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- W4372404341 abstract "Abstract Experimental rat models of stroke and hemorrhage are important tools to investigate cerebrovascular disease pathophysi- ology mechanisms, yet how significant patterns of functional impairment induced in various models of stroke are related to changes in connectivity at the level of neuronal populations and mesoscopic parcellations of rat brains remain unresolved. To address this gap in knowledge, we employed two middle cerebral artery occlusion models and one intracerebral hemorrhage model with variant extent and location of neuronal dysfunction. Motor and spatial memory function was assessed and the level of hippocampal activation via Fos immunohistochemistry. Contribution of connectivity change to functional impairment was analyzed for connection similarities, graph distances and spatial distances as well as the importance of regions in terms of network architecture based on the neuroVIISAS rat connectome. We found that functional impairment correlated with not only the extent but also the locations of the injury among the models. In addition, via coactivation analysis in dynamic rat brain models, we found that lesioned regions led to stronger coactivations with motor function and spatial learning regions than with other unaffected regions of the connectome. Dynamic modeling with the weighted bilateral connectome detected changes in signal propagation in the remote hippocampus in all 3 stroke types, predicting the extent of hippocampal hypoactivation and impairment in spatial learning and memory function. Our study provides a comprehensive analytical framework in predictive identification of remote regions not directly altered by stroke events and their functional implication." @default.
- W4372404341 created "2023-05-07" @default.
- W4372404341 creator A5008660322 @default.
- W4372404341 creator A5011241874 @default.
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- W4372404341 creator A5016881389 @default.
- W4372404341 creator A5059425358 @default.
- W4372404341 creator A5078808033 @default.
- W4372404341 date "2023-05-05" @default.
- W4372404341 modified "2023-10-03" @default.
- W4372404341 title "Connectome-based prediction of functional impairment in experimental stroke models" @default.
- W4372404341 cites W1502421007 @default.
- W4372404341 cites W1510554078 @default.
- W4372404341 cites W1526173134 @default.
- W4372404341 cites W1539683305 @default.
- W4372404341 cites W1562561653 @default.
- W4372404341 cites W1572757737 @default.
- W4372404341 cites W1603824339 @default.
- W4372404341 cites W1628688887 @default.
- W4372404341 cites W1728222780 @default.
- W4372404341 cites W1750943560 @default.
- W4372404341 cites W1865645241 @default.
- W4372404341 cites W1926351161 @default.
- W4372404341 cites W1965069238 @default.
- W4372404341 cites W1965202959 @default.
- W4372404341 cites W1965688590 @default.
- W4372404341 cites W1968801051 @default.
- W4372404341 cites W1968905959 @default.
- W4372404341 cites W1969116800 @default.
- W4372404341 cites W1971421925 @default.
- W4372404341 cites W1973761728 @default.
- W4372404341 cites W1974458913 @default.
- W4372404341 cites W1974615796 @default.
- W4372404341 cites W1976922231 @default.
- W4372404341 cites W1977744945 @default.
- W4372404341 cites W1981691199 @default.
- W4372404341 cites W1981944303 @default.
- W4372404341 cites W1984089160 @default.
- W4372404341 cites W1985816949 @default.
- W4372404341 cites W1986280777 @default.
- W4372404341 cites W1988334437 @default.
- W4372404341 cites W1991494792 @default.
- W4372404341 cites W1994064011 @default.
- W4372404341 cites W1995874468 @default.
- W4372404341 cites W1996688701 @default.
- W4372404341 cites W1997680969 @default.
- W4372404341 cites W1997855264 @default.
- W4372404341 cites W2000608996 @default.
- W4372404341 cites W2001306967 @default.
- W4372404341 cites W2007106860 @default.
- W4372404341 cites W2010784923 @default.
- W4372404341 cites W2011073327 @default.
- W4372404341 cites W2011431046 @default.
- W4372404341 cites W2011504521 @default.
- W4372404341 cites W2018367689 @default.
- W4372404341 cites W2024758252 @default.
- W4372404341 cites W2024892001 @default.
- W4372404341 cites W2028419487 @default.
- W4372404341 cites W2028852807 @default.
- W4372404341 cites W2029406775 @default.
- W4372404341 cites W2029942338 @default.
- W4372404341 cites W2030034288 @default.
- W4372404341 cites W2030679638 @default.
- W4372404341 cites W2032847834 @default.
- W4372404341 cites W2033366046 @default.
- W4372404341 cites W2033743599 @default.
- W4372404341 cites W2034389479 @default.
- W4372404341 cites W2039143226 @default.
- W4372404341 cites W2040756306 @default.
- W4372404341 cites W2040847131 @default.
- W4372404341 cites W2041226345 @default.
- W4372404341 cites W2042796201 @default.
- W4372404341 cites W2043846563 @default.
- W4372404341 cites W2051134452 @default.
- W4372404341 cites W2052895917 @default.
- W4372404341 cites W2055007123 @default.
- W4372404341 cites W2055452349 @default.
- W4372404341 cites W2060496651 @default.
- W4372404341 cites W2061191702 @default.
- W4372404341 cites W2063251739 @default.
- W4372404341 cites W2082069436 @default.
- W4372404341 cites W2084649299 @default.
- W4372404341 cites W2084811175 @default.
- W4372404341 cites W2085107183 @default.
- W4372404341 cites W2086167759 @default.
- W4372404341 cites W2087716957 @default.
- W4372404341 cites W2087861759 @default.
- W4372404341 cites W2088905367 @default.
- W4372404341 cites W2094714876 @default.
- W4372404341 cites W2096714570 @default.
- W4372404341 cites W2101353854 @default.
- W4372404341 cites W2105119061 @default.
- W4372404341 cites W2105892294 @default.
- W4372404341 cites W2108030081 @default.
- W4372404341 cites W2109181987 @default.
- W4372404341 cites W2110675237 @default.
- W4372404341 cites W2111724994 @default.
- W4372404341 cites W2113481800 @default.
- W4372404341 cites W2113783170 @default.
- W4372404341 cites W2117893550 @default.