Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376121346> ?p ?o ?g. }
- W4376121346 abstract "Abstract Purpose Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of autoantibodies in human sera of participants with different stages of AMD in a large population-based, observational cohort study in Germany. Methods The Gutenberg Health Study (GHS) is a population-based, observational cohort study in Germany, including 15,010 participants aged between 35 and 74. Amongst others, non-mydriatic fundus photography (Visucam PRO NM™, Carl Zeiss Meditec AG, Jena, Germany) was performed. Fundus images of the first 5000 participants were graded based on the Rotterdam Eye Study classification. Sera of participants with AMD ( n =541) and sera of age-matched participants without AMD ( n =490) were analyzed by antigen-microarrays. Besides descriptive statistics, autoantibody-levels were compared by Mann-Whitney-U test and the associations of level of autoantibodies with AMD were calculated by logistic regression analysis. Likewise, possible associations of the autoantibodies and both clinical and laboratory parameters on AMD subjects were analyzed. Results Autoantibodies against transferrin ( p <0.001) were significantly downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only compared to Controls. Mitogen-activated protein kinase 3 ( p =0.041), glutathione peroxidase 4 ( p =0.048), clusterin ( p =0.045), lysozyme ( p =0.19), protein kinase C substrate 80K-H ( p =0.02), heat shock 70 kDa protein 1A ( p =0.04) and insulin ( p =0.018) show a trend between Control and participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only. Conclusions This study contributes to a growing knowledge of autoantibodies in association with different AMD stages compared to controls in the context of a large population-based study in Germany. Especially autoantibodies against inflammatory proteins were downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only." @default.
- W4376121346 created "2023-05-12" @default.
- W4376121346 creator A5003450562 @default.
- W4376121346 creator A5035254382 @default.
- W4376121346 creator A5040088384 @default.
- W4376121346 creator A5043996746 @default.
- W4376121346 creator A5048016826 @default.
- W4376121346 creator A5050209320 @default.
- W4376121346 creator A5054487026 @default.
- W4376121346 creator A5064102902 @default.
- W4376121346 creator A5071283067 @default.
- W4376121346 creator A5075174977 @default.
- W4376121346 creator A5079455074 @default.
- W4376121346 creator A5082605838 @default.
- W4376121346 date "2023-05-09" @default.
- W4376121346 modified "2023-10-03" @default.
- W4376121346 title "Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS)" @default.
- W4376121346 cites W1438640379 @default.
- W4376121346 cites W1523693806 @default.
- W4376121346 cites W1927715613 @default.
- W4376121346 cites W1964332100 @default.
- W4376121346 cites W1967996072 @default.
- W4376121346 cites W1968298081 @default.
- W4376121346 cites W1969085888 @default.
- W4376121346 cites W1972424130 @default.
- W4376121346 cites W1992859141 @default.
- W4376121346 cites W1992898823 @default.
- W4376121346 cites W1997312920 @default.
- W4376121346 cites W2000524781 @default.
- W4376121346 cites W2001342818 @default.
- W4376121346 cites W2005487633 @default.
- W4376121346 cites W2014223882 @default.
- W4376121346 cites W2014881030 @default.
- W4376121346 cites W2016996903 @default.
- W4376121346 cites W2019362945 @default.
- W4376121346 cites W2033801464 @default.
- W4376121346 cites W2041557956 @default.
- W4376121346 cites W2044895376 @default.
- W4376121346 cites W2046306972 @default.
- W4376121346 cites W2068001921 @default.
- W4376121346 cites W2071889856 @default.
- W4376121346 cites W2079406256 @default.
- W4376121346 cites W2081741515 @default.
- W4376121346 cites W2091832434 @default.
- W4376121346 cites W2092460143 @default.
- W4376121346 cites W2094062676 @default.
- W4376121346 cites W2094499894 @default.
- W4376121346 cites W2096128707 @default.
- W4376121346 cites W2099645441 @default.
- W4376121346 cites W2117524604 @default.
- W4376121346 cites W2125232760 @default.
- W4376121346 cites W2149506916 @default.
- W4376121346 cites W2157100733 @default.
- W4376121346 cites W2158770960 @default.
- W4376121346 cites W2170780440 @default.
- W4376121346 cites W2322047850 @default.
- W4376121346 cites W2366803898 @default.
- W4376121346 cites W2400001653 @default.
- W4376121346 cites W2468578267 @default.
- W4376121346 cites W2580514836 @default.
- W4376121346 cites W2738996050 @default.
- W4376121346 cites W2746096415 @default.
- W4376121346 cites W2787453495 @default.
- W4376121346 cites W4247214019 @default.
- W4376121346 cites W9727340 @default.
- W4376121346 doi "https://doi.org/10.1007/s00417-023-06085-2" @default.
- W4376121346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37160502" @default.
- W4376121346 hasPublicationYear "2023" @default.
- W4376121346 type Work @default.
- W4376121346 citedByCount "0" @default.
- W4376121346 crossrefType "journal-article" @default.
- W4376121346 hasAuthorship W4376121346A5003450562 @default.
- W4376121346 hasAuthorship W4376121346A5035254382 @default.
- W4376121346 hasAuthorship W4376121346A5040088384 @default.
- W4376121346 hasAuthorship W4376121346A5043996746 @default.
- W4376121346 hasAuthorship W4376121346A5048016826 @default.
- W4376121346 hasAuthorship W4376121346A5050209320 @default.
- W4376121346 hasAuthorship W4376121346A5054487026 @default.
- W4376121346 hasAuthorship W4376121346A5064102902 @default.
- W4376121346 hasAuthorship W4376121346A5071283067 @default.
- W4376121346 hasAuthorship W4376121346A5075174977 @default.
- W4376121346 hasAuthorship W4376121346A5079455074 @default.
- W4376121346 hasAuthorship W4376121346A5082605838 @default.
- W4376121346 hasBestOaLocation W43761213461 @default.
- W4376121346 hasConcept C118487528 @default.
- W4376121346 hasConcept C126322002 @default.
- W4376121346 hasConcept C156957248 @default.
- W4376121346 hasConcept C159654299 @default.
- W4376121346 hasConcept C163764329 @default.
- W4376121346 hasConcept C203014093 @default.
- W4376121346 hasConcept C2776403814 @default.
- W4376121346 hasConcept C2776474195 @default.
- W4376121346 hasConcept C2779093074 @default.
- W4376121346 hasConcept C2780248432 @default.
- W4376121346 hasConcept C2780827179 @default.
- W4376121346 hasConcept C2908647359 @default.
- W4376121346 hasConcept C71924100 @default.
- W4376121346 hasConcept C72563966 @default.
- W4376121346 hasConcept C77350462 @default.
- W4376121346 hasConcept C99454951 @default.