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- W4375151957 endingPage "7141" @default.
- W4375151957 startingPage "7135" @default.
- W4375151957 abstract "Abstract Pt II complexes are commonly used to treat cancer. To reduce their side effects and improve their pharmacological properties, Pt IV complexes are being developed as prodrug candidates that are activated by reduction in cancer cells. Concomitantly, Ru II polypyridine complexes have gained much attention as photosensitizers for use in photodynamic therapy due to their attractive characteristics. In this article, a novel Pt IV –Ru II conjugate, which combines cancer activated chemotherapy with PDT, is presented. Upon entering the cancer cell, the Pt IV centre is reduced to Pt II and the axial ligands including the Ru II complex and phenylbutyrate are released. As each component has its individual targets, the conjugate exerts a multi‐target and multi‐action effect with (photo‐)cytotoxicity values upon irradiation up to 595 nm in the low nanomolar range in various (drug resistant) 2D monolayer cancer cells and 3D multicellular tumour spheroids." @default.
- W4375151957 created "2023-05-09" @default.
- W4375151957 creator A5021949552 @default.
- W4375151957 creator A5059114538 @default.
- W4375151957 creator A5061166858 @default.
- W4375151957 creator A5068077465 @default.
- W4375151957 creator A5073113943 @default.
- W4375151957 date "2020-03-11" @default.
- W4375151957 modified "2023-10-14" @default.
- W4375151957 title "A Multi‐action and Multi‐target Ru <sup>II</sup> –Pt <sup>IV</sup> Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers" @default.
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- W4375151957 doi "https://doi.org/10.1002/ange.201916400" @default.
- W4375151957 hasPublicationYear "2020" @default.
- W4375151957 type Work @default.