FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376121441> ?p ?o ?g. }

• W4376121441 abstract "Abstract Background Statin therapy has shown pleiotropic effects affecting both mitochondrial function and inflammatory status. However, few studies have investigated the concurrent effects of statin exposure on mitochondrial function and inflammatory status in human subcutaneous white adipose tissue. Objectives In a cross-sectional study, we investigated the effects of simvastatin on mitochondrial function and inflammatory status in subcutaneous white adipose tissue of 55 human participants: 38 patients (19 females/19 males) in primary prevention with simvastatin (&gt; 40 mg/d, &gt; 3 mo) and 17 controls (9 females/8 males) with elevated plasma cholesterol. The 2 groups were matched on age, body mass index, and maximal oxygen consumption. Methods Anthropometrics and fasting biochemical characteristics were measured. Mitochondrial respiratory capacity was assessed in white adipose tissue by high-resolution respirometry. Subcutaneous white adipose tissue expression of the inflammatory markers IL-6, chemokine (C-C motif) ligand 2 (CCL2), CCL-5, tumor necrosis factor-α, IL-10, and IL-4 was analyzed by quantitative PCR. Results Simvastatin-treated patients showed lower plasma cholesterol (P &lt; .0001), low-density lipoprotein (P &lt; .0001), and triglyceride levels (P = .0116) than controls. Simvastatin-treated patients had a lower oxidative phosphorylation capacity of mitochondrial complex II (P = .0001 when normalized to wet weight, P &lt; .0001 when normalized to citrate synthase activity [intrinsic]), and a lower intrinsic mitochondrial electron transport system capacity (P = .0004). Simvastatin-treated patients showed higher IL-6 expression than controls (P = .0202). Conclusion Simvastatin treatment was linked to mitochondrial respiratory capacity in human subcutaneous white adipose tissue, but no clear link was found between statin exposure, respiratory changes, and inflammatory status of adipose tissue." @default.
• W4376121441 created "2023-05-12" @default.
• W4376121441 creator A5005445641 @default.
• W4376121441 creator A5016008611 @default.
• W4376121441 creator A5044538234 @default.
• W4376121441 creator A5054145357 @default.
• W4376121441 creator A5066898531 @default.
• W4376121441 creator A5076988041 @default.
• W4376121441 creator A5077907453 @default.
• W4376121441 creator A5087815611 @default.
• W4376121441 date "2023-05-10" @default.
• W4376121441 modified "2023-10-07" @default.
• W4376121441 title "Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue" @default.
• W4376121441 cites W1598869449 @default.
• W4376121441 cites W1607804102 @default.
• W4376121441 cites W1608849851 @default.
• W4376121441 cites W173808884 @default.
• W4376121441 cites W1929626127 @default.
• W4376121441 cites W1985595789 @default.
• W4376121441 cites W1986949841 @default.
• W4376121441 cites W2002346836 @default.
• W4376121441 cites W2016678257 @default.
• W4376121441 cites W2023746393 @default.
• W4376121441 cites W2025731229 @default.
• W4376121441 cites W2093366966 @default.
• W4376121441 cites W2095834322 @default.
• W4376121441 cites W2101243667 @default.
• W4376121441 cites W2102743559 @default.
• W4376121441 cites W2106860177 @default.
• W4376121441 cites W2109145286 @default.
• W4376121441 cites W2109828316 @default.
• W4376121441 cites W2123923369 @default.
• W4376121441 cites W2137275605 @default.
• W4376121441 cites W2138175677 @default.
• W4376121441 cites W2142484824 @default.
• W4376121441 cites W2144728950 @default.
• W4376121441 cites W2163414121 @default.
• W4376121441 cites W2216733834 @default.
• W4376121441 cites W2321557729 @default.
• W4376121441 cites W2405624971 @default.
• W4376121441 cites W2776306725 @default.
• W4376121441 cites W2782157565 @default.
• W4376121441 cites W2801335865 @default.
• W4376121441 cites W2890239301 @default.
• W4376121441 cites W2897209253 @default.
• W4376121441 cites W2898877757 @default.
• W4376121441 cites W2902794984 @default.
• W4376121441 cites W2935850363 @default.
• W4376121441 cites W3092621275 @default.
• W4376121441 cites W3122339970 @default.
• W4376121441 cites W3195626455 @default.
• W4376121441 doi "https://doi.org/10.1210/clinem/dgad259" @default.
• W4376121441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37161534" @default.
• W4376121441 hasPublicationYear "2023" @default.
• W4376121441 type Work @default.
• W4376121441 citedByCount "0" @default.
• W4376121441 crossrefType "journal-article" @default.
• W4376121441 hasAuthorship W4376121441A5005445641 @default.
• W4376121441 hasAuthorship W4376121441A5016008611 @default.
• W4376121441 hasAuthorship W4376121441A5044538234 @default.
• W4376121441 hasAuthorship W4376121441A5054145357 @default.
• W4376121441 hasAuthorship W4376121441A5066898531 @default.
• W4376121441 hasAuthorship W4376121441A5076988041 @default.
• W4376121441 hasAuthorship W4376121441A5077907453 @default.
• W4376121441 hasAuthorship W4376121441A5087815611 @default.
• W4376121441 hasBestOaLocation W43761214411 @default.
• W4376121441 hasConcept C111133373 @default.
• W4376121441 hasConcept C126322002 @default.
• W4376121441 hasConcept C134018914 @default.
• W4376121441 hasConcept C151955695 @default.
• W4376121441 hasConcept C171089720 @default.
• W4376121441 hasConcept C181199279 @default.
• W4376121441 hasConcept C185592680 @default.
• W4376121441 hasConcept C2776329913 @default.
• W4376121441 hasConcept C2778163477 @default.
• W4376121441 hasConcept C2778913445 @default.
• W4376121441 hasConcept C28859421 @default.
• W4376121441 hasConcept C3020761558 @default.
• W4376121441 hasConcept C55493867 @default.
• W4376121441 hasConcept C71924100 @default.
• W4376121441 hasConceptScore W4376121441C111133373 @default.
• W4376121441 hasConceptScore W4376121441C126322002 @default.
• W4376121441 hasConceptScore W4376121441C134018914 @default.
• W4376121441 hasConceptScore W4376121441C151955695 @default.
• W4376121441 hasConceptScore W4376121441C171089720 @default.
• W4376121441 hasConceptScore W4376121441C181199279 @default.
• W4376121441 hasConceptScore W4376121441C185592680 @default.
• W4376121441 hasConceptScore W4376121441C2776329913 @default.
• W4376121441 hasConceptScore W4376121441C2778163477 @default.
• W4376121441 hasConceptScore W4376121441C2778913445 @default.
• W4376121441 hasConceptScore W4376121441C28859421 @default.
• W4376121441 hasConceptScore W4376121441C3020761558 @default.
• W4376121441 hasConceptScore W4376121441C55493867 @default.
• W4376121441 hasConceptScore W4376121441C71924100 @default.
• W4376121441 hasLocation W43761214411 @default.
• W4376121441 hasLocation W43761214412 @default.
• W4376121441 hasOpenAccess W4376121441 @default.
• W4376121441 hasPrimaryLocation W43761214411 @default.
• W4376121441 hasRelatedWork W1951732046 @default.
• W4376121441 hasRelatedWork W1957106181 @default.

• next