FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376104397> ?p ?o ?g. }

• W4376104397 abstract "Abstract Bats have unique characteristics compared to other mammals, including increased longevity and higher resistance to cancer and infectious disease. While previous studies have analyzed the metabolic requirements for flight, it is still unclear how bat metabolism supports these unique features, and no study has integrated metabolomics, transcriptomics, and proteomics to characterize bat metabolism. In this work, we performed a multi-omics data analysis using a computational model of metabolic fluxes to identify fundamental differences in central metabolism between primary lung fibroblast cell lines from the black flying fox fruit bat ( Pteropus alecto ) and human. Bat cells showed higher expression levels of Complex I components of electron transport chain (ETC), but, remarkably, a lower rate of oxygen consumption (OCR). Computational modeling interpreted these results as indicating that Complex II activity may be low or reversed, similar to an ischemic state. An ischemic-like state of bats was also supported by decreased levels of central metabolites and increased ratios of succinate to fumarate in bat cells. Ischemic states tend to produce reactive oxygen species (ROS), which would be incompatible with the longevity of bats. However, bat cells had higher antioxidant reservoirs (higher total glutathione and higher ratio of NADPH to NADP) despite higher mitochondrial ROS levels. In addition, bat cells were more resistant to glucose deprivation and had increased resistance to ferroptosis, one of the characteristics of which is oxidative stress. Thus, our studies revealed distinct differences in the ETC regulation and metabolic stress responses between human and bat cells." @default.
• W4376104397 created "2023-05-12" @default.
• W4376104397 creator A5013128428 @default.
• W4376104397 creator A5017602320 @default.
• W4376104397 creator A5030277810 @default.
• W4376104397 creator A5031212703 @default.
• W4376104397 creator A5031384457 @default.
• W4376104397 creator A5031864344 @default.
• W4376104397 creator A5044909515 @default.
• W4376104397 creator A5049518482 @default.
• W4376104397 creator A5057957774 @default.
• W4376104397 date "2023-05-09" @default.
• W4376104397 modified "2023-09-30" @default.
• W4376104397 title "Multi-omic analysis of bat versus human fibroblasts reveals altered central metabolism" @default.
• W4376104397 cites W1587804137 @default.
• W4376104397 cites W1965713319 @default.
• W4376104397 cites W1969409342 @default.
• W4376104397 cites W1982194470 @default.
• W4376104397 cites W1992492911 @default.
• W4376104397 cites W1998871189 @default.
• W4376104397 cites W2021761926 @default.
• W4376104397 cites W2023552355 @default.
• W4376104397 cites W2028232771 @default.
• W4376104397 cites W2058691436 @default.
• W4376104397 cites W2098428536 @default.
• W4376104397 cites W2104603317 @default.
• W4376104397 cites W2109539269 @default.
• W4376104397 cites W2114104545 @default.
• W4376104397 cites W2115949387 @default.
• W4376104397 cites W2122091775 @default.
• W4376104397 cites W2122658763 @default.
• W4376104397 cites W2128733166 @default.
• W4376104397 cites W2130410032 @default.
• W4376104397 cites W2130850760 @default.
• W4376104397 cites W2137464714 @default.
• W4376104397 cites W2159675211 @default.
• W4376104397 cites W2169746292 @default.
• W4376104397 cites W2179438025 @default.
• W4376104397 cites W2180760460 @default.
• W4376104397 cites W2344994267 @default.
• W4376104397 cites W2521662433 @default.
• W4376104397 cites W2548864808 @default.
• W4376104397 cites W2554533082 @default.
• W4376104397 cites W2745688516 @default.
• W4376104397 cites W2762019694 @default.
• W4376104397 cites W2770847706 @default.
• W4376104397 cites W2788834659 @default.
• W4376104397 cites W2795652047 @default.
• W4376104397 cites W2809514549 @default.
• W4376104397 cites W2893339118 @default.
• W4376104397 cites W2900569176 @default.
• W4376104397 cites W2916116386 @default.
• W4376104397 cites W2949726389 @default.
• W4376104397 cites W2949753982 @default.
• W4376104397 cites W2951692437 @default.
• W4376104397 cites W2953478433 @default.
• W4376104397 cites W3010169670 @default.
• W4376104397 cites W3012295934 @default.
• W4376104397 cites W3021799469 @default.
• W4376104397 cites W3122818329 @default.
• W4376104397 cites W3130508053 @default.
• W4376104397 cites W3188804152 @default.
• W4376104397 cites W3210906481 @default.
• W4376104397 cites W3213751857 @default.
• W4376104397 cites W4317660914 @default.
• W4376104397 doi "https://doi.org/10.1101/2023.05.08.537600" @default.
• W4376104397 hasPublicationYear "2023" @default.
• W4376104397 type Work @default.
• W4376104397 citedByCount "0" @default.
• W4376104397 crossrefType "posted-content" @default.
• W4376104397 hasAuthorship W4376104397A5013128428 @default.
• W4376104397 hasAuthorship W4376104397A5017602320 @default.
• W4376104397 hasAuthorship W4376104397A5030277810 @default.
• W4376104397 hasAuthorship W4376104397A5031212703 @default.
• W4376104397 hasAuthorship W4376104397A5031384457 @default.
• W4376104397 hasAuthorship W4376104397A5031864344 @default.
• W4376104397 hasAuthorship W4376104397A5044909515 @default.
• W4376104397 hasAuthorship W4376104397A5049518482 @default.
• W4376104397 hasAuthorship W4376104397A5057957774 @default.
• W4376104397 hasBestOaLocation W43761043971 @default.
• W4376104397 hasConcept C104317684 @default.
• W4376104397 hasConcept C150194340 @default.
• W4376104397 hasConcept C162317418 @default.
• W4376104397 hasConcept C17093226 @default.
• W4376104397 hasConcept C181199279 @default.
• W4376104397 hasConcept C20251656 @default.
• W4376104397 hasConcept C21565614 @default.
• W4376104397 hasConcept C2776151105 @default.
• W4376104397 hasConcept C2778004101 @default.
• W4376104397 hasConcept C28859421 @default.
• W4376104397 hasConcept C46111723 @default.
• W4376104397 hasConcept C48349386 @default.
• W4376104397 hasConcept C538909803 @default.
• W4376104397 hasConcept C55493867 @default.
• W4376104397 hasConcept C60644358 @default.
• W4376104397 hasConcept C62231903 @default.
• W4376104397 hasConcept C86803240 @default.
• W4376104397 hasConcept C95444343 @default.
• W4376104397 hasConceptScore W4376104397C104317684 @default.
• W4376104397 hasConceptScore W4376104397C150194340 @default.

• next