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• W4376108889 abstract "ABSTRACT In vertebrates, olfactory receptors localize on multiple cilia elaborated on dendritic knobs of olfactory sensory neurons (OSNs). Although olfactory cilia dysfunction can cause anosmia, how their differentiation is programmed at the transcriptional level has remained largely unexplored. We discovered in zebrafish and mice that Foxj1, a forkhead domain-containing transcription factor linked with motile cilia biogenesis, is expressed in OSNs and required for olfactory epithelium (OE) formation. In keeping with the immotile nature of olfactory cilia, we observed that ciliary motility genes are repressed in zebrafish, mouse, and human OSNs. Strikingly, we also found that besides ciliogenesis, Foxj1 controls the differentiation of the OSNs themselves by regulating their cell type-specific gene expression, such as that of olfactory marker protein ( omp ) involved in odor-evoked signal transduction. In line with this, response to bile acid, an odor detected by OMP-positive OSNs, was significantly diminished in foxj1 mutant zebrafish. Taken together, our findings establish how the canonical Foxj1-mediated motile ciliogenic transcriptional program has been repurposed for the biogenesis of immotile olfactory cilia and for development of the OSNs." @default.
• W4376108889 created "2023-05-12" @default.
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• W4376108889 date "2023-05-10" @default.
• W4376108889 modified "2023-10-17" @default.
• W4376108889 title "Foxj1 controls olfactory ciliogenesis and differentiation program of the olfactory sensory neurons" @default.
• W4376108889 cites W1495831712 @default.
• W4376108889 cites W1528612804 @default.
• W4376108889 cites W1835374993 @default.
• W4376108889 cites W1850145960 @default.
• W4376108889 cites W1963607937 @default.
• W4376108889 cites W1963753120 @default.
• W4376108889 cites W1969182723 @default.
• W4376108889 cites W1977905146 @default.
• W4376108889 cites W1983575054 @default.
• W4376108889 cites W1983831423 @default.
• W4376108889 cites W1984066507 @default.
• W4376108889 cites W1992938999 @default.
• W4376108889 cites W1994076532 @default.
• W4376108889 cites W1997668305 @default.
• W4376108889 cites W2001245581 @default.
• W4376108889 cites W2002523290 @default.
• W4376108889 cites W2009045981 @default.
• W4376108889 cites W2011378590 @default.
• W4376108889 cites W2016262076 @default.
• W4376108889 cites W2017143895 @default.
• W4376108889 cites W2017224987 @default.
• W4376108889 cites W2019848990 @default.
• W4376108889 cites W2027727992 @default.
• W4376108889 cites W2027845917 @default.
• W4376108889 cites W2030570400 @default.
• W4376108889 cites W2036582717 @default.
• W4376108889 cites W2038094327 @default.
• W4376108889 cites W2040010694 @default.
• W4376108889 cites W2040119784 @default.
• W4376108889 cites W2040241605 @default.
• W4376108889 cites W2047678214 @default.
• W4376108889 cites W2050879570 @default.
• W4376108889 cites W2051685988 @default.
• W4376108889 cites W2057652849 @default.
• W4376108889 cites W2060922035 @default.
• W4376108889 cites W2063276998 @default.
• W4376108889 cites W2069089843 @default.
• W4376108889 cites W2079755276 @default.
• W4376108889 cites W2080320300 @default.
• W4376108889 cites W2081088798 @default.
• W4376108889 cites W2082683558 @default.
• W4376108889 cites W2091247660 @default.
• W4376108889 cites W2095436637 @default.
• W4376108889 cites W2096441981 @default.
• W4376108889 cites W2103344845 @default.
• W4376108889 cites W2106974809 @default.
• W4376108889 cites W2110772590 @default.
• W4376108889 cites W2113562966 @default.
• W4376108889 cites W2118417588 @default.
• W4376108889 cites W2127613537 @default.
• W4376108889 cites W2138069365 @default.
• W4376108889 cites W2138207763 @default.
• W4376108889 cites W2151843654 @default.
• W4376108889 cites W2152523782 @default.
• W4376108889 cites W2156354373 @default.
• W4376108889 cites W2165134997 @default.
• W4376108889 cites W2166594626 @default.
• W4376108889 cites W2179438025 @default.
• W4376108889 cites W2195967731 @default.
• W4376108889 cites W2424318634 @default.
• W4376108889 cites W2527833694 @default.
• W4376108889 cites W2561670917 @default.
• W4376108889 cites W2590310168 @default.
• W4376108889 cites W2782457285 @default.
• W4376108889 cites W2790796918 @default.
• W4376108889 cites W2794480084 @default.
• W4376108889 cites W2800721149 @default.
• W4376108889 cites W2883575305 @default.
• W4376108889 cites W2890558202 @default.
• W4376108889 cites W2898574929 @default.
• W4376108889 cites W2898810121 @default.
• W4376108889 cites W2908047046 @default.
• W4376108889 cites W2918385837 @default.
• W4376108889 cites W2949177718 @default.
• W4376108889 cites W2951411842 @default.
• W4376108889 cites W2969719419 @default.
• W4376108889 cites W2998252679 @default.
• W4376108889 cites W3006474680 @default.
• W4376108889 cites W3025461411 @default.

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