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- W4376116877 abstract "Four previously undescribed highly oxygenated diterpenoids (1–4), zeylleucapenoids A–D, characterized by halimane and labdane skeletons, were isolated from the aerial parts of Leucas zeylanica. Their structures were elucidated primarily by NMR experiments. The absolute configuration of 1 was established by theoretical ECD calculations and X-ray crystallographic analysis, whereas those for 2−4 were assigned by theoretical ORD calculations. Zeylleucapenoid D (4), with an IC50 value of 38.45 μM in RAW264.7 macrophages and nontoxic activity for zebrafish embryo, and obviously inhibited pro-inflammatory cytokines TNF-α and IL-6 in a dose-dependent manner. Compound 4 inhibited of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, molecular docking analysis indicated the possible mechanism of action for 4 may be bind to targets by hydrogen- and hydrophobic- bond interactions." @default.
- W4376116877 created "2023-05-12" @default.
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- W4376116877 date "2023-05-09" @default.
- W4376116877 modified "2023-09-29" @default.
- W4376116877 title "Zeylleucapenoids A-D, Highly Oxygenated Diterpenoids with Anti-inflammatory Activity from <em><i>Leucas zeylanica</i></em>" @default.
- W4376116877 doi "https://doi.org/10.20944/preprints202305.0651.v1" @default.
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