FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376121421> ?p ?o ?g. }

• W4376121421 abstract "Abstract To maintain both mitochondrial quality and quantity, cells selectively remove damaged or excessive mitochondria through mitophagy, which is a specialised form of autophagy. Mitophagy is induced in response to diverse conditions, including hypoxia, cellular differentiation and mitochondrial damage. However, the mechanisms that govern the removal of specific dysfunctional mitochondria under steady‐state conditions to fine‐tune mitochondrial content are not well understood. Here, we report that SCF FBXL4 , an SKP1/CUL1/F‐box protein ubiquitin ligase complex, localises to the mitochondrial outer membrane in unstressed cells and mediates the constitutive ubiquitylation and degradation of the mitophagy receptors NIX and BNIP3 to suppress basal levels of mitophagy. We demonstrate that the pathogenic variants of FBXL4 that cause encephalopathic mtDNA depletion syndrome (MTDPS13) do not efficiently interact with the core SCF ubiquitin ligase machinery or mediate the degradation of NIX and BNIP3. Thus, we reveal a molecular mechanism whereby FBXL4 actively suppresses mitophagy by preventing NIX and BNIP3 accumulation. We propose that the dysregulation of NIX and BNIP3 turnover causes excessive basal mitophagy in FBXL4‐associated mtDNA depletion syndrome." @default.
• W4376121421 created "2023-05-12" @default.
• W4376121421 creator A5000747636 @default.
• W4376121421 creator A5010173449 @default.
• W4376121421 creator A5014893281 @default.
• W4376121421 creator A5018057407 @default.
• W4376121421 creator A5021945375 @default.
• W4376121421 creator A5022580770 @default.
• W4376121421 creator A5029211283 @default.
• W4376121421 creator A5029816112 @default.
• W4376121421 creator A5033262019 @default.
• W4376121421 creator A5034919044 @default.
• W4376121421 creator A5050123515 @default.
• W4376121421 creator A5050400735 @default.
• W4376121421 creator A5050688071 @default.
• W4376121421 creator A5061877082 @default.
• W4376121421 creator A5063634904 @default.
• W4376121421 creator A5064926521 @default.
• W4376121421 creator A5066459919 @default.
• W4376121421 date "2023-05-10" @default.
• W4376121421 modified "2023-10-15" @default.
• W4376121421 title "<scp>FBXL4</scp> suppresses mitophagy by restricting the accumulation of <scp>NIX</scp> and <scp>BNIP3</scp> mitophagy receptors" @default.
• W4376121421 cites W1749022239 @default.
• W4376121421 cites W1965827991 @default.
• W4376121421 cites W1968843321 @default.
• W4376121421 cites W1991533918 @default.
• W4376121421 cites W2012967220 @default.
• W4376121421 cites W2038834667 @default.
• W4376121421 cites W2040031153 @default.
• W4376121421 cites W2044829505 @default.
• W4376121421 cites W2045012604 @default.
• W4376121421 cites W2047242847 @default.
• W4376121421 cites W2048611034 @default.
• W4376121421 cites W2050723187 @default.
• W4376121421 cites W2062830884 @default.
• W4376121421 cites W2068700852 @default.
• W4376121421 cites W2070098827 @default.
• W4376121421 cites W2076194625 @default.
• W4376121421 cites W2081051270 @default.
• W4376121421 cites W2089612936 @default.
• W4376121421 cites W2103230459 @default.
• W4376121421 cites W2118094114 @default.
• W4376121421 cites W2122556106 @default.
• W4376121421 cites W2127440157 @default.
• W4376121421 cites W2144625075 @default.
• W4376121421 cites W2144670533 @default.
• W4376121421 cites W2146122852 @default.
• W4376121421 cites W2155015733 @default.
• W4376121421 cites W2158535498 @default.
• W4376121421 cites W2160664949 @default.
• W4376121421 cites W2164945122 @default.
• W4376121421 cites W2593462505 @default.
• W4376121421 cites W2605825818 @default.
• W4376121421 cites W2610895525 @default.
• W4376121421 cites W2735816534 @default.
• W4376121421 cites W2783409125 @default.
• W4376121421 cites W2787965853 @default.
• W4376121421 cites W2788644497 @default.
• W4376121421 cites W2913650647 @default.
• W4376121421 cites W2949223833 @default.
• W4376121421 cites W2951149542 @default.
• W4376121421 cites W2969847823 @default.
• W4376121421 cites W3011835552 @default.
• W4376121421 cites W3016185846 @default.
• W4376121421 cites W3033262131 @default.
• W4376121421 cites W3121008513 @default.
• W4376121421 cites W3127992352 @default.
• W4376121421 cites W3150184953 @default.
• W4376121421 cites W3156007823 @default.
• W4376121421 cites W3161391707 @default.
• W4376121421 cites W3177828909 @default.
• W4376121421 cites W4205735374 @default.
• W4376121421 cites W4281790889 @default.
• W4376121421 cites W4304141608 @default.
• W4376121421 cites W4376121421 @default.
• W4376121421 doi "https://doi.org/10.15252/embj.2022112767" @default.
• W4376121421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37161784" @default.
• W4376121421 hasPublicationYear "2023" @default.
• W4376121421 type Work @default.
• W4376121421 citedByCount "6" @default.
• W4376121421 countsByYear W43761214212023 @default.
• W4376121421 crossrefType "journal-article" @default.
• W4376121421 hasAuthorship W4376121421A5000747636 @default.
• W4376121421 hasAuthorship W4376121421A5010173449 @default.
• W4376121421 hasAuthorship W4376121421A5014893281 @default.
• W4376121421 hasAuthorship W4376121421A5018057407 @default.
• W4376121421 hasAuthorship W4376121421A5021945375 @default.
• W4376121421 hasAuthorship W4376121421A5022580770 @default.
• W4376121421 hasAuthorship W4376121421A5029211283 @default.
• W4376121421 hasAuthorship W4376121421A5029816112 @default.
• W4376121421 hasAuthorship W4376121421A5033262019 @default.
• W4376121421 hasAuthorship W4376121421A5034919044 @default.
• W4376121421 hasAuthorship W4376121421A5050123515 @default.
• W4376121421 hasAuthorship W4376121421A5050400735 @default.
• W4376121421 hasAuthorship W4376121421A5050688071 @default.
• W4376121421 hasAuthorship W4376121421A5061877082 @default.
• W4376121421 hasAuthorship W4376121421A5063634904 @default.
• W4376121421 hasAuthorship W4376121421A5064926521 @default.
• W4376121421 hasAuthorship W4376121421A5066459919 @default.
• W4376121421 hasBestOaLocation W43761214211 @default.

• next