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• W4376116482 startingPage "115447" @default.
• W4376116482 abstract "The success of inhibitor-based therapeutics is largely constrained by the acquisition of therapeutic resistance, which is partially driven by the undruggable proteome. The emergence of proteolysis targeting chimera (PROTAC) technology, designed for degrading proteins involved in specific biological processes, might provide a novel framework for solving the above constraint. A heterobifunctional PROTAC molecule could structurally connect an E3 ubiquitin ligase ligand with a protein of interest (POI)-binding ligand by chemical linkers. Such technology would result in the degradation of the targeted protein via the ubiquitin-proteasome system (UPS), opening up a novel way of selectively inhibiting undruggable proteins. Herein, we will highlight the advantages of PROTAC technology and summarize the current understanding of the potential mechanisms involved in biotherapeutics, with a particular focus on its application and development where therapeutic benefits over classical small-molecule inhibitors have been achieved. Finally, we discuss how this technology can contribute to developing biotherapeutic drugs, such as antivirals against infectious diseases, for use in clinical practices." @default.
• W4376116482 created "2023-05-12" @default.
• W4376116482 creator A5004451173 @default.
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• W4376116482 creator A5056106013 @default.
• W4376116482 creator A5063613049 @default.
• W4376116482 creator A5087859400 @default.
• W4376116482 date "2023-09-01" @default.
• W4376116482 modified "2023-10-16" @default.
• W4376116482 title "Proteolysis-targeting chimeras in biotherapeutics: Current trends and future applications" @default.
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