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- W4376109743 endingPage "188910" @default.
- W4376109743 startingPage "188910" @default.
- W4376109743 abstract "The anti-cancer efficacy of anti-malignancy therapies is related to DNA damage. However, DNA damage-response mechanisms can repair DNA damage, failing anti-tumor therapy. The resistance to chemotherapy, radiotherapy, and immunotherapy remains a clinical challenge. Thus, new strategies to overcome these therapeutic resistance mechanisms are needed. DNA damage repair inhibitors (DDRis) continue to be investigated, with polyadenosine diphosphate ribose polymerase inhibitors being the most studied inhibitors. Evidence of their clinical benefits and therapeutic potential in preclinical studies is growing. In addition to their potential as a monotherapy, DDRis may play an important synergistic role with other anti-cancer therapies or in reversing acquired treatment resistance. Here we review the impact of DDRis on solid tumors and the potential value of combinations of different treatment modalities with DDRis for solid tumors." @default.
- W4376109743 created "2023-05-12" @default.
- W4376109743 creator A5005553860 @default.
- W4376109743 creator A5016065769 @default.
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- W4376109743 creator A5050218543 @default.
- W4376109743 creator A5057995628 @default.
- W4376109743 creator A5074303483 @default.
- W4376109743 creator A5087855509 @default.
- W4376109743 date "2023-07-01" @default.
- W4376109743 modified "2023-10-03" @default.
- W4376109743 title "Enhancing the anti-tumor response by combining DNA damage repair inhibitors in the treatment of solid tumors" @default.
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