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- W4375955065 abstract "Homeostatic trafficking to lymph nodes allows T cells to efficiently survey the host for cognate antigen. Nonmammalian jawed vertebrates lack lymph nodes but maintain diverse T cell pools. Here, we exploit in vivo imaging of transparent zebrafish to investigate how T cells organize and survey for antigen in an animal devoid of lymph nodes. We find that naïve-like T cells in zebrafish organize into a previously undescribed whole-body lymphoid network that supports streaming migration and coordinated trafficking through the host. This network has the cellular hallmarks of a mammalian lymph node, including naïve T cells and CCR7-ligand expressing nonhematopoietic cells, and facilitates rapid collective migration. During infection, T cells transition to a random walk that supports antigen-presenting cell interactions and subsequent activation. Our results reveal that T cells can toggle between collective migration and individual random walks to prioritize either large-scale trafficking or antigen search in situ. This lymphoid network thus facilitates whole-body T cell trafficking and antigen surveillance in the absence of a lymph node system." @default.
- W4375955065 created "2023-05-10" @default.
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- W4375955065 date "2023-05-08" @default.
- W4375955065 modified "2023-09-28" @default.
- W4375955065 title "A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish" @default.
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- W4375955065 doi "https://doi.org/10.1073/pnas.2301137120" @default.
- W4375955065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37155881" @default.
- W4375955065 hasPublicationYear "2023" @default.
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