Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376112612> ?p ?o ?g. }
- W4376112612 abstract "Traumatic brain injury (TBI) is a major public health concern particularly in adolescents who have a higher mortality and incidence of visual pathway injury compared to adult patients. Likewise, we have found disparities between adult and adolescent TBI outcomes in rodents. Most interestingly, adolescents suffer a prolonged apneic period immediately post injury leading to higher mortality; so, we implemented a brief oxygen exposure paradigm to circumvent this increased mortality. Adolescent male mice experienced a closed-head weight-drop TBI then were exposed to 100% O 2 until normal breathing returned or recovered in room air. We followed mice for 7- and 30-days and assessed their optokinetic response; retinal ganglion cell loss; axonal degeneration; glial reactivity; and retinal ER stress protein levels. O 2 reduced adolescent mortality by 40%, improved post-injury visual acuity, and reduced axonal degeneration and gliosis in optic projection regions. ER stress protein expression was altered in injured mice, and mice given O 2 utilized different ER-stress pathways in a time dependent manner. Finally, O 2 exposure may be mediating these ER stress responses through regulation of the redox-sensitive ER folding protein ERO1α, which has been linked to a reduction in the toxic effects of free radicals in other animal models of ER stress." @default.
- W4376112612 created "2023-05-12" @default.
- W4376112612 creator A5022375241 @default.
- W4376112612 creator A5026651973 @default.
- W4376112612 creator A5060501780 @default.
- W4376112612 date "2023-05-09" @default.
- W4376112612 modified "2023-10-17" @default.
- W4376112612 title "Brief oxygen exposure after traumatic brain injury speeds recovery and promotes adaptive chronic endoplasmic reticulum stress responses" @default.
- W4376112612 cites W1888762249 @default.
- W4376112612 cites W1976147378 @default.
- W4376112612 cites W1978159035 @default.
- W4376112612 cites W1982003884 @default.
- W4376112612 cites W1987537450 @default.
- W4376112612 cites W1988800702 @default.
- W4376112612 cites W1994103992 @default.
- W4376112612 cites W1998726711 @default.
- W4376112612 cites W2000086500 @default.
- W4376112612 cites W2002207827 @default.
- W4376112612 cites W2004193429 @default.
- W4376112612 cites W2009532273 @default.
- W4376112612 cites W2011455323 @default.
- W4376112612 cites W2015901248 @default.
- W4376112612 cites W2016668509 @default.
- W4376112612 cites W2026056461 @default.
- W4376112612 cites W2027203208 @default.
- W4376112612 cites W2028945502 @default.
- W4376112612 cites W2030796131 @default.
- W4376112612 cites W2031145156 @default.
- W4376112612 cites W2042776153 @default.
- W4376112612 cites W2046217999 @default.
- W4376112612 cites W2061812167 @default.
- W4376112612 cites W2067924267 @default.
- W4376112612 cites W2068944453 @default.
- W4376112612 cites W2074471441 @default.
- W4376112612 cites W2074551024 @default.
- W4376112612 cites W2081319561 @default.
- W4376112612 cites W2083278580 @default.
- W4376112612 cites W2087847672 @default.
- W4376112612 cites W2090035193 @default.
- W4376112612 cites W2093170571 @default.
- W4376112612 cites W2093879881 @default.
- W4376112612 cites W2095889022 @default.
- W4376112612 cites W2096061382 @default.
- W4376112612 cites W2099540110 @default.
- W4376112612 cites W2106172512 @default.
- W4376112612 cites W2115706326 @default.
- W4376112612 cites W2119506154 @default.
- W4376112612 cites W2121275412 @default.
- W4376112612 cites W2122071452 @default.
- W4376112612 cites W2143636139 @default.
- W4376112612 cites W2155580597 @default.
- W4376112612 cites W2163658559 @default.
- W4376112612 cites W2165804706 @default.
- W4376112612 cites W2165859838 @default.
- W4376112612 cites W2166754860 @default.
- W4376112612 cites W2169344296 @default.
- W4376112612 cites W2177417174 @default.
- W4376112612 cites W2210128369 @default.
- W4376112612 cites W2292633092 @default.
- W4376112612 cites W2317877264 @default.
- W4376112612 cites W2408866266 @default.
- W4376112612 cites W2414075168 @default.
- W4376112612 cites W2503817556 @default.
- W4376112612 cites W2506540428 @default.
- W4376112612 cites W2593620534 @default.
- W4376112612 cites W2757550808 @default.
- W4376112612 cites W2774459483 @default.
- W4376112612 cites W2785536580 @default.
- W4376112612 cites W2791254714 @default.
- W4376112612 cites W2795839837 @default.
- W4376112612 cites W2802921980 @default.
- W4376112612 cites W2805817817 @default.
- W4376112612 cites W2810613300 @default.
- W4376112612 cites W2887566254 @default.
- W4376112612 cites W2891635408 @default.
- W4376112612 cites W2902578750 @default.
- W4376112612 cites W2914571059 @default.
- W4376112612 cites W2921956484 @default.
- W4376112612 cites W2966166439 @default.
- W4376112612 cites W2970797330 @default.
- W4376112612 cites W2972776431 @default.
- W4376112612 cites W2981744955 @default.
- W4376112612 cites W2981757677 @default.
- W4376112612 cites W2982011903 @default.
- W4376112612 cites W2985171343 @default.
- W4376112612 cites W3035096200 @default.
- W4376112612 cites W3046153952 @default.
- W4376112612 cites W3108822686 @default.
- W4376112612 cites W3123698602 @default.
- W4376112612 cites W3132392550 @default.
- W4376112612 cites W3157165533 @default.
- W4376112612 cites W3182450603 @default.
- W4376112612 cites W3217037065 @default.
- W4376112612 doi "https://doi.org/10.1101/2023.05.09.540060" @default.
- W4376112612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37214818" @default.
- W4376112612 hasPublicationYear "2023" @default.
- W4376112612 type Work @default.
- W4376112612 citedByCount "0" @default.
- W4376112612 crossrefType "posted-content" @default.
- W4376112612 hasAuthorship W4376112612A5022375241 @default.