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• W4375954611 startingPage "1721" @default.
• W4375954611 abstract "H3K27M mutated diffuse midline gliomas (DMGs) are extremely aggressive and the leading cause of cancer-related deaths in pediatric brain tumors with 5-year survival <1%. Radiotherapy is the only established adjuvant treatment of H3K27M DMGs; however, the radio-resistance is commonly observed.We summarized current understandings of the molecular responses of H3K27M DMGs to radiotherapy and provide crucial insights into current advances in radiosensitivity enhancement.Ionizing radiation (IR) can mainly inhibit tumor cell growth by inducing DNA damage regulated by the cell cycle checkpoints and DNA damage repair (DDR) system. In H3K27M DMGs, the aberrant genetic and epigenetic changes, stemness genotype, and epithelial-mesenchymal transition (EMT) disrupt the cell cycle checkpoints and DDR system by altering the associated regulatory signaling pathways, which leads to the development of radio-resistance.The advances in mechanisms of radio-resistance in H3K27M DMGs promote the potential targets to enhance the sensitivity to radiotherapy." @default.
• W4375954611 created "2023-05-10" @default.
• W4375954611 creator A5001509020 @default.
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• W4375954611 creator A5036791089 @default.
• W4375954611 creator A5073920999 @default.
• W4375954611 creator A5077635359 @default.
• W4375954611 date "2023-05-08" @default.
• W4375954611 modified "2023-09-26" @default.
• W4375954611 title "Radiotherapy and radio‐sensitization in <scp><i>H3</i>^K27M</scp>‐mutated diffuse midline gliomas" @default.
• W4375954611 cites W1509901905 @default.
• W4375954611 cites W1553367038 @default.
• W4375954611 cites W1601758486 @default.
• W4375954611 cites W1780348968 @default.
• W4375954611 cites W1948249218 @default.
• W4375954611 cites W1955123431 @default.
• W4375954611 cites W1964327569 @default.
• W4375954611 cites W1964847767 @default.
• W4375954611 cites W1965239527 @default.
• W4375954611 cites W1965568527 @default.
• W4375954611 cites W1965980060 @default.
• W4375954611 cites W1967955844 @default.
• W4375954611 cites W1971361765 @default.
• W4375954611 cites W1973388314 @default.
• W4375954611 cites W1974631593 @default.
• W4375954611 cites W1974755980 @default.
• W4375954611 cites W1980767402 @default.
• W4375954611 cites W1985786559 @default.
• W4375954611 cites W1986247754 @default.
• W4375954611 cites W1987293747 @default.
• W4375954611 cites W1988280121 @default.
• W4375954611 cites W1994826332 @default.
• W4375954611 cites W1995105508 @default.
• W4375954611 cites W1995644713 @default.
• W4375954611 cites W1996382897 @default.
• W4375954611 cites W2002754034 @default.
• W4375954611 cites W2003422441 @default.
• W4375954611 cites W2005011349 @default.
• W4375954611 cites W2008171713 @default.
• W4375954611 cites W2012458297 @default.
• W4375954611 cites W2013420022 @default.
• W4375954611 cites W2017181626 @default.
• W4375954611 cites W2017229935 @default.
• W4375954611 cites W2021670941 @default.
• W4375954611 cites W2021726330 @default.
• W4375954611 cites W2024502310 @default.
• W4375954611 cites W2028643362 @default.
• W4375954611 cites W2030664470 @default.
• W4375954611 cites W2032794324 @default.
• W4375954611 cites W2035658420 @default.
• W4375954611 cites W2037867164 @default.
• W4375954611 cites W2039143648 @default.
• W4375954611 cites W2040288095 @default.
• W4375954611 cites W2041399911 @default.
• W4375954611 cites W2042841044 @default.
• W4375954611 cites W2043027414 @default.
• W4375954611 cites W2043403539 @default.
• W4375954611 cites W2044898192 @default.
• W4375954611 cites W2045836176 @default.
• W4375954611 cites W2049589513 @default.
• W4375954611 cites W2051921450 @default.
• W4375954611 cites W2053349906 @default.
• W4375954611 cites W2054694670 @default.
• W4375954611 cites W2057347757 @default.
• W4375954611 cites W2059060292 @default.
• W4375954611 cites W2060551076 @default.
• W4375954611 cites W2062062519 @default.
• W4375954611 cites W2065488592 @default.
• W4375954611 cites W2067427915 @default.
• W4375954611 cites W2068359474 @default.
• W4375954611 cites W2071457560 @default.
• W4375954611 cites W2072441383 @default.
• W4375954611 cites W2073100374 @default.
• W4375954611 cites W2074699503 @default.
• W4375954611 cites W2077436902 @default.
• W4375954611 cites W2078544177 @default.
• W4375954611 cites W2079204151 @default.
• W4375954611 cites W2079930439 @default.
• W4375954611 cites W2083081144 @default.
• W4375954611 cites W2084610805 @default.
• W4375954611 cites W2084885369 @default.
• W4375954611 cites W2091664468 @default.
• W4375954611 cites W2093676592 @default.
• W4375954611 cites W2094001485 @default.
• W4375954611 cites W2096083625 @default.
• W4375954611 cites W2096120057 @default.
• W4375954611 cites W2099923159 @default.
• W4375954611 cites W2100078246 @default.
• W4375954611 cites W2101775250 @default.
• W4375954611 cites W2102872615 @default.
• W4375954611 cites W2106343920 @default.
• W4375954611 cites W2106675906 @default.
• W4375954611 cites W2107733793 @default.
• W4375954611 cites W2109670573 @default.
• W4375954611 cites W2110265246 @default.
• W4375954611 cites W2110938265 @default.

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