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- W4375851569 abstract "Ischemic stroke (IS) is characterized by high incidence, high recurrence, and high mortality and places a heavy burden on society and families. The pathological mechanisms of IS are complex, among which secondary neurological impairment mediated by neuroinflammation is considered to be the main factor in cerebral ischemic injury. At present, there is still a lack of specific therapies to treat neuroinflammation. The tumor suppressor protein p53 has long been regarded as a key substance in the regulation of the cell cycle and apoptosis in the past. Recently, studies have found that p53 also plays an important role in neuroinflammatory diseases, such as IS. Therefore, p53 may be a crucial target for the regulation of the neuroinflammatory response. Here, we provide a comprehensive review of the potential of targeting p53 in the treatment of neuroinflammation after IS. We describe the function of p53, the major immune cells involved in neuroinflammation, and the role of p53 in inflammatory responses mediated by these cells. Finally, we summarize the therapeutic strategies of targeting p53 in regulating the neuroinflammatory response after IS to provide new directions and ideas for the treatment of ischemic brain injury." @default.
- W4375851569 created "2023-05-10" @default.
- W4375851569 creator A5016217233 @default.
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- W4375851569 creator A5022216633 @default.
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- W4375851569 creator A5035277839 @default.
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- W4375851569 creator A5050295166 @default.
- W4375851569 creator A5069998507 @default.
- W4375851569 creator A5088224261 @default.
- W4375851569 date "2023-05-08" @default.
- W4375851569 modified "2023-10-16" @default.
- W4375851569 title "Targeting p53 for neuroinflammation: New therapeutic strategies in ischemic stroke" @default.
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