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- W4375955150 abstract "Abstract Whole-genome duplications (WGDs) have shaped the gene repertoire of many eukaryotic lineages. The redundancy created by WGDs typically results in a phase of massive gene loss. However, some WGD–derived paralogs are maintained over long evolutionary periods, and the relative contributions of different selective pressures to their maintenance are still debated. Previous studies have revealed a history of three successive WGDs in the lineage of the ciliate Paramecium tetraurelia and two of its sister species from the Paramecium aurelia complex. Here, we report the genome sequence and analysis of 10 additional P. aurelia species and 1 additional out group, revealing aspects of post-WGD evolution in 13 species sharing a common ancestral WGD. Contrary to the morphological radiation of vertebrates that putatively followed two WGD events, members of the cryptic P. aurelia complex have remained morphologically indistinguishable after hundreds of millions of years. Biases in gene retention compatible with dosage constraints appear to play a major role opposing post-WGD gene loss across all 13 species. In addition, post-WGD gene loss has been slower in Paramecium than in other species having experienced genome duplication, suggesting that the selective pressures against post-WGD gene loss are especially strong in Paramecium. A near complete lack of recent single-gene duplications in Paramecium provides additional evidence for strong selective pressures against gene dosage changes. This exceptional data set of 13 species sharing an ancestral WGD and 2 closely related out group species will be a useful resource for future studies on Paramecium as a major model organism in the evolutionary cell biology." @default.
- W4375955150 created "2023-05-10" @default.
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- W4375955150 date "2023-05-01" @default.
- W4375955150 modified "2023-10-16" @default.
- W4375955150 title "Dynamics of Gene Loss following Ancient Whole-Genome Duplication in the Cryptic <i>Paramecium</i> Complex" @default.
- W4375955150 cites W1519266993 @default.
- W4375955150 cites W1793984240 @default.
- W4375955150 cites W1875727809 @default.
- W4375955150 cites W1913751214 @default.
- W4375955150 cites W1963957860 @default.
- W4375955150 cites W1964612763 @default.
- W4375955150 cites W1967621400 @default.
- W4375955150 cites W1971231926 @default.
- W4375955150 cites W1981195576 @default.
- W4375955150 cites W1981239255 @default.
- W4375955150 cites W1983811433 @default.
- W4375955150 cites W1990819915 @default.
- W4375955150 cites W1991925880 @default.
- W4375955150 cites W2005777298 @default.
- W4375955150 cites W2019591778 @default.
- W4375955150 cites W2022472106 @default.
- W4375955150 cites W2034499270 @default.
- W4375955150 cites W2036897871 @default.
- W4375955150 cites W2041999282 @default.
- W4375955150 cites W2047405437 @default.
- W4375955150 cites W2055043387 @default.
- W4375955150 cites W2057652201 @default.
- W4375955150 cites W2058823843 @default.
- W4375955150 cites W2061507735 @default.
- W4375955150 cites W2064322162 @default.
- W4375955150 cites W2064912476 @default.
- W4375955150 cites W2065636600 @default.
- W4375955150 cites W2081933515 @default.
- W4375955150 cites W2085318451 @default.
- W4375955150 cites W2086983477 @default.
- W4375955150 cites W2091507729 @default.
- W4375955150 cites W2091642503 @default.
- W4375955150 cites W2098620174 @default.
- W4375955150 cites W2104046832 @default.
- W4375955150 cites W2110335151 @default.
- W4375955150 cites W2111318712 @default.
- W4375955150 cites W2111647009 @default.
- W4375955150 cites W2112451705 @default.
- W4375955150 cites W2116279310 @default.
- W4375955150 cites W2124985265 @default.
- W4375955150 cites W2130150686 @default.
- W4375955150 cites W2132926880 @default.
- W4375955150 cites W2135409136 @default.
- W4375955150 cites W2137845412 @default.
- W4375955150 cites W2139736670 @default.
- W4375955150 cites W2140729960 @default.
- W4375955150 cites W2141458291 @default.
- W4375955150 cites W2143157299 @default.
- W4375955150 cites W2149531726 @default.
- W4375955150 cites W2152075687 @default.
- W4375955150 cites W2152876917 @default.
- W4375955150 cites W2165990439 @default.
- W4375955150 cites W2168543111 @default.
- W4375955150 cites W2181112699 @default.
- W4375955150 cites W2187590948 @default.
- W4375955150 cites W2526255529 @default.
- W4375955150 cites W2534919910 @default.
- W4375955150 cites W2540502353 @default.
- W4375955150 cites W2569610240 @default.
- W4375955150 cites W2680409361 @default.
- W4375955150 cites W2737631629 @default.
- W4375955150 cites W2781873368 @default.
- W4375955150 cites W2795227840 @default.
- W4375955150 cites W2804077814 @default.
- W4375955150 cites W2885295334 @default.
- W4375955150 cites W2903005412 @default.
- W4375955150 cites W2953169567 @default.
- W4375955150 cites W2953361113 @default.
- W4375955150 cites W3016521585 @default.
- W4375955150 cites W3184036930 @default.
- W4375955150 cites W4229487902 @default.
- W4375955150 cites W4255604776 @default.
- W4375955150 cites W4282941452 @default.
- W4375955150 cites W4297601343 @default.
- W4375955150 doi "https://doi.org/10.1093/molbev/msad107" @default.
- W4375955150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37154524" @default.
- W4375955150 hasPublicationYear "2023" @default.
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