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• W4375851172 endingPage "109823" @default.
• W4375851172 startingPage "109823" @default.
• W4375851172 abstract "Background Patients resuscitated from cardiac arrest have variable severity of primary hypoxic ischemic brain injury (HIBI). Signatures of primary HIBI on brain imaging and electroencephalography (EEG) include diffuse cerebral edema and burst suppression with identical bursts (BSIB). We hypothesize distinct phenotypes of primary HIBI are associated with increasing cardiopulmonary resuscitation (CPR) duration. Methods We identified from our prospective registry of both in-and out-of-hospital CA patients treated between January 2010 to January 2020 for this cohort study. We abstracted CPR duration, neurological examination, initial brain computed tomography gray to white ratio (GWR), and initial EEG pattern. We considered four phenotypes on presentation: awake; comatose with neither BSIB nor cerebral edema (non-malignant coma); BSIB; and cerebral edema (GWR ≤ 1.20). BSIB and cerebral edema were considered as non-mutually exclusive outcomes. We generated predicted probabilities of brain injury phenotype using localized regression. Results We included 2,440 patients, of whom 545 (23%) were awake, 1,065 (44%) had non-malignant coma, 548 (23%) had BSIB and 438 (18%) had cerebral edema. Only 92 (4%) had both BSIB and edema. Median CPR duration was 16 [IQR 8–28] minutes. Median CPR duration increased in a stepwise manner across groups: awake 6 [3–13] minutes; non-malignant coma 15 [8–25] minutes; BSIB 21 [13–31] minutes; cerebral edema 32 [22–46] minutes. Predicted probability of phenotype changes over time. Conclusions Brain injury phenotype is related to CPR duration, which is a surrogate for severity of HIBI. The sequence of most likely primary HIBI phenotype with progressively longer CPR duration is awake, coma without BSIB or edema, BSIB, and finally cerebral edema." @default.
• W4375851172 created "2023-05-10" @default.
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• W4375851172 date "2023-07-01" @default.
• W4375851172 modified "2023-09-26" @default.
• W4375851172 title "Duration of cardiopulmonary resuscitation and phenotype of post-cardiac arrest brain injury" @default.
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• W4375851172 doi "https://doi.org/10.1016/j.resuscitation.2023.109823" @default.
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