Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376121648> ?p ?o ?g. }
- W4376121648 abstract "Total thymectomy in addition to medical treatment is an accepted standard therapy for myasthenia gravis (MG). Patients with severe generalized MG present life-threatening events, poor prognosis and higher risk of postoperative myasthenic crisis. The aim of our study is to investigate neurological and surgical results in patients with Myasthenia Gravis Foundation of America (MGFA) class IV and V MG following thymectomy.Data on 76 MG patients with preoperative MGFA classes IV and V who underwent thymectomy were retrospectively collected. Primary end points included short-term surgical outcomes and long-term neurological results including the achievement of complete stable remission and any improvement as defined by MGFA Post-Intervention Status criteria.There were 27 (35.5%) males and 49 (64.5%) females; 53 (69.7%) were classified as MGFA class IV and 23 (30.3%) as class V. Thymectomy was performed through sternotomy in 25 (32.9%) patients, Video-assisted thoracic surgery (VATS) in 5 (6.6%) and Robot-assisted thoracic surgery (RATS) in 46 (60.5%). The median operative time was 120 (interquartile range: 95; 148) min. In-hospital mortality was observed in 1 (1.3%) patient and postoperative complications in 14 (18.4%) patients. The median postoperative hospital stay was 4 (interquartile range: 3; 6) days. Pathological examination revealed 31 (40.8%) thymic hyperplasia/other benign and 45 (59.2%) thymomas. Cumulative complete stable remission and improvement probabilities were 20.6% and 83.7% at 5 years and 66.9% and 97.6% at 10 years, respectively. A significant improvement rate was found in patients with age at the time of thymectomy of ≤50 years (P = 0.0236), MGFA class V (P = 0.0154) and acetylcholine receptor antibodies positivity (P = 0.0152).Thymectomy in patients with severe MG yields good perioperative outcomes and satisfactory long-term neurological improvement, especially for patients younger than 50 years, with MGFA class V and anti-AChR+ MG." @default.
- W4376121648 created "2023-05-12" @default.
- W4376121648 creator A5000883389 @default.
- W4376121648 creator A5007236447 @default.
- W4376121648 creator A5014969758 @default.
- W4376121648 creator A5018541312 @default.
- W4376121648 creator A5025434502 @default.
- W4376121648 creator A5027115864 @default.
- W4376121648 creator A5033655563 @default.
- W4376121648 creator A5036297830 @default.
- W4376121648 creator A5039132108 @default.
- W4376121648 creator A5044171254 @default.
- W4376121648 creator A5057113727 @default.
- W4376121648 creator A5057287138 @default.
- W4376121648 creator A5068616337 @default.
- W4376121648 creator A5069406567 @default.
- W4376121648 creator A5080857549 @default.
- W4376121648 creator A5083762202 @default.
- W4376121648 creator A5091162926 @default.
- W4376121648 date "2023-05-01" @default.
- W4376121648 modified "2023-10-18" @default.
- W4376121648 title "Thymectomy in severe (Myasthenia Gravis Foundation of America classes IV–V) generalized myasthenia gravis: is the game really worth the candle?" @default.
- W4376121648 cites W1602245959 @default.
- W4376121648 cites W1976150248 @default.
- W4376121648 cites W1995289926 @default.
- W4376121648 cites W1997897987 @default.
- W4376121648 cites W2038981426 @default.
- W4376121648 cites W2047220739 @default.
- W4376121648 cites W2057621331 @default.
- W4376121648 cites W2066239289 @default.
- W4376121648 cites W2068799176 @default.
- W4376121648 cites W2106045389 @default.
- W4376121648 cites W2111867402 @default.
- W4376121648 cites W2129925362 @default.
- W4376121648 cites W2131437090 @default.
- W4376121648 cites W2158660362 @default.
- W4376121648 cites W2338132066 @default.
- W4376121648 cites W2461303519 @default.
- W4376121648 cites W2473220287 @default.
- W4376121648 cites W2475786228 @default.
- W4376121648 cites W2548440040 @default.
- W4376121648 cites W2755925910 @default.
- W4376121648 cites W2765268515 @default.
- W4376121648 cites W2883745528 @default.
- W4376121648 cites W2922490577 @default.
- W4376121648 cites W2995488591 @default.
- W4376121648 cites W3093840696 @default.
- W4376121648 cites W3097231984 @default.
- W4376121648 cites W3116594146 @default.
- W4376121648 cites W3128196261 @default.
- W4376121648 doi "https://doi.org/10.1093/ejcts/ezad179" @default.
- W4376121648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37162377" @default.
- W4376121648 hasPublicationYear "2023" @default.
- W4376121648 type Work @default.
- W4376121648 citedByCount "0" @default.
- W4376121648 crossrefType "journal-article" @default.
- W4376121648 hasAuthorship W4376121648A5000883389 @default.
- W4376121648 hasAuthorship W4376121648A5007236447 @default.
- W4376121648 hasAuthorship W4376121648A5014969758 @default.
- W4376121648 hasAuthorship W4376121648A5018541312 @default.
- W4376121648 hasAuthorship W4376121648A5025434502 @default.
- W4376121648 hasAuthorship W4376121648A5027115864 @default.
- W4376121648 hasAuthorship W4376121648A5033655563 @default.
- W4376121648 hasAuthorship W4376121648A5036297830 @default.
- W4376121648 hasAuthorship W4376121648A5039132108 @default.
- W4376121648 hasAuthorship W4376121648A5044171254 @default.
- W4376121648 hasAuthorship W4376121648A5057113727 @default.
- W4376121648 hasAuthorship W4376121648A5057287138 @default.
- W4376121648 hasAuthorship W4376121648A5068616337 @default.
- W4376121648 hasAuthorship W4376121648A5069406567 @default.
- W4376121648 hasAuthorship W4376121648A5080857549 @default.
- W4376121648 hasAuthorship W4376121648A5083762202 @default.
- W4376121648 hasAuthorship W4376121648A5091162926 @default.
- W4376121648 hasConcept C119060515 @default.
- W4376121648 hasConcept C126322002 @default.
- W4376121648 hasConcept C141071460 @default.
- W4376121648 hasConcept C187212893 @default.
- W4376121648 hasConcept C2778105408 @default.
- W4376121648 hasConcept C2779615886 @default.
- W4376121648 hasConcept C71924100 @default.
- W4376121648 hasConceptScore W4376121648C119060515 @default.
- W4376121648 hasConceptScore W4376121648C126322002 @default.
- W4376121648 hasConceptScore W4376121648C141071460 @default.
- W4376121648 hasConceptScore W4376121648C187212893 @default.
- W4376121648 hasConceptScore W4376121648C2778105408 @default.
- W4376121648 hasConceptScore W4376121648C2779615886 @default.
- W4376121648 hasConceptScore W4376121648C71924100 @default.
- W4376121648 hasIssue "5" @default.
- W4376121648 hasLocation W43761216481 @default.
- W4376121648 hasLocation W43761216482 @default.
- W4376121648 hasOpenAccess W4376121648 @default.
- W4376121648 hasPrimaryLocation W43761216481 @default.
- W4376121648 hasRelatedWork W2017670452 @default.
- W4376121648 hasRelatedWork W2411864590 @default.
- W4376121648 hasRelatedWork W2492545249 @default.
- W4376121648 hasRelatedWork W26461681 @default.
- W4376121648 hasRelatedWork W3091215059 @default.
- W4376121648 hasRelatedWork W3127801379 @default.
- W4376121648 hasRelatedWork W4288045987 @default.
- W4376121648 hasRelatedWork W4293178097 @default.