Matches in SemOpenAlex for { <https://semopenalex.org/work/W4375851625> ?p ?o ?g. }
- W4375851625 endingPage "105611" @default.
- W4375851625 startingPage "105611" @default.
- W4375851625 abstract "The aims were to characterize the content of elements and polycyclic aromatic hydrocarbons (PAHs) in size-separated particulate matter (PM) sampled in a road tunnel, estimate the contribution of PAHs to the toxic potential, and measure the pro-inflammatory potential of PM samples and extracts with increasing polarity. Several elements/metals previously associated with cytokine responses were found. Based on PAHs levels and published PAHs potency, the calculated mutagenic and carcinogenic activities of size-separated samples were somewhat lower for coarse than fine and ultrafine PM. The AhR-activity of the corresponding PM extracts measured in an AhR-luciferase reporter model (human hepatocytes) were more similar. The highest AhR-activity was found in the neutral (parent and alkylated PAHs) and polar (oxy-PAHs) fractions, while the semi-polar fractions (mono-nitrated-PAHs) had only weak activity. The neutral and polar aromatic fractions from coarse and fine PM were also found to induce higher pro-inflammatory responses and CYP1A1 expression in human bronchial epithelial cells (HBEC3-KT) than the semi-polar fractions. Fine PM induced higher pro-inflammatory responses than coarse PM. AhR-inhibition reduced cytokine responses induced by parent PM and extracts of both size fractions. Contributors to the toxic potentials include PAHs and oxy-PAHs, but substantial contributions from other organic compounds and/or metals are likely." @default.
- W4375851625 created "2023-05-10" @default.
- W4375851625 creator A5006674415 @default.
- W4375851625 creator A5010012417 @default.
- W4375851625 creator A5014466291 @default.
- W4375851625 creator A5032352078 @default.
- W4375851625 creator A5037123250 @default.
- W4375851625 creator A5037253164 @default.
- W4375851625 creator A5042219680 @default.
- W4375851625 creator A5049223044 @default.
- W4375851625 creator A5052929958 @default.
- W4375851625 creator A5053804939 @default.
- W4375851625 creator A5058671863 @default.
- W4375851625 creator A5064376052 @default.
- W4375851625 creator A5092336923 @default.
- W4375851625 date "2023-08-01" @default.
- W4375851625 modified "2023-10-18" @default.
- W4375851625 title "Characterization of elements, PAHs, AhR-activity and pro-inflammatory responses of road tunnel-derived particulate matter in human hepatocyte-like and bronchial epithelial cells" @default.
- W4375851625 cites W1540016031 @default.
- W4375851625 cites W1599437589 @default.
- W4375851625 cites W1873104990 @default.
- W4375851625 cites W1963833708 @default.
- W4375851625 cites W1969929487 @default.
- W4375851625 cites W1977673645 @default.
- W4375851625 cites W1980816609 @default.
- W4375851625 cites W1983501807 @default.
- W4375851625 cites W1984009390 @default.
- W4375851625 cites W1993619636 @default.
- W4375851625 cites W2000006166 @default.
- W4375851625 cites W2002389528 @default.
- W4375851625 cites W2004522121 @default.
- W4375851625 cites W2005904261 @default.
- W4375851625 cites W2007434310 @default.
- W4375851625 cites W2007980204 @default.
- W4375851625 cites W2013331721 @default.
- W4375851625 cites W2013446255 @default.
- W4375851625 cites W2014674512 @default.
- W4375851625 cites W2032960075 @default.
- W4375851625 cites W2038778551 @default.
- W4375851625 cites W2049084155 @default.
- W4375851625 cites W2053103062 @default.
- W4375851625 cites W2059228550 @default.
- W4375851625 cites W2061778686 @default.
- W4375851625 cites W2072960495 @default.
- W4375851625 cites W2086659744 @default.
- W4375851625 cites W2114850442 @default.
- W4375851625 cites W2122939933 @default.
- W4375851625 cites W2137615900 @default.
- W4375851625 cites W2143143891 @default.
- W4375851625 cites W2151084151 @default.
- W4375851625 cites W2156567043 @default.
- W4375851625 cites W2162026377 @default.
- W4375851625 cites W2162660887 @default.
- W4375851625 cites W2289759475 @default.
- W4375851625 cites W2412214305 @default.
- W4375851625 cites W2421710065 @default.
- W4375851625 cites W2462489590 @default.
- W4375851625 cites W2512579542 @default.
- W4375851625 cites W2527670917 @default.
- W4375851625 cites W2561051095 @default.
- W4375851625 cites W2783528693 @default.
- W4375851625 cites W2793063480 @default.
- W4375851625 cites W2893863934 @default.
- W4375851625 cites W2900445897 @default.
- W4375851625 cites W2906492750 @default.
- W4375851625 cites W2947725468 @default.
- W4375851625 cites W2973736433 @default.
- W4375851625 cites W3101241338 @default.
- W4375851625 cites W3102516624 @default.
- W4375851625 cites W3129247812 @default.
- W4375851625 cites W3165984234 @default.
- W4375851625 cites W3196697920 @default.
- W4375851625 cites W4205887866 @default.
- W4375851625 cites W4212801629 @default.
- W4375851625 cites W4221107464 @default.
- W4375851625 cites W4281480472 @default.
- W4375851625 cites W4283796422 @default.
- W4375851625 cites W4301595870 @default.
- W4375851625 doi "https://doi.org/10.1016/j.tiv.2023.105611" @default.
- W4375851625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37164185" @default.
- W4375851625 hasPublicationYear "2023" @default.
- W4375851625 type Work @default.
- W4375851625 citedByCount "1" @default.
- W4375851625 countsByYear W43758516252023 @default.
- W4375851625 crossrefType "journal-article" @default.
- W4375851625 hasAuthorship W4375851625A5006674415 @default.
- W4375851625 hasAuthorship W4375851625A5010012417 @default.
- W4375851625 hasAuthorship W4375851625A5014466291 @default.
- W4375851625 hasAuthorship W4375851625A5032352078 @default.
- W4375851625 hasAuthorship W4375851625A5037123250 @default.
- W4375851625 hasAuthorship W4375851625A5037253164 @default.
- W4375851625 hasAuthorship W4375851625A5042219680 @default.
- W4375851625 hasAuthorship W4375851625A5049223044 @default.
- W4375851625 hasAuthorship W4375851625A5052929958 @default.
- W4375851625 hasAuthorship W4375851625A5053804939 @default.
- W4375851625 hasAuthorship W4375851625A5058671863 @default.
- W4375851625 hasAuthorship W4375851625A5064376052 @default.
- W4375851625 hasAuthorship W4375851625A5092336923 @default.