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- W4375865457 abstract "Nuclear-cytoplasmic transport of proteins is essential for normal cellular function but can be disrupted by cancer cells to evade apoptosis and facilitate tumor cell survival and proliferation. As a result, there is growing interest in studying the disruption of nuclear protein transport mechanisms in carcinogenesis as an anti-cancer treatment strategy. One strategy of interest is blockade of the exportin 1 (XPO1), a nuclear export protein, which when dysregulated can suppress key tumor suppressor proteins. This chapter will explore mechanisms of oncogenesis that involve alterations of XPO1 biology and review the key data regarding XPO1 inhibitors in lymphoma. The first-in-class drug targeting this unique process is selinexor (KPT-330), a selective inhibitor of nuclear export (SINE)." @default.
- W4375865457 created "2023-05-10" @default.
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- W4375865457 date "2023-03-15" @default.
- W4375865457 modified "2023-09-26" @default.
- W4375865457 title "Targeting Nuclear Protein Transport with <scp>XPO</scp> Inhibitors in Lymphoma" @default.
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- W4375865457 doi "https://doi.org/10.1002/9781119819950.ch25" @default.
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