FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4375860261> ?p ?o ?g. }

• W4375860261 endingPage "8477" @default.
• W4375860261 startingPage "8469" @default.
• W4375860261 abstract "A higher-order structure (HOS) is critical to a biopharmaceutical drug as the three-dimensional structure governs its function. Even the partial perturbation in the HOS of the drug can alter the biological efficiency and efficacy. Due to current limitations in analytical technologies, it is imperative to develop a protocol to characterize the HOS of biopharmaceuticals in the native formulated state. This becomes even more challenging for the suspension formulations where solution and solid phases co-exist. Here, we have used a combinatorial approach using liquid (1D 1H) and solid-state (13C CP MAS) NMR methodology to demonstrate the HOS in the biphasic microcrystalline suspension drug in its formulated state. The data were further assessed by principal component analysis and Mahalanobis distance (DM) calculation for quantitative assessment. This approach is sufficient to provide information regarding the protein HOS and the local dynamics of the molecule when combined with orthogonal techniques such as X-ray scattering. Our method can be an elegant tool to investigate batch-to-batch variation in the process of manufacture and storage as well as a biosimilarity comparison study for biphasic/microcrystalline suspension." @default.
• W4375860261 created "2023-05-10" @default.
• W4375860261 creator A5016592808 @default.
• W4375860261 creator A5044904934 @default.
• W4375860261 creator A5058271102 @default.
• W4375860261 creator A5092338103 @default.
• W4375860261 date "2023-05-08" @default.
• W4375860261 modified "2023-10-09" @default.
• W4375860261 title "Combined Liquid-State and Solid-State Nuclear Magnetic Resonance at Natural Abundance for Comparative Higher Order Structure Assessment in the Formulated-State of Biphasic Biopharmaceutics" @default.
• W4375860261 cites W1497394985 @default.
• W4375860261 cites W1968012146 @default.
• W4375860261 cites W1971014721 @default.
• W4375860261 cites W1978286380 @default.
• W4375860261 cites W2007450029 @default.
• W4375860261 cites W2011684044 @default.
• W4375860261 cites W2012583869 @default.
• W4375860261 cites W2012860987 @default.
• W4375860261 cites W2016815859 @default.
• W4375860261 cites W2026558129 @default.
• W4375860261 cites W2026727321 @default.
• W4375860261 cites W2037651584 @default.
• W4375860261 cites W2042436886 @default.
• W4375860261 cites W2048353956 @default.
• W4375860261 cites W2049681010 @default.
• W4375860261 cites W2049927341 @default.
• W4375860261 cites W2058469509 @default.
• W4375860261 cites W2062728957 @default.
• W4375860261 cites W2076100371 @default.
• W4375860261 cites W2080659559 @default.
• W4375860261 cites W2082142091 @default.
• W4375860261 cites W2082570714 @default.
• W4375860261 cites W2087066457 @default.
• W4375860261 cites W2090108443 @default.
• W4375860261 cites W2107746113 @default.
• W4375860261 cites W2109394678 @default.
• W4375860261 cites W2110938950 @default.
• W4375860261 cites W2132246525 @default.
• W4375860261 cites W2151188170 @default.
• W4375860261 cites W2162474792 @default.
• W4375860261 cites W231657163 @default.
• W4375860261 cites W2475096707 @default.
• W4375860261 cites W2527913902 @default.
• W4375860261 cites W2557247739 @default.
• W4375860261 cites W2563087913 @default.
• W4375860261 cites W2583066618 @default.
• W4375860261 cites W2612871049 @default.
• W4375860261 cites W2619233723 @default.
• W4375860261 cites W2949551892 @default.
• W4375860261 cites W2999807902 @default.
• W4375860261 cites W3008730383 @default.
• W4375860261 cites W3042332451 @default.
• W4375860261 cites W3093676761 @default.
• W4375860261 cites W3094051077 @default.
• W4375860261 cites W3112500811 @default.
• W4375860261 cites W4210752148 @default.
• W4375860261 cites W4229943688 @default.
• W4375860261 cites W4237638355 @default.
• W4375860261 doi "https://doi.org/10.1021/acs.analchem.2c05485" @default.
• W4375860261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37154614" @default.
• W4375860261 hasPublicationYear "2023" @default.
• W4375860261 type Work @default.
• W4375860261 citedByCount "0" @default.
• W4375860261 crossrefType "journal-article" @default.
• W4375860261 hasAuthorship W4375860261A5016592808 @default.
• W4375860261 hasAuthorship W4375860261A5044904934 @default.
• W4375860261 hasAuthorship W4375860261A5058271102 @default.
• W4375860261 hasAuthorship W4375860261A5092338103 @default.
• W4375860261 hasConcept C121332964 @default.
• W4375860261 hasConcept C121864883 @default.
• W4375860261 hasConcept C153202636 @default.
• W4375860261 hasConcept C154945302 @default.
• W4375860261 hasConcept C185592680 @default.
• W4375860261 hasConcept C186060115 @default.
• W4375860261 hasConcept C201370411 @default.
• W4375860261 hasConcept C27438332 @default.
• W4375860261 hasConcept C2781047461 @default.
• W4375860261 hasConcept C41008148 @default.
• W4375860261 hasConcept C46141821 @default.
• W4375860261 hasConcept C54355233 @default.
• W4375860261 hasConcept C8010536 @default.
• W4375860261 hasConcept C86803240 @default.
• W4375860261 hasConceptScore W4375860261C121332964 @default.
• W4375860261 hasConceptScore W4375860261C121864883 @default.
• W4375860261 hasConceptScore W4375860261C153202636 @default.
• W4375860261 hasConceptScore W4375860261C154945302 @default.
• W4375860261 hasConceptScore W4375860261C185592680 @default.
• W4375860261 hasConceptScore W4375860261C186060115 @default.
• W4375860261 hasConceptScore W4375860261C201370411 @default.
• W4375860261 hasConceptScore W4375860261C27438332 @default.
• W4375860261 hasConceptScore W4375860261C2781047461 @default.
• W4375860261 hasConceptScore W4375860261C41008148 @default.
• W4375860261 hasConceptScore W4375860261C46141821 @default.
• W4375860261 hasConceptScore W4375860261C54355233 @default.
• W4375860261 hasConceptScore W4375860261C8010536 @default.
• W4375860261 hasConceptScore W4375860261C86803240 @default.
• W4375860261 hasFunder F4320320721 @default.
• W4375860261 hasFunder F4320323448 @default.
• W4375860261 hasIssue "22" @default.

• next