967 creator A5043839209 @default.
- W4372342967 creator A5055010496 @default.
- W4372342967 creator A5066472178 @default.
- W4372342967 creator A5090447354 @default.
- W4372342967 date "2023-07-01" @default.
- W4372342967 modified "2023-09-25" @default.
- W4372342967 title "Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles" @default.
- W4372342967 cites W1485927957 @default.
- W4372342967 cites W1493048246 @default.
- W4372342967 cites W1502020403 @default.
- W4372342967 cites W1548584275 @default.
- W4372342967 cites W1550747483 @default.
- W4372342967 cites W1593931056 @default.
- W4372342967 cites W1606948338 @default.
- W4372342967 cites W1618386398 @default.
- W4372342967 cites W1629308315 @default.
- W4372342967 cites W1648506109 @default.
- W4372342967 cites W1699517970 @default.
- W4372342967 cites W1706150252 @default.
- W4372342967 cites W1820136232 @default.
- W4372342967 cites W1840670308 @default.
- W4372342967 cites W1844898587 @default.
- W4372342967 cites W1854421050 @default.
- W4372342967 cites W1905318621 @default.
- W4372342967 cites W1908352934 @default.
- W4372342967 cites W1923917571 @default.
- W4372342967 cites W1942089699 @default.
- W4372342967 cites W1963956807 @default.
- W4372342967 cites W1965792495 @default.
- W4372342967 cites W1968531757 @default.
- W4372342967 cites W1968628675 @default.
- W4372342967 cites W1969754220 @default.
- W4372342967 cites W1969989200 @default.
- W4372342967 cites W1970606002 @default.
- W4372342967 cites W1970989628 @default.
- W4372342967 cites W1972449427 @default.
- W4372342967 cites W1973738451 @default.
- W4372342967 cites W1974730258 @default.
- W4372342967 cites W1974974158 @default.
- W4372342967 cites W1975229775 @default.
- W4372342967 cites W1977180164 @default.
- W4372342967 cites W1977689678 @default.
- W4372342967 cites W1978093763 @default.
- W4372342967 cites W1978611201 @default.
- W4372342967 cites W1978921042 @default.
- W4372342967 cites W1979122274 @default.
- W4372342967 cites W1981366938 @default.
- W4372342967 cites W1982075308 @default.
- W4372342967 cites W1982679356 @default.
- W4372342967 cites W1985156966 @default.
- W4372342967 cites W1986318660 @default.
- W4372342967 cites W1986958303 @default.
- W4372342967 cites W1989652805 @default.
- W4372342967 cites W1989847959 @default.
- W4372342967 cites W1990768419 @default.
- W4372342967 cites W1992522828 @default.
- W4372342967 cites W1992639059 @default.
- W4372342967 cites W1993334744 @default.
- W4372342967 cites W1993465904 @default.
- W4372342967 cites W1993824052 @default.
- W4372342967 cites W1994668150 @default.
- W4372342967 cites W1994802782 @default.
- W4372342967 cites W1995541025 @default.
- W4372342967 cites W1997238838 @default.
- W4372342967 cites W1997436728 @default.
- W4372342967 cites W1999438839 @default.
- W4372342967 cites W1999898913 @default.
- W4372342967 cites W2000002411 @default.
- W4372342967 cites W2002232196 @default.
- W4372342967 cites W2002733746 @default.
- W4372342967 cites W2003188273 @default.
- W4372342967 cites W2006251119 @default.
- W4372342967 cites W2007199806 @default.
- W4372342967 cites W2007442417 @default.
- W4372342967 cites W2010130739 @default.
- W4372342967 cites W2011185005 @default.
- W4372342967 cites W2011197197 @default.
- W4372342967 cites W2011647937 @default.
- W4372342967 cites W2012004008 @default.
- W4372342967 cites W2012875419 @default.
- W4372342967 cites W2013090884 @default.
- W4372342967 cites W2013521084 @default.
- W4372342967 cites W2014714133 @default.
- W4372342967 cites W2014858941 @default.
- W4372342967 cites W2015012139 @default.
- W4372342967 cites W2015671992 @default.
- W4372342967 cites W2017477539 @default.
- W4372342967 cites W2017914244 @default.
- W4372342967 cites W2019665740 @default.
- W4372342967 cites W2019913278 @default.
- W4372342967 cites W2019981157 @default.
- W4372342967 cites W2021964673 @default.
- W4372342967 cites W2022274174 @default.
- W4372342967 cites W2023422813 @default.
- W4372342967 cites W2023430066 @default.
- W4372342967 cites W2023863977 @default.