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- W4376118383 abstract "Unnatural amino acids (UAAs) have broad applications in pharmaceutical sciences and biological studies. Current synthetic methods for UAAs mainly rely on asymmetric catalysis and often require several steps. There is a lack of direct and simple methods. To address this challenge, we designed the LADA (labeling-activation-desulfurization-addition) strategy: selective labeling and activation of cysteine residues, the photocatalytic desulfurization and the subsequent radical addition to alkenes. Although composed of two steps, it's one-pot synthesis and has advantages such as high functional group tolerance, biocompatible reaction condition, and retained stereochemistry. This highly efficient strategy was successfully applied in the direct synthesis of unnatural amino acids and modifications of peptides with more than 50 examples." @default.
- W4376118383 created "2023-05-12" @default.
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- W4376118383 date "2023-05-01" @default.
- W4376118383 modified "2023-10-18" @default.
- W4376118383 title "Direct synthesis of unnatural amino acids and modifications of peptides via LADA strategy" @default.
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- W4376118383 doi "https://doi.org/10.1016/j.cclet.2023.108553" @default.
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