FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4375846893> ?p ?o ?g. }

• W4375846893 endingPage "106840" @default.
• W4375846893 startingPage "106840" @default.
• W4375846893 abstract "The ability of ethambutol (EMB) to suppress bacterial resistance has been demonstrated in a time-dependent manner. Through the development of a population pharmacokinetics (PK) model, this study aimed to suggest the PK/pharmacodynamics (PD) target and identify the significant covariates that influence interindividual variability (IIV) in the PK of EMB. In total, 837 patients from 20 medical centres across Korea were enrolled in this study. The non-linear mixed-effect method was used to establish and validate the population PK model. A two-compartment model with transit compartment absorption was sufficient to describe the PK of EMB. Body weight and renal function were identified as significant covariates that affect IIV of the apparent clearance (CL/F) of EMB. Patients with moderate renal function showed 35% and 55% lower CL/F (CL/F 89.9 L/h) compared with those with mild and normal renal function, respectively. All the renal function groups with simulated doses ranging from 800 to 1200 mg achieved area under the curve over minimum inhibitory concentration (MIC) >119, and maintained T>MIC for >23 h for MIC of 0.5 µg/mL. Based on our simulation result, it is suggested that doses of 800, 1000, and 1200 mg should obtain the T>MIC target of 4, 6, and 8 h, respectively. This model was validated internally and externally. This study provides insight into the PK/PD indexes of EMB for three different renal function groups and T>MIC targets for different doses. The results could be used to provide optimal-dose suggestions for EMB." @default.
• W4375846893 created "2023-05-10" @default.
• W4375846893 creator A5005127243 @default.
• W4375846893 creator A5018848859 @default.
• W4375846893 creator A5020851247 @default.
• W4375846893 creator A5026101027 @default.
• W4375846893 creator A5027330061 @default.
• W4375846893 creator A5034917040 @default.
• W4375846893 creator A5035112064 @default.
• W4375846893 creator A5036862812 @default.
• W4375846893 creator A5044232660 @default.
• W4375846893 creator A5057467146 @default.
• W4375846893 creator A5059600515 @default.
• W4375846893 creator A5068280842 @default.
• W4375846893 creator A5082152803 @default.
• W4375846893 creator A5085136192 @default.
• W4375846893 creator A5091482988 @default.
• W4375846893 date "2023-08-01" @default.
• W4375846893 modified "2023-09-30" @default.
• W4375846893 title "Recommendation of pharmacokinetics/pharmacodynamics target of ethambutol to suppress tuberculosis resistance: A population pharmacokinetics study on a large prospective cohort" @default.
• W4375846893 cites W100687419 @default.
• W4375846893 cites W1484456826 @default.
• W4375846893 cites W1619100289 @default.
• W4375846893 cites W1834506558 @default.
• W4375846893 cites W2001488455 @default.
• W4375846893 cites W2003143162 @default.
• W4375846893 cites W2016354947 @default.
• W4375846893 cites W2027951201 @default.
• W4375846893 cites W2029728996 @default.
• W4375846893 cites W2042553471 @default.
• W4375846893 cites W2045797114 @default.
• W4375846893 cites W2066464642 @default.
• W4375846893 cites W2068357196 @default.
• W4375846893 cites W2102855070 @default.
• W4375846893 cites W2117897510 @default.
• W4375846893 cites W2142944749 @default.
• W4375846893 cites W2150589034 @default.
• W4375846893 cites W2155881009 @default.
• W4375846893 cites W2157279849 @default.
• W4375846893 cites W2164438043 @default.
• W4375846893 cites W2172137232 @default.
• W4375846893 cites W2183940924 @default.
• W4375846893 cites W2246740579 @default.
• W4375846893 cites W2267486699 @default.
• W4375846893 cites W2295478175 @default.
• W4375846893 cites W2299256917 @default.
• W4375846893 cites W2516938750 @default.
• W4375846893 cites W2522905475 @default.
• W4375846893 cites W2594017340 @default.
• W4375846893 cites W2669644938 @default.
• W4375846893 cites W2809562126 @default.
• W4375846893 cites W2984762609 @default.
• W4375846893 cites W2996600019 @default.
• W4375846893 cites W3135702228 @default.
• W4375846893 cites W4200364970 @default.
• W4375846893 cites W4211025575 @default.
• W4375846893 cites W4225096580 @default.
• W4375846893 cites W4226277136 @default.
• W4375846893 cites W4229019904 @default.
• W4375846893 cites W4307231853 @default.
• W4375846893 doi "https://doi.org/10.1016/j.ijantimicag.2023.106840" @default.
• W4375846893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37160240" @default.
• W4375846893 hasPublicationYear "2023" @default.
• W4375846893 type Work @default.
• W4375846893 citedByCount "0" @default.
• W4375846893 crossrefType "journal-article" @default.
• W4375846893 hasAuthorship W4375846893A5005127243 @default.
• W4375846893 hasAuthorship W4375846893A5018848859 @default.
• W4375846893 hasAuthorship W4375846893A5020851247 @default.
• W4375846893 hasAuthorship W4375846893A5026101027 @default.
• W4375846893 hasAuthorship W4375846893A5027330061 @default.
• W4375846893 hasAuthorship W4375846893A5034917040 @default.
• W4375846893 hasAuthorship W4375846893A5035112064 @default.
• W4375846893 hasAuthorship W4375846893A5036862812 @default.
• W4375846893 hasAuthorship W4375846893A5044232660 @default.
• W4375846893 hasAuthorship W4375846893A5057467146 @default.
• W4375846893 hasAuthorship W4375846893A5059600515 @default.
• W4375846893 hasAuthorship W4375846893A5068280842 @default.
• W4375846893 hasAuthorship W4375846893A5082152803 @default.
• W4375846893 hasAuthorship W4375846893A5085136192 @default.
• W4375846893 hasAuthorship W4375846893A5091482988 @default.
• W4375846893 hasBestOaLocation W43758468931 @default.
• W4375846893 hasConcept C111113717 @default.
• W4375846893 hasConcept C112705442 @default.
• W4375846893 hasConcept C126322002 @default.
• W4375846893 hasConcept C126894567 @default.
• W4375846893 hasConcept C142724271 @default.
• W4375846893 hasConcept C159641895 @default.
• W4375846893 hasConcept C176947019 @default.
• W4375846893 hasConcept C185592680 @default.
• W4375846893 hasConcept C2776228421 @default.
• W4375846893 hasConcept C2778607973 @default.
• W4375846893 hasConcept C2781069245 @default.
• W4375846893 hasConcept C2908647359 @default.
• W4375846893 hasConcept C501593827 @default.
• W4375846893 hasConcept C55493867 @default.
• W4375846893 hasConcept C71924100 @default.
• W4375846893 hasConcept C76318530 @default.

• next