FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376108454> ?p ?o ?g. }

• W4376108454 abstract "Summary Adult stem cells play a critical role in tissue repair and maintenance. In tissues with slow turnover, including skeletal muscle, these cells are maintained in a mitotically quiescent state yet remain poised to re-enter the cell cycle to replenish themselves and regenerate the tissue. Using a multiomics approach we identify the PAX7/NEDD4L axis as a checkpoint against muscle stem cell activation in homeostatic skeletal muscle. Our findings demonstrate that PAX7 transcriptionally activates the E3 ubiquitin ligase Nedd4L and that the conditional genetic deletion of Nedd4L impairs muscle stem cell quiescence, with an upregulation of cell cycle and myogenic differentiation genes. Loss of Nedd4L in muscle stem cells results in the expression of DCX which is only expressed during their in vivo activation. Together, this data establishes that the ubiquitin proteasome system, mediated by Nedd4L, is a key regulator of the muscle stem cell quiescent state in non-injured skeletal muscle. Highlights - General inhibition of the ubiquitin proteasome system with MG132 results in muscle stem cells (MuSCs) breaking quiescence. - The E3 ubiquitin ligase Nedd4L is a transcriptional target of Pax7. - The Pax7/Nedd4l axis restricts MuSC activation in homeostatic skeletal muscle. - Genetic deletion of Nedd4L induces MuSCs’ transition towards activation." @default.
• W4376108454 created "2023-05-12" @default.
• W4376108454 creator A5003522677 @default.
• W4376108454 creator A5020560286 @default.
• W4376108454 creator A5022580269 @default.
• W4376108454 creator A5023294856 @default.
• W4376108454 creator A5033383913 @default.
• W4376108454 creator A5035888169 @default.
• W4376108454 creator A5041621560 @default.
• W4376108454 creator A5042342171 @default.
• W4376108454 creator A5052482549 @default.
• W4376108454 creator A5064651221 @default.
• W4376108454 creator A5075841125 @default.
• W4376108454 creator A5081321256 @default.
• W4376108454 creator A5083363037 @default.
• W4376108454 date "2023-05-10" @default.
• W4376108454 modified "2023-10-18" @default.
• W4376108454 title "The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells" @default.
• W4376108454 cites W1964204876 @default.
• W4376108454 cites W1967114867 @default.
• W4376108454 cites W1972659631 @default.
• W4376108454 cites W1978159913 @default.
• W4376108454 cites W1993085259 @default.
• W4376108454 cites W2003647187 @default.
• W4376108454 cites W2003995400 @default.
• W4376108454 cites W2009100350 @default.
• W4376108454 cites W2019101092 @default.
• W4376108454 cites W2029914169 @default.
• W4376108454 cites W2031126348 @default.
• W4376108454 cites W2045273788 @default.
• W4376108454 cites W2052006216 @default.
• W4376108454 cites W2063511140 @default.
• W4376108454 cites W2067657178 @default.
• W4376108454 cites W2071962567 @default.
• W4376108454 cites W2074106315 @default.
• W4376108454 cites W2075670261 @default.
• W4376108454 cites W2082985952 @default.
• W4376108454 cites W2092090368 @default.
• W4376108454 cites W2093146349 @default.
• W4376108454 cites W2096622475 @default.
• W4376108454 cites W2097689258 @default.
• W4376108454 cites W2102278945 @default.
• W4376108454 cites W2105184815 @default.
• W4376108454 cites W2108234281 @default.
• W4376108454 cites W2118375550 @default.
• W4376108454 cites W2121266842 @default.
• W4376108454 cites W2122795085 @default.
• W4376108454 cites W2125253058 @default.
• W4376108454 cites W2131271579 @default.
• W4376108454 cites W2132416790 @default.
• W4376108454 cites W2150159295 @default.
• W4376108454 cites W2150386847 @default.
• W4376108454 cites W2154010277 @default.
• W4376108454 cites W2161500245 @default.
• W4376108454 cites W2171808845 @default.
• W4376108454 cites W2179438025 @default.
• W4376108454 cites W2202628895 @default.
• W4376108454 cites W2224270925 @default.
• W4376108454 cites W2323326409 @default.
• W4376108454 cites W2341539131 @default.
• W4376108454 cites W2418024629 @default.
• W4376108454 cites W2524106150 @default.
• W4376108454 cites W2606992329 @default.
• W4376108454 cites W2609934552 @default.
• W4376108454 cites W2730614208 @default.
• W4376108454 cites W2750416916 @default.
• W4376108454 cites W2762997208 @default.
• W4376108454 cites W2769123411 @default.
• W4376108454 cites W2770760899 @default.
• W4376108454 cites W2884115197 @default.
• W4376108454 cites W2900402493 @default.
• W4376108454 cites W2911725572 @default.
• W4376108454 cites W2921993406 @default.
• W4376108454 cites W2942513301 @default.
• W4376108454 cites W2942732239 @default.
• W4376108454 cites W2971559821 @default.
• W4376108454 cites W2982159487 @default.
• W4376108454 cites W2989630849 @default.
• W4376108454 cites W2989712850 @default.
• W4376108454 cites W3009732833 @default.
• W4376108454 cites W3085918938 @default.
• W4376108454 cites W3092475087 @default.
• W4376108454 cites W3099896219 @default.
• W4376108454 cites W3111061871 @default.
• W4376108454 cites W3126866898 @default.
• W4376108454 cites W3131055609 @default.
• W4376108454 cites W3153549711 @default.
• W4376108454 cites W3158677772 @default.
• W4376108454 cites W3196575946 @default.
• W4376108454 cites W3213946816 @default.
• W4376108454 cites W4211197468 @default.
• W4376108454 cites W4220780146 @default.
• W4376108454 cites W4224943334 @default.
• W4376108454 cites W4232909036 @default.
• W4376108454 cites W4241183697 @default.
• W4376108454 cites W4283815865 @default.
• W4376108454 cites W4284960909 @default.
• W4376108454 cites W4285156857 @default.
• W4376108454 cites W4292430047 @default.
• W4376108454 cites W4292646795 @default.

• next