Matches in SemOpenAlex for { <https://semopenalex.org/work/W4375946593> ?p ?o ?g. }
- W4375946593 abstract "Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how glucose regulates α-cells has been a topic of debate for decades but it is clear that electrical signals generated by the cells play an important role in glucagon secretory response. Decades of studies have already revealed the key players involved in the generation of these electrical signals and possible mechanisms controlling them to tune glucagon release. This has offered the opportunity to fully understand the enigmatic α-cell physiology. In this review, we describe the current knowledge on cellular electrophysiology and factors regulating excitability, glucose sensing, and glucagon secretion. We also discuss α-cell pathophysiology and the perspective of addressing glucagon secretory defects in diabetes for developing better diabetes treatment, which bears the hope of eliminating hypoglycaemia as a clinical problem in diabetes care." @default.
- W4375946593 created "2023-05-10" @default.
- W4375946593 creator A5005237729 @default.
- W4375946593 creator A5011126534 @default.
- W4375946593 creator A5029095902 @default.
- W4375946593 creator A5046482887 @default.
- W4375946593 creator A5047903101 @default.
- W4375946593 creator A5055720455 @default.
- W4375946593 date "2023-05-09" @default.
- W4375946593 modified "2023-10-01" @default.
- W4375946593 title "α-cell electrophysiology and the regulation of glucagon secretion" @default.
- W4375946593 cites W1490390377 @default.
- W4375946593 cites W1506458831 @default.
- W4375946593 cites W1522924058 @default.
- W4375946593 cites W1552235434 @default.
- W4375946593 cites W1562853684 @default.
- W4375946593 cites W1573621390 @default.
- W4375946593 cites W1589179363 @default.
- W4375946593 cites W1608643486 @default.
- W4375946593 cites W164778302 @default.
- W4375946593 cites W1940160448 @default.
- W4375946593 cites W1965398610 @default.
- W4375946593 cites W1965490690 @default.
- W4375946593 cites W1977392097 @default.
- W4375946593 cites W1977951067 @default.
- W4375946593 cites W1980540026 @default.
- W4375946593 cites W1982407587 @default.
- W4375946593 cites W1988801692 @default.
- W4375946593 cites W1989661079 @default.
- W4375946593 cites W1997511216 @default.
- W4375946593 cites W1999722905 @default.
- W4375946593 cites W2009127988 @default.
- W4375946593 cites W2009667219 @default.
- W4375946593 cites W2010413619 @default.
- W4375946593 cites W2012515461 @default.
- W4375946593 cites W2013974905 @default.
- W4375946593 cites W2015316095 @default.
- W4375946593 cites W2015426350 @default.
- W4375946593 cites W2017509811 @default.
- W4375946593 cites W2019558153 @default.
- W4375946593 cites W2021517048 @default.
- W4375946593 cites W2021920528 @default.
- W4375946593 cites W2021979767 @default.
- W4375946593 cites W2025233052 @default.
- W4375946593 cites W2025993954 @default.
- W4375946593 cites W2026444172 @default.
- W4375946593 cites W2026640914 @default.
- W4375946593 cites W2027929565 @default.
- W4375946593 cites W2029559333 @default.
- W4375946593 cites W2032445998 @default.
- W4375946593 cites W2041346929 @default.
- W4375946593 cites W2041654060 @default.
- W4375946593 cites W2042422091 @default.
- W4375946593 cites W2046064425 @default.
- W4375946593 cites W2047641318 @default.
- W4375946593 cites W2050636523 @default.
- W4375946593 cites W2050841721 @default.
- W4375946593 cites W2054111620 @default.
- W4375946593 cites W2054282126 @default.
- W4375946593 cites W2055769427 @default.
- W4375946593 cites W2058024825 @default.
- W4375946593 cites W2058342085 @default.
- W4375946593 cites W2064908943 @default.
- W4375946593 cites W2081885571 @default.
- W4375946593 cites W2086605260 @default.
- W4375946593 cites W2087707740 @default.
- W4375946593 cites W2088987697 @default.
- W4375946593 cites W2090394751 @default.
- W4375946593 cites W2091676281 @default.
- W4375946593 cites W2095268130 @default.
- W4375946593 cites W2096514865 @default.
- W4375946593 cites W2097461674 @default.
- W4375946593 cites W2097575722 @default.
- W4375946593 cites W2099084891 @default.
- W4375946593 cites W2101814428 @default.
- W4375946593 cites W2102022791 @default.
- W4375946593 cites W2102361775 @default.
- W4375946593 cites W2102877564 @default.
- W4375946593 cites W2103277226 @default.
- W4375946593 cites W2103829969 @default.
- W4375946593 cites W2103920106 @default.
- W4375946593 cites W2104665577 @default.
- W4375946593 cites W2105062255 @default.
- W4375946593 cites W2105379412 @default.
- W4375946593 cites W2105748867 @default.
- W4375946593 cites W2113278846 @default.
- W4375946593 cites W2115337061 @default.
- W4375946593 cites W2115567611 @default.
- W4375946593 cites W2117848154 @default.
- W4375946593 cites W2123411875 @default.
- W4375946593 cites W2125905134 @default.
- W4375946593 cites W2128115766 @default.
- W4375946593 cites W2128147760 @default.
- W4375946593 cites W2131455349 @default.
- W4375946593 cites W2132018095 @default.
- W4375946593 cites W2132251931 @default.
- W4375946593 cites W2137546086 @default.
- W4375946593 cites W2141771305 @default.
- W4375946593 cites W2144173589 @default.
- W4375946593 cites W2144264437 @default.