Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376113287> ?p ?o ?g. }
- W4376113287 endingPage "121767" @default.
- W4376113287 startingPage "121767" @default.
- W4376113287 abstract "Over the years, the cavernous nerve (CN) crushing injury rat model has been frequently used for studying post-radical prostatectomy erectile dysfunction (pRP-ED). However, models based on young and healthy rats reportedly exhibit spontaneous recovery of erectile function. Our investigation purpose was to evaluate bilateral CN crushing (BCNC) effects on erectile function besides penile corpus cavernosum pathology in young and old rats and verify whether the BCNC modeling in old rats is more suitable to mimic pRP-ED.Thirty young and old male Sprague-Dawley (SD) rats had been divided into three groups in a random manner: sham-operated group (Sham), CN-injured 2-week group (BCNC-2W), and CN-injured 8-week group (BCNC-8W). At 2 and 8 weeks postoperatively, mean arterial pressure (MAP) along with intracavernosal pressure (ICP) had been determined, respectively. Then, the penis was harvested for histopathological studies.We found that young rats exhibited erectile function spontaneous recovery 8 weeks following BCNC, while old ones failed to recover erectile function. After BCNC, the abundance of nNOS-positive nerve and smooth muscle were reduced, whereas apoptotic levels and collagen I content increased. These pathological modifications gradually resumed over time in young rats, unlike in old rats.Our findings demonstrate that 18-month-old rats do not spontaneously regain erectile function at 8 weeks after BCNC. Therefore, CN-injury ED modeling in 18-month-old rats may be more suitable for studying pRP-ED." @default.
- W4376113287 created "2023-05-12" @default.
- W4376113287 creator A5009385103 @default.
- W4376113287 creator A5029254179 @default.
- W4376113287 creator A5051637669 @default.
- W4376113287 creator A5052890163 @default.
- W4376113287 creator A5053725057 @default.
- W4376113287 creator A5066470725 @default.
- W4376113287 creator A5067940678 @default.
- W4376113287 creator A5071690855 @default.
- W4376113287 date "2023-07-01" @default.
- W4376113287 modified "2023-10-17" @default.
- W4376113287 title "An animal model induced by bilateral cavernous nerve crushing mimics post-radical prostatectomy erectile dysfunction in old rats" @default.
- W4376113287 cites W1556636289 @default.
- W4376113287 cites W1558777104 @default.
- W4376113287 cites W1607554541 @default.
- W4376113287 cites W1869213373 @default.
- W4376113287 cites W1872196862 @default.
- W4376113287 cites W2004897043 @default.
- W4376113287 cites W2008274227 @default.
- W4376113287 cites W2011869643 @default.
- W4376113287 cites W2016448757 @default.
- W4376113287 cites W2017507531 @default.
- W4376113287 cites W2091562888 @default.
- W4376113287 cites W2110091506 @default.
- W4376113287 cites W2120119879 @default.
- W4376113287 cites W2749505362 @default.
- W4376113287 cites W2783895038 @default.
- W4376113287 cites W2808169793 @default.
- W4376113287 cites W2972486511 @default.
- W4376113287 cites W2995690356 @default.
- W4376113287 cites W3014687357 @default.
- W4376113287 cites W3042772274 @default.
- W4376113287 cites W3042819260 @default.
- W4376113287 cites W3097158220 @default.
- W4376113287 cites W3128646645 @default.
- W4376113287 cites W3168569130 @default.
- W4376113287 cites W3204260246 @default.
- W4376113287 cites W3215720640 @default.
- W4376113287 cites W4206040598 @default.
- W4376113287 cites W4210680352 @default.
- W4376113287 cites W4286374228 @default.
- W4376113287 cites W4308741967 @default.
- W4376113287 doi "https://doi.org/10.1016/j.lfs.2023.121767" @default.
- W4376113287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37172816" @default.
- W4376113287 hasPublicationYear "2023" @default.
- W4376113287 type Work @default.
- W4376113287 citedByCount "0" @default.
- W4376113287 crossrefType "journal-article" @default.
- W4376113287 hasAuthorship W4376113287A5009385103 @default.
- W4376113287 hasAuthorship W4376113287A5029254179 @default.
- W4376113287 hasAuthorship W4376113287A5051637669 @default.
- W4376113287 hasAuthorship W4376113287A5052890163 @default.
- W4376113287 hasAuthorship W4376113287A5053725057 @default.
- W4376113287 hasAuthorship W4376113287A5066470725 @default.
- W4376113287 hasAuthorship W4376113287A5067940678 @default.
- W4376113287 hasAuthorship W4376113287A5071690855 @default.
- W4376113287 hasConcept C121608353 @default.
- W4376113287 hasConcept C126322002 @default.
- W4376113287 hasConcept C126894567 @default.
- W4376113287 hasConcept C134018914 @default.
- W4376113287 hasConcept C141071460 @default.
- W4376113287 hasConcept C207886595 @default.
- W4376113287 hasConcept C2775991916 @default.
- W4376113287 hasConcept C2776235491 @default.
- W4376113287 hasConcept C2777786686 @default.
- W4376113287 hasConcept C2779466945 @default.
- W4376113287 hasConcept C2779929075 @default.
- W4376113287 hasConcept C3020768380 @default.
- W4376113287 hasConcept C71924100 @default.
- W4376113287 hasConceptScore W4376113287C121608353 @default.
- W4376113287 hasConceptScore W4376113287C126322002 @default.
- W4376113287 hasConceptScore W4376113287C126894567 @default.
- W4376113287 hasConceptScore W4376113287C134018914 @default.
- W4376113287 hasConceptScore W4376113287C141071460 @default.
- W4376113287 hasConceptScore W4376113287C207886595 @default.
- W4376113287 hasConceptScore W4376113287C2775991916 @default.
- W4376113287 hasConceptScore W4376113287C2776235491 @default.
- W4376113287 hasConceptScore W4376113287C2777786686 @default.
- W4376113287 hasConceptScore W4376113287C2779466945 @default.
- W4376113287 hasConceptScore W4376113287C2779929075 @default.
- W4376113287 hasConceptScore W4376113287C3020768380 @default.
- W4376113287 hasConceptScore W4376113287C71924100 @default.
- W4376113287 hasFunder F4320321001 @default.
- W4376113287 hasFunder F4320322735 @default.
- W4376113287 hasLocation W43761132871 @default.
- W4376113287 hasLocation W43761132872 @default.
- W4376113287 hasOpenAccess W4376113287 @default.
- W4376113287 hasPrimaryLocation W43761132871 @default.
- W4376113287 hasRelatedWork W1981635576 @default.
- W4376113287 hasRelatedWork W1992414199 @default.
- W4376113287 hasRelatedWork W2081791238 @default.
- W4376113287 hasRelatedWork W2107827337 @default.
- W4376113287 hasRelatedWork W2355655723 @default.
- W4376113287 hasRelatedWork W2410316056 @default.
- W4376113287 hasRelatedWork W2530461552 @default.
- W4376113287 hasRelatedWork W2612948534 @default.
- W4376113287 hasRelatedWork W2912438165 @default.