Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376105055> ?p ?o ?g. }
- W4376105055 abstract "Abstract Background A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency of breeding for improved production merit in beef cattle. To prioritize the putative variants and genes, we ran a comprehensive genome-wide association studies (GWAS) analysis for 21 agronomic traits using imputed whole-genome variants in Simmental beef cattle. Then, we applied expression quantitative trait loci (eQTL) mapping between the genotype variants and transcriptome of three tissues ( longissimus dorsi muscle, backfat, and liver) in 120 cattle. Results We identified 1,580 association signals for 21 beef agronomic traits using GWAS. We then illuminated 854,498 cis -eQTLs for 6,017 genes and 46,970 trans -eQTLs for 1,903 genes in three tissues and built a synergistic network by integrating transcriptomics with agronomic traits. These cis -eQTLs were preferentially close to the transcription start site and enriched in functional regulatory regions. We observed an average of 43.5% improvement in cis -eQTL discovery using multi-tissue eQTL mapping. Fine-mapping analysis revealed that 111, 192, and 194 variants were most likely to be causative to regulate gene expression in backfat, liver, and muscle, respectively. The transcriptome-wide association studies identified 722 genes significantly associated with 11 agronomic traits. Via the colocalization and Mendelian randomization analyses, we found that eQTLs of several genes were associated with the GWAS signals of agronomic traits in three tissues, which included genes, such as NADSYN1 , NDUFS3 , LTF and KIFC2 in liver, GRAMD1C, TMTC2 and ZNF613 in backfat, as well as TIGAR, NDUFS3 and L3HYPDH in muscle that could serve as the candidate genes for economic traits. Conclusions The extensive atlas of GWAS, eQTL, fine-mapping, and transcriptome-wide association studies aid in the suggestion of potentially functional variants and genes in cattle agronomic traits and will be an invaluable source for genomics and breeding in beef cattle." @default.
- W4376105055 created "2023-05-12" @default.
- W4376105055 creator A5000250239 @default.
- W4376105055 creator A5006472198 @default.
- W4376105055 creator A5008708530 @default.
- W4376105055 creator A5010929925 @default.
- W4376105055 creator A5016113685 @default.
- W4376105055 creator A5018090532 @default.
- W4376105055 creator A5022101847 @default.
- W4376105055 creator A5037458498 @default.
- W4376105055 creator A5044571364 @default.
- W4376105055 creator A5053042942 @default.
- W4376105055 creator A5070661880 @default.
- W4376105055 creator A5072383638 @default.
- W4376105055 date "2023-05-11" @default.
- W4376105055 modified "2023-10-09" @default.
- W4376105055 title "The eQTL colocalization and transcriptome-wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle" @default.
- W4376105055 cites W1516383433 @default.
- W4376105055 cites W1533942137 @default.
- W4376105055 cites W1964895626 @default.
- W4376105055 cites W1966327575 @default.
- W4376105055 cites W1980383233 @default.
- W4376105055 cites W1986911601 @default.
- W4376105055 cites W1993671575 @default.
- W4376105055 cites W1998342895 @default.
- W4376105055 cites W2005967671 @default.
- W4376105055 cites W2033151532 @default.
- W4376105055 cites W2036897871 @default.
- W4376105055 cites W2042421957 @default.
- W4376105055 cites W2061272721 @default.
- W4376105055 cites W2066165525 @default.
- W4376105055 cites W2069633173 @default.
- W4376105055 cites W2073836327 @default.
- W4376105055 cites W2098667422 @default.
- W4376105055 cites W2100697281 @default.
- W4376105055 cites W2102992354 @default.
- W4376105055 cites W2104005232 @default.
- W4376105055 cites W2106036991 @default.
- W4376105055 cites W2108744961 @default.
- W4376105055 cites W2111145766 @default.
- W4376105055 cites W2118198990 @default.
- W4376105055 cites W2127808488 @default.
- W4376105055 cites W2131271579 @default.
- W4376105055 cites W2140744595 @default.
- W4376105055 cites W2158804744 @default.
- W4376105055 cites W2161245845 @default.
- W4376105055 cites W2161633633 @default.
- W4376105055 cites W2171863224 @default.
- W4376105055 cites W2183412811 @default.
- W4376105055 cites W2241686927 @default.
- W4376105055 cites W2264585211 @default.
- W4376105055 cites W2328393125 @default.
- W4376105055 cites W2346964229 @default.
- W4376105055 cites W2400221198 @default.
- W4376105055 cites W2417483443 @default.
- W4376105055 cites W2525152921 @default.
- W4376105055 cites W2546472742 @default.
- W4376105055 cites W2592004722 @default.
- W4376105055 cites W2761275051 @default.
- W4376105055 cites W2796081119 @default.
- W4376105055 cites W2803008577 @default.
- W4376105055 cites W2811460312 @default.
- W4376105055 cites W2892114797 @default.
- W4376105055 cites W2899867539 @default.
- W4376105055 cites W2902196707 @default.
- W4376105055 cites W2907021876 @default.
- W4376105055 cites W2934861239 @default.
- W4376105055 cites W2937496270 @default.
- W4376105055 cites W2944758784 @default.
- W4376105055 cites W2950235747 @default.
- W4376105055 cites W2951130888 @default.
- W4376105055 cites W2952553874 @default.
- W4376105055 cites W2953285308 @default.
- W4376105055 cites W2964849163 @default.
- W4376105055 cites W2965651117 @default.
- W4376105055 cites W2965802689 @default.
- W4376105055 cites W2975065612 @default.
- W4376105055 cites W2991517562 @default.
- W4376105055 cites W3000298699 @default.
- W4376105055 cites W3008404350 @default.
- W4376105055 cites W3010437724 @default.
- W4376105055 cites W3082588124 @default.
- W4376105055 cites W3083107626 @default.
- W4376105055 cites W3087029872 @default.
- W4376105055 cites W3127497932 @default.
- W4376105055 cites W3129419315 @default.
- W4376105055 cites W3133859624 @default.
- W4376105055 cites W3138373478 @default.
- W4376105055 cites W3160514922 @default.
- W4376105055 cites W3197364483 @default.
- W4376105055 cites W3197367468 @default.
- W4376105055 cites W3215281550 @default.
- W4376105055 cites W3217420661 @default.
- W4376105055 cites W4205777871 @default.
- W4376105055 cites W4214591355 @default.
- W4376105055 cites W4221096971 @default.
- W4376105055 cites W4280644477 @default.
- W4376105055 cites W4292865342 @default.
- W4376105055 cites W4307043817 @default.
- W4376105055 cites W4307953159 @default.