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- W4376115596 endingPage "1353" @default.
- W4376115596 startingPage "1353" @default.
- W4376115596 abstract "Temperature changes and periods of detrimental cold occur frequently for many organisms in their natural habitats. Homeothermic animals have evolved metabolic adaptation strategies to increase mitochondrial-based energy expenditure and heat production, largely relying on fat as a fuel source. Alternatively, certain species are able to repress their metabolism during cold periods and enter a state of decreased physiological activity known as torpor. By contrast, poikilotherms, which are unable to maintain their internal temperature, predominantly increase membrane fluidity to diminish cold-related damage from low-temperature stress. However, alterations of molecular pathways and the regulation of lipid-metabolic reprogramming during cold exposure are poorly understood. Here, we review organismal responses that adjust fat metabolism during detrimental cold stress. Cold-related changes in membranes are detected by membrane-bound sensors, which signal to downstream transcriptional effectors, including nuclear hormone receptors of the PPAR (peroxisome proliferator-activated receptor) subfamily. PPARs control lipid metabolic processes, such as fatty acid desaturation, lipid catabolism and mitochondrial-based thermogenesis. Elucidating the underlying molecular mechanisms of cold adaptation may improve beneficial therapeutic cold treatments and could have important implications for medical applications of hypothermia in humans. This includes treatment strategies for hemorrhagic shock, stroke, obesity and cancer." @default.
- W4376115596 created "2023-05-12" @default.
- W4376115596 creator A5015531017 @default.
- W4376115596 creator A5053004770 @default.
- W4376115596 creator A5064000626 @default.
- W4376115596 date "2023-05-10" @default.
- W4376115596 modified "2023-10-14" @default.
- W4376115596 title "Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold" @default.
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