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• W4375844576 abstract "Introduction: The underlying molecular mechanisms responsible for omega-3 PUFAs’ biological effects are mediated by the production of pro-resolving mediators, which have been proposed to modulate and likely resolve inflammatory responses. The anti-inflammatory action of dietary omega-3-polyunsaturated fatty acid supplementation in animal models has been studied using membrane stabilization and vascular permeability methods. This study is, therefore, focused on the long-term therapeutic safety and efficacy of fish oil supplements as a safer alternative to traditional NSAIDs. Also, whether these methods serve as mechanisms of antiinflammation has been confirmed further. Method: Animals were distributed in six groups of five each (n = 5). Group 1 was administered 300mg/ml omega-3 fatty acids (n-3 FA) containing 180mg/ml EPA and 120mg/ml DHA; group 2 received 600mg/ml n-3 FA containing 360mg/ml EPA and 240mg/ml DHA; group 3 received 900mg/ml n-3 FA containing 540mg/ml EPA and 360mg/ml DHA; group 4 was administered 300mg/ml of the fish oil along with 20mg/ml celecoxib; group 5 was given 20mg/ml celecoxib that represented the positive control, and group 6 was administered 2 ml phosphate buffer saline alone, which served as the vehicle control group. Membrane stabilization of the rat’s red blood cells and aceticacid-induced vascular permeability were assayed. The percentage inhibition was determined. The analysis was performed using GraphPad InStat version 5 software and subjected to the Bonferroni test for the separation of means. Result: The results of membrane stabilization assays exhibited 30.59%, 27.70%, 49.63%, 55.41%, 57.28%, and 13.13% inhibitions, and vascular permeability inhibitions were found to be 80.05%, 53.27%, 74.31%, 86.33%, and 90.43%, respectively. The results provide scientific evidence for the use of dietary omega-3-polyunsaturated fatty acid as a food supplement capable of resolving inflammatory conditions without side effects produced by traditional NSAIDs. Conclusion: The restoration of altered membrane permeability and vasculature is a testament to the efficacy of omega-3 as an anti-inflammatory agent and indeed shows these methods as anti-inflammatory mechanisms. The bioactive components in omega-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in fish oil are capable of interrupting the prostaglandin metabolic pathway by competing with arachidonic acids for the COX active site, thereby inhibiting their synthesis." @default.
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• W4375844576 date "2023-05-05" @default.
• W4375844576 modified "2023-09-27" @default.
• W4375844576 title "Membrane Stabilization and Vascular Permeability as Mechanisms for the Evaluation of Anti-inflammatory Action of Omega-3-poly Unsaturated Fatty Acid Oil Extract" @default.
• W4375844576 doi "https://doi.org/10.2174/1573401319666230505155957" @default.
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