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- W4375856097 abstract "Purpose To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD). Methods Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography. The Movement Disorder Society-Unified Parkinsońs Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), and Montreal Cognitive Assessment (MoCA) were used to assess motor, non-motor, and cognition. Results In PD, total αSyn levels were increased compared to control subjects [1.76pg/mL (IQR 1.74–1.80) vs 1.73pg/mL (IQR 1.70–1.77), p < 0.004]. The nerve fiber layer, ganglion cell layer, internal plexiform layer, inner nuclear layer, and outer nuclear layer were thinner in PD in comparison with controls (p < 0.05). The outer plexiform layer and retinal pigment epithelium were thicker in PD (p < 0.05). The total αSyn levels positively correlated with the central volume of the inner nuclear layer (r = 0.357, p = 0.009). Conclusion Total αSyn reflex tear levels were increased in subjects with PD compared to controls. PD patients showed significant thinning of the inner retinal layers and thickening of outer retinal layers in comparison with controls. Total αSyn levels positively correlate with the central volume of the inner nuclear layer in PD. The combination of these biomarkers might have a possible role as a diagnostic tool in PD subjects." @default.
- W4375856097 created "2023-05-10" @default.
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- W4375856097 date "2023-05-07" @default.
- W4375856097 modified "2023-10-09" @default.
- W4375856097 title "Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?" @default.
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- W4375856097 doi "https://doi.org/10.1177/11206721231173725" @default.
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