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- W4375952462 endingPage "114401" @default.
- W4375952462 startingPage "114401" @default.
- W4375952462 abstract "PF-543 is a sphingosine kinase 1（SPHK1）inhibitor developed by Pfizer and is currently considered the most potent selective SPHK1 inhibitor. SPHK1 catalyses the production of sphingosine 1-phosphate (S1P) from sphingosine. It is the rate-limiting enzyme of S1P production, and there is substantial evidence to support a very important role for sphingosine kinase in health and disease. This review is the first to summarize the role and mechanisms of PF-543 as an SPHK1 inhibitor in anticancer, antifibrotic, and anti-inflammatory processes, providing new therapeutic leads and ideas for future research and clinical trials." @default.
- W4375952462 created "2023-05-10" @default.
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- W4375952462 date "2023-07-01" @default.
- W4375952462 modified "2023-10-16" @default.
- W4375952462 title "Therapeutic potential of the sphingosine kinase 1 inhibitor, PF-543" @default.
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