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- W4375950892 abstract "Abstract Neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are an accelerating global health problem as life expectancy rises worldwide. Despite their significant burden in public health systems to date, the existing treatments only manage the symptoms without slowing down disease progression. Thus, the ongoing neurodegenerative process remains untreated. Moreover, the stronghold of the brain—the blood–brain barrier (BBB)—prevents drug penetrance and dwindles effective treatments. In the last years, nanotechnology‐based drug delivery systems (DDS) have become a promising approach to target and treat these disorders related to the central nervous system (CNS). PLGA based nanoparticles (NPs) were the first employed DDS for effective drug delivery. However, the poor drug loading capacity and localized immunogenicity prompted the scientific community to move to another DDS such as lipid‐based NPs. Despite the lipid NPs' safety and effectiveness, their off‐target accumulation together with the denominated CARPA (complement activation‐related pseudo allergy) reaction has limited their complete clinical translation. Recently, biological NPs naturally secreted by cells, termed as extracellular vesicles (EVs) have emerged as promising more complex biocompatible DDS. In addition, EVs act as dual players in NDs treatment, as a “cell free” therapy themselves, as well as new biological NPs with numerous characteristics that qualify them as promising carriers over synthetic DDS. The present review aims to display advantages, drawbacks, current limitations and future prospective of the previously cited synthetic and biological DDS to enter the brain and treat one of 21st century most challenging diseases, NDs. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease" @default.
- W4375950892 created "2023-05-10" @default.
- W4375950892 creator A5062403122 @default.
- W4375950892 creator A5063429751 @default.
- W4375950892 creator A5071512795 @default.
- W4375950892 creator A5089899406 @default.
- W4375950892 date "2023-05-08" @default.
- W4375950892 modified "2023-09-26" @default.
- W4375950892 title "Targeting the central nervous system: From synthetic nanoparticles to extracellular vesicles—Focus on Alzheimer's and Parkinson's disease" @default.
- W4375950892 cites W1626583747 @default.
- W4375950892 cites W1721689174 @default.
- W4375950892 cites W1734250133 @default.
- W4375950892 cites W1867774233 @default.
- W4375950892 cites W1972856288 @default.
- W4375950892 cites W1976782163 @default.
- W4375950892 cites W1976799053 @default.
- W4375950892 cites W1980328470 @default.
- W4375950892 cites W1982904297 @default.
- W4375950892 cites W1989230986 @default.
- W4375950892 cites W1994397669 @default.
- W4375950892 cites W2003555906 @default.
- W4375950892 cites W2006376003 @default.
- W4375950892 cites W2013470095 @default.
- W4375950892 cites W2014150467 @default.
- W4375950892 cites W2024963356 @default.
- W4375950892 cites W2034161096 @default.
- W4375950892 cites W2037132719 @default.
- W4375950892 cites W2040499978 @default.
- W4375950892 cites W2043737083 @default.
- W4375950892 cites W2054546290 @default.
- W4375950892 cites W2058652836 @default.
- W4375950892 cites W2059953274 @default.
- W4375950892 cites W2064296617 @default.
- W4375950892 cites W2066234893 @default.
- W4375950892 cites W2072738655 @default.
- W4375950892 cites W2079115644 @default.
- W4375950892 cites W2083492332 @default.
- W4375950892 cites W2090088751 @default.
- W4375950892 cites W2091250479 @default.
- W4375950892 cites W2096642458 @default.
- W4375950892 cites W2119810088 @default.
- W4375950892 cites W2123882607 @default.
- W4375950892 cites W2125411036 @default.
- W4375950892 cites W2137017984 @default.
- W4375950892 cites W2138977668 @default.
- W4375950892 cites W2146890278 @default.
- W4375950892 cites W2151341891 @default.
- W4375950892 cites W2155625566 @default.
- W4375950892 cites W2170852633 @default.
- W4375950892 cites W2222286644 @default.
- W4375950892 cites W2235679952 @default.
- W4375950892 cites W2288838295 @default.
- W4375950892 cites W2330361337 @default.
- W4375950892 cites W2336686065 @default.
- W4375950892 cites W2462764988 @default.
- W4375950892 cites W2515283883 @default.
- W4375950892 cites W2516348886 @default.
- W4375950892 cites W2548959977 @default.
- W4375950892 cites W2570534175 @default.
- W4375950892 cites W2606003614 @default.
- W4375950892 cites W2607253888 @default.
- W4375950892 cites W2739369295 @default.
- W4375950892 cites W2752462245 @default.
- W4375950892 cites W2753082054 @default.
- W4375950892 cites W2753794629 @default.
- W4375950892 cites W2754261921 @default.
- W4375950892 cites W2763397567 @default.
- W4375950892 cites W2790098401 @default.
- W4375950892 cites W2795171026 @default.
- W4375950892 cites W2795523469 @default.
- W4375950892 cites W2799348004 @default.
- W4375950892 cites W2803017118 @default.
- W4375950892 cites W2809170199 @default.
- W4375950892 cites W2886328984 @default.
- W4375950892 cites W2888790211 @default.
- W4375950892 cites W2891479021 @default.
- W4375950892 cites W2893115220 @default.
- W4375950892 cites W2897804429 @default.
- W4375950892 cites W2900756811 @default.
- W4375950892 cites W2901519529 @default.
- W4375950892 cites W2901780588 @default.
- W4375950892 cites W2901811281 @default.
- W4375950892 cites W2903517662 @default.
- W4375950892 cites W2913000824 @default.
- W4375950892 cites W2913905282 @default.
- W4375950892 cites W2915277729 @default.
- W4375950892 cites W2915989229 @default.
- W4375950892 cites W2916086178 @default.
- W4375950892 cites W2916217171 @default.
- W4375950892 cites W2923362583 @default.
- W4375950892 cites W2925493846 @default.
- W4375950892 cites W2937431312 @default.
- W4375950892 cites W2946284807 @default.
- W4375950892 cites W2946298500 @default.
- W4375950892 cites W2947057154 @default.
- W4375950892 cites W2950854031 @default.
- W4375950892 cites W2959261657 @default.
- W4375950892 cites W2970563580 @default.
- W4375950892 cites W2972368830 @default.
- W4375950892 cites W2974177021 @default.