Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372348944> ?p ?o ?g. }
- W4372348944 abstract "Abstract Keratin intermediate filaments form strong mechanical scaffolds that confer structural stability to epithelial tissues, but the reason this function requires a protein family with fifty-four isoforms is not understood. During skin wound healing, a shift in keratin isoform expression alters the composition of keratin filaments. How this change modulates cellular function to support epidermal remodeling remains unclear. We report an unexpected effect of keratin isoform variation on kinase signal transduction. Increased expression of woundassociated keratin 6A, but not of steady-state keratin 5, potentiated keratinocyte migration and wound closure without compromising epidermal stability by activating myosin motors. This pathway depended on isoform-specific interaction between intrinsically disordered keratin head domains and non-filamentous vimentin shuttling myosin-activating kinases. These results substantially expand the functional repertoire of intermediate filaments from their canonical role as mechanical scaffolds to include roles as signaling scaffolds that spatiotemporally organize signal transduction cascades depending on isoform composition." @default.
- W4372348944 created "2023-05-07" @default.
- W4372348944 creator A5006550760 @default.
- W4372348944 creator A5017035954 @default.
- W4372348944 creator A5023633176 @default.
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- W4372348944 creator A5037958980 @default.
- W4372348944 creator A5043215799 @default.
- W4372348944 creator A5091697058 @default.
- W4372348944 date "2023-05-05" @default.
- W4372348944 modified "2023-10-15" @default.
- W4372348944 title "Keratin isoform shifts modulate motility signals during wound healing" @default.
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