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• W4375858711 endingPage "104551" @default.
• W4375858711 startingPage "104551" @default.
• W4375858711 abstract "Multidrug-resistant (MDR) pathogens are emerging as a major health and safety concern worldwide. Nanomaterials and phyto-compounds are become novel antibacterial agents to target MDR pathogens. To increase the efficacy of phyto-compound in the treatment of MDR bacteria, the present work aimed to develop and characterize the paeoniflorin (Pae) loaded silica oxide nanoparticles (Pae-SiO2 NPs). The loading of the Pae on SiO2 NPs and the crystallinity of Pae-SiO2 NPs were determined by FTIR and XRD analysis. The Pae-SiO2 NPs exhibited an average hydrodynamic size of 226 ± 7.79 d. nm and a zeta potential of 28.4 ± 4.59 mV. Furthermore, Pae-SiO2 NPs showed a strong antibacterial effect on Staphylococcus aureus and Bacillus cereus. In addition, Pae-SiO2 NPs showed lowest cytotoxicity and hemolysis in human embryonic kidney 293 cells (HEK 293) and red blood cells (RBC), respectively. Overall, the present results revealed that the Pae-SiO2 NPs exhibited a higher antibacterial activity with lesser toxicity to HEK 293 cells and RBC." @default.
• W4375858711 created "2023-05-10" @default.
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• W4375858711 date "2023-06-01" @default.
• W4375858711 modified "2023-09-27" @default.
• W4375858711 title "Characterization, cytotoxicity, and antibacterial activity of paeoniflorin-loaded mesoporous silica oxide nanoparticles" @default.
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• W4375858711 doi "https://doi.org/10.1016/j.jddst.2023.104551" @default.
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