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- W4376115891 abstract "Abstract Clostridioides difficile , which causes life-threatening diarrheal disease, is considered an urgent threat to healthcare setting worldwide. The current standards of care solely rely on conventional antibiotic treatment, however, there is a risk of promoting recurrent C. difficile infection (rCDI) because of the emergence of antibiotic-resistant strains. Globally, the alarming spread of antibiotic-resistant strains of C. difficile has resulted in a quest for alternative therapeutics. The use of fecal microbiota transplantation (FMT), which involves direct infusion of fecal suspension from a healthy donor into a diseased recipient, has been approved as a highly efficient therapeutic option for patients with rCDI. Bacteriophages or phages are a group of viruses that can infect and destroy bacterial hosts, and are recognized as the dominant viral component of the human gut microbiome. Accumulating data has demonstrated that phages play a vital role in microbial balance of the human gut microbiome. Recently, phage therapy and fecal virome transplantation (FVT) have been introduced as promising alternatives for the treatment of C. difficile - related infections, in particular drug-resistant CDI. Herein, we review the latest updates on C. difficile - specific phages, and phage-mediated treatments, and highlight the current and future prospects of phage therapy in the management of CDI." @default.
- W4376115891 created "2023-05-12" @default.
- W4376115891 creator A5004425214 @default.
- W4376115891 creator A5018739716 @default.
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- W4376115891 creator A5055420813 @default.
- W4376115891 creator A5069476957 @default.
- W4376115891 creator A5072254700 @default.
- W4376115891 date "2023-05-09" @default.
- W4376115891 modified "2023-10-18" @default.
- W4376115891 title "Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives" @default.
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