FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4375954883> ?p ?o ?g. }

• W4375954883 abstract "Cephalic tetanus (CT) is a severe form of tetanus that follows head wounds and the intoxication of cranial nerves by tetanus neurotoxin (TeNT). Hallmarks of CT are cerebral palsy, which anticipates the spastic paralysis of tetanus, and rapid evolution of cardiorespiratory deficit even without generalized tetanus. How TeNT causes this unexpected flaccid paralysis, and how the canonical spasticity then rapidly evolves into cardiorespiratory defects, remain unresolved aspects of CT pathophysiology. Using electrophysiology and immunohistochemistry, we demonstrate that TeNT cleaves its substrate vesicle-associated membrane protein within facial neuromuscular junctions and causes a botulism-like paralysis overshadowing tetanus spasticity. Meanwhile, TeNT spreads among brainstem neuronal nuclei and, as shown by an assay measuring the ventilation ability of CT mice, harms essential functions like respiration. A partial axotomy of the facial nerve revealed a potentially new ability of TeNT to undergo intra-brainstem diffusion, which allows the toxin to spread to brainstem nuclei devoid of direct peripheral efferents. This mechanism is likely to be involved in the transition from local to generalized tetanus. Overall, the present findings suggest that patients with idiopathic facial nerve palsy should be immediately considered for CT and treated with antisera to block the potential progression to a life-threatening form of tetanus." @default.
• W4375954883 created "2023-05-10" @default.
• W4375954883 creator A5006738588 @default.
• W4375954883 creator A5032307663 @default.
• W4375954883 creator A5033851375 @default.
• W4375954883 creator A5063938722 @default.
• W4375954883 creator A5065776889 @default.
• W4375954883 creator A5072457581 @default.
• W4375954883 creator A5076153026 @default.
• W4375954883 creator A5076358524 @default.
• W4375954883 creator A5079736741 @default.
• W4375954883 creator A5080449532 @default.
• W4375954883 creator A5091033956 @default.
• W4375954883 date "2023-06-08" @default.
• W4375954883 modified "2023-09-30" @default.
• W4375954883 title "Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus" @default.
• W4375954883 cites W1531203206 @default.
• W4375954883 cites W1964729342 @default.
• W4375954883 cites W1974811041 @default.
• W4375954883 cites W1981764249 @default.
• W4375954883 cites W1985374275 @default.
• W4375954883 cites W1992464116 @default.
• W4375954883 cites W1997819162 @default.
• W4375954883 cites W2000856416 @default.
• W4375954883 cites W2004057888 @default.
• W4375954883 cites W2008596598 @default.
• W4375954883 cites W2032736876 @default.
• W4375954883 cites W2033500343 @default.
• W4375954883 cites W2055822860 @default.
• W4375954883 cites W2056746402 @default.
• W4375954883 cites W2058905710 @default.
• W4375954883 cites W2066248618 @default.
• W4375954883 cites W2070813646 @default.
• W4375954883 cites W2084051537 @default.
• W4375954883 cites W2097237256 @default.
• W4375954883 cites W2099968607 @default.
• W4375954883 cites W2143135103 @default.
• W4375954883 cites W2144215255 @default.
• W4375954883 cites W2147069468 @default.
• W4375954883 cites W2147252877 @default.
• W4375954883 cites W2147971371 @default.
• W4375954883 cites W2167008489 @default.
• W4375954883 cites W2172330776 @default.
• W4375954883 cites W2173417946 @default.
• W4375954883 cites W2194986993 @default.
• W4375954883 cites W2576923729 @default.
• W4375954883 cites W2598060151 @default.
• W4375954883 cites W2743118930 @default.
• W4375954883 cites W2794504653 @default.
• W4375954883 cites W2943466360 @default.
• W4375954883 cites W2949423434 @default.
• W4375954883 cites W2989717496 @default.
• W4375954883 cites W2991323335 @default.
• W4375954883 cites W3130760386 @default.
• W4375954883 cites W4207069321 @default.
• W4375954883 cites W4211236769 @default.
• W4375954883 cites W4220940294 @default.
• W4375954883 cites W4221015490 @default.
• W4375954883 cites W4223950904 @default.
• W4375954883 cites W4226241112 @default.
• W4375954883 cites W4292809392 @default.
• W4375954883 doi "https://doi.org/10.1172/jci.insight.166978" @default.
• W4375954883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37159261" @default.
• W4375954883 hasPublicationYear "2023" @default.
• W4375954883 type Work @default.
• W4375954883 citedByCount "0" @default.
• W4375954883 crossrefType "journal-article" @default.
• W4375954883 hasAuthorship W4375954883A5006738588 @default.
• W4375954883 hasAuthorship W4375954883A5032307663 @default.
• W4375954883 hasAuthorship W4375954883A5033851375 @default.
• W4375954883 hasAuthorship W4375954883A5063938722 @default.
• W4375954883 hasAuthorship W4375954883A5065776889 @default.
• W4375954883 hasAuthorship W4375954883A5072457581 @default.
• W4375954883 hasAuthorship W4375954883A5076153026 @default.
• W4375954883 hasAuthorship W4375954883A5076358524 @default.
• W4375954883 hasAuthorship W4375954883A5079736741 @default.
• W4375954883 hasAuthorship W4375954883A5080449532 @default.
• W4375954883 hasAuthorship W4375954883A5091033956 @default.
• W4375954883 hasBestOaLocation W43759548831 @default.
• W4375954883 hasConcept C105702510 @default.
• W4375954883 hasConcept C126322002 @default.
• W4375954883 hasConcept C142724271 @default.
• W4375954883 hasConcept C169760540 @default.
• W4375954883 hasConcept C22070199 @default.
• W4375954883 hasConcept C2777478456 @default.
• W4375954883 hasConcept C2778817116 @default.
• W4375954883 hasConcept C2778987478 @default.
• W4375954883 hasConcept C2779012798 @default.
• W4375954883 hasConcept C2779841045 @default.
• W4375954883 hasConcept C42219234 @default.
• W4375954883 hasConcept C551621295 @default.
• W4375954883 hasConcept C71924100 @default.
• W4375954883 hasConcept C86803240 @default.
• W4375954883 hasConceptScore W4375954883C105702510 @default.
• W4375954883 hasConceptScore W4375954883C126322002 @default.
• W4375954883 hasConceptScore W4375954883C142724271 @default.
• W4375954883 hasConceptScore W4375954883C169760540 @default.
• W4375954883 hasConceptScore W4375954883C22070199 @default.
• W4375954883 hasConceptScore W4375954883C2777478456 @default.
• W4375954883 hasConceptScore W4375954883C2778817116 @default.

• next