Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372355013> ?p ?o ?g. }
- W4372355013 abstract "Abstract Purpose The incidence of acute myocardial infarctions (AMI) shows circadian variation typically peaking during morning hours with a decline at night. However, this variation does not occur in patients with diabetes mellitus (DM). The night’s decline of AMI may be partially explained by melatonin-related platelet inhibition. Whether this effect is absent in diabetic patients is unknown. The aim was to study the effect of melatonin on in-vitro platelet aggregation in healthy individuals and patients with type 2 DM. Methods Platelet aggregation was measured in blood samples from healthy individuals ( n = 15) and type 2 DM patients ( n = 15) using multiple electrode aggregometry. Adenosine diphosphate (ADP), arachidonic acid (ASPI) and thrombin (TRAP) were used as agonists. Aggregability for each subject was tested after adding melatonin in two concentrations. Results In healthy individuals, melatonin inhibited platelet aggregation in both higher (10–5 M) and lower concentrations (10–9 M) induced by ADP, ASPI, and TRAP ( p < 0.001, p = 0.002, p = 0.029, respectively). In DM patients, melatonin did not affect platelet aggregation in both concentrations induced by ADP, ASPI, and TRAP. Melatonin decreased platelet aggregation induced by ADP, ASPI, and TRAP significantly more in healthy individuals compared to patients with DM. ( p = 0.005, p = 0.045 and p = 0.048, respectively). Conclusion Platelet aggregation was inhibited by melatonin in healthy individuals. In-vitro antiplatelet effect of melatonin in type 2 DM patients is significantly attenuated." @default.
- W4372355013 created "2023-05-07" @default.
- W4372355013 creator A5007650341 @default.
- W4372355013 creator A5012697290 @default.
- W4372355013 creator A5016305753 @default.
- W4372355013 creator A5025251556 @default.
- W4372355013 creator A5031384737 @default.
- W4372355013 creator A5031730926 @default.
- W4372355013 creator A5044687162 @default.
- W4372355013 creator A5050312824 @default.
- W4372355013 creator A5059819092 @default.
- W4372355013 creator A5062276099 @default.
- W4372355013 creator A5075985473 @default.
- W4372355013 creator A5086881397 @default.
- W4372355013 creator A5088163682 @default.
- W4372355013 creator A5089517724 @default.
- W4372355013 creator A5091819207 @default.
- W4372355013 date "2023-05-06" @default.
- W4372355013 modified "2023-10-16" @default.
- W4372355013 title "In-vitro antiplatelet effect of melatonin in healthy individuals and patients with type 2 diabetes mellitus" @default.
- W4372355013 cites W1538008426 @default.
- W4372355013 cites W1975068275 @default.
- W4372355013 cites W1982974848 @default.
- W4372355013 cites W1994517522 @default.
- W4372355013 cites W1997426843 @default.
- W4372355013 cites W2009175207 @default.
- W4372355013 cites W2019955714 @default.
- W4372355013 cites W2022421613 @default.
- W4372355013 cites W2043774516 @default.
- W4372355013 cites W2043781507 @default.
- W4372355013 cites W2049166597 @default.
- W4372355013 cites W2057957655 @default.
- W4372355013 cites W2059971149 @default.
- W4372355013 cites W2088036396 @default.
- W4372355013 cites W2088800179 @default.
- W4372355013 cites W2112022029 @default.
- W4372355013 cites W2119321943 @default.
- W4372355013 cites W2127125241 @default.
- W4372355013 cites W2127639428 @default.
- W4372355013 cites W2164324917 @default.
- W4372355013 cites W2178493867 @default.
- W4372355013 cites W2182082299 @default.
- W4372355013 cites W2198678228 @default.
- W4372355013 cites W2274836352 @default.
- W4372355013 cites W2294355990 @default.
- W4372355013 cites W2297782609 @default.
- W4372355013 cites W2328529137 @default.
- W4372355013 cites W2341665659 @default.
- W4372355013 cites W2400729428 @default.
- W4372355013 cites W2527039926 @default.
- W4372355013 cites W2559615636 @default.
- W4372355013 cites W2566927390 @default.
- W4372355013 cites W2731875026 @default.
- W4372355013 cites W2741393094 @default.
- W4372355013 cites W2741577291 @default.
- W4372355013 cites W2763698944 @default.
- W4372355013 cites W2779018291 @default.
- W4372355013 cites W2883371150 @default.
- W4372355013 cites W2888543854 @default.
- W4372355013 cites W2963446855 @default.
- W4372355013 cites W2981704471 @default.
- W4372355013 cites W3019658318 @default.
- W4372355013 cites W3033644036 @default.
- W4372355013 cites W3041878974 @default.
- W4372355013 cites W3110220601 @default.
- W4372355013 cites W4206430225 @default.
- W4372355013 cites W4230914943 @default.
- W4372355013 cites W4248052546 @default.
- W4372355013 cites W4303473062 @default.
- W4372355013 doi "https://doi.org/10.1007/s40618-023-02102-7" @default.
- W4372355013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37148530" @default.
- W4372355013 hasPublicationYear "2023" @default.
- W4372355013 type Work @default.
- W4372355013 citedByCount "0" @default.
- W4372355013 crossrefType "journal-article" @default.
- W4372355013 hasAuthorship W4372355013A5007650341 @default.
- W4372355013 hasAuthorship W4372355013A5012697290 @default.
- W4372355013 hasAuthorship W4372355013A5016305753 @default.
- W4372355013 hasAuthorship W4372355013A5025251556 @default.
- W4372355013 hasAuthorship W4372355013A5031384737 @default.
- W4372355013 hasAuthorship W4372355013A5031730926 @default.
- W4372355013 hasAuthorship W4372355013A5044687162 @default.
- W4372355013 hasAuthorship W4372355013A5050312824 @default.
- W4372355013 hasAuthorship W4372355013A5059819092 @default.
- W4372355013 hasAuthorship W4372355013A5062276099 @default.
- W4372355013 hasAuthorship W4372355013A5075985473 @default.
- W4372355013 hasAuthorship W4372355013A5086881397 @default.
- W4372355013 hasAuthorship W4372355013A5088163682 @default.
- W4372355013 hasAuthorship W4372355013A5089517724 @default.
- W4372355013 hasAuthorship W4372355013A5091819207 @default.
- W4372355013 hasBestOaLocation W43723550131 @default.
- W4372355013 hasConcept C121446783 @default.
- W4372355013 hasConcept C126322002 @default.
- W4372355013 hasConcept C134018914 @default.
- W4372355013 hasConcept C19720800 @default.
- W4372355013 hasConcept C2777399203 @default.
- W4372355013 hasConcept C2778182776 @default.
- W4372355013 hasConcept C2910068830 @default.
- W4372355013 hasConcept C2993802102 @default.
- W4372355013 hasConcept C3018697912 @default.