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• W4375956039 startingPage "6798" @default.
• W4375956039 abstract "Trioxacarcin (TXN) A was reported to be an anticancer agent through alkylation of dsDNA. G-quadruplex DNA (G4-DNA) is frequently formed in the promoter regions of oncogenes and the ends of telomerase genes, considered as promising drug targets for anticancer therapy. There are no reports about TXN A interactions with G4-DNA. Here, we tested TXN A’s interactions with several G4-DNA oligos with parallel, antiparallel, or hybrid folding, respectively. We demonstrated that TXN A preferred to alkylate one flexible guanine in the loops of parallel G4-DNA. The position of the alkylated guanine is in favor of interactions of G4-DNA with TXN A. The structure of TXN A covalently bound RET G4-DNA indicated that TXN A alkylation on RET G4-DNA stabilizes the G4-DNA conformation. These studies opened a new window of how TXN A interacted with G4-DNA, which might hint a new mode of its function as an anticancer agent." @default.
• W4375956039 created "2023-05-10" @default.
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• W4375956039 date "2023-05-08" @default.
• W4375956039 modified "2023-10-15" @default.
• W4375956039 title "Trioxacarcin A Interactions with G-Quadruplex DNA Reveal Its Potential New Targets as an Anticancer Agent" @default.
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• W4375956039 doi "https://doi.org/10.1021/acs.jmedchem.3c00178" @default.
• W4375956039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37154782" @default.
• W4375956039 hasPublicationYear "2023" @default.
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