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- W4376105881 abstract "Abstract The generation and propagation of physical signals in living biosystems are continuous issues. Traditional Hodgkin-Huxley model based on ionic current conduction could not explain the fast transmission of action potential in myelinated axons and factors influencing AP velocity. We propose that the ion distribution variation induced by sodium channel generates near field quasi-static electric field at extracellular space, termed as an ephaptic field which is able to excite nearby passive axons. Our simulation reveals the static electric field generated by sodium ion channels in one node of Ranvier is unlikely to activate the ion channels at nearest neighbor node. However, the ion channels ring on a node could induce 0.01 mV membrane potential difference on the node at nearby axon located at the middle of the two nodes, assuming the internode distance is 100 μm. Together with the superposition of ephaptic feedback field by the collective motion of many neighbor parallel axons, which could activate the next node of the original axon, the action potential could propagate in a zigzag path. Our simulation result also explain the fast speed of action potential propagation observed in experiments." @default.
- W4376105881 created "2023-05-12" @default.
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- W4376105881 date "2023-05-10" @default.
- W4376105881 modified "2023-10-01" @default.
- W4376105881 title "Possible mechanism of action potential propagation mediated by electric field: A novel assumption of understanding nerve interaction and ephaptic coupling" @default.
- W4376105881 doi "https://doi.org/10.21203/rs.3.rs-2880780/v1" @default.
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