Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376125871> ?p ?o ?g. }
- W4376125871 abstract "Abstract Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. Sulforaphane (SFN) has been shown to have anti-inflammatory and antioxidant properties. In this study, we investigated the effects of SFN on a mouse model of psoriasis induced by imiquimod (IMQ) and its underlying molecular mechanism. Mice treated with SFN showed significant improvement in psoriatic symptoms, including reduced erythema, scales, and cutaneous thickness. Histopathological analysis and immunohistochemical staining revealed decreased expression of K16, K17, and Ki67 in SFN-treated mice, indicating reduced abnormal differentiation of keratinocytes and cutaneous inflammation. SFN treatment also reduced the activation of STAT3 and NF-κB pathways and downregulated pro-inflammatory cytokines IL-1β, IL-6, and CCL2. In vitro experiments using HaCaT cells demonstrated that SFN inhibited IL-22 and TNF-α-induced activation of inflammatory pathways and keratinocyte proliferation. Network pharmacology analysis suggested that the KEAP1-NRF2 pathway might be involved in the protective effects of SFN on psoriasis. We observed reduced NRF2 expression in human psoriatic lesions, and subsequent experiments showed that SFN activated KEAP1-NRF2 pathway in vivo and in vitro. Importantly, Nrf2-deficient mice exhibited aggravated psoriasis-like symptoms and reduced response to SFN treatment. Our findings indicate that SFN ameliorates psoriasis symptoms and inflammation through the KEAP1-NRF2 pathway, suggesting a potential therapeutic role for SFN in the treatment of psoriasis." @default.
- W4376125871 created "2023-05-12" @default.
- W4376125871 creator A5001507891 @default.
- W4376125871 creator A5004945001 @default.
- W4376125871 creator A5024200175 @default.
- W4376125871 creator A5027475930 @default.
- W4376125871 creator A5029569812 @default.
- W4376125871 creator A5031927937 @default.
- W4376125871 creator A5035122223 @default.
- W4376125871 creator A5041801320 @default.
- W4376125871 creator A5045545412 @default.
- W4376125871 creator A5067384995 @default.
- W4376125871 creator A5072646701 @default.
- W4376125871 creator A5073963878 @default.
- W4376125871 creator A5087261449 @default.
- W4376125871 creator A5089499746 @default.
- W4376125871 date "2023-05-11" @default.
- W4376125871 modified "2023-09-28" @default.
- W4376125871 title "Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling" @default.
- W4376125871 cites W1987429998 @default.
- W4376125871 cites W2007771944 @default.
- W4376125871 cites W2014732115 @default.
- W4376125871 cites W2032222821 @default.
- W4376125871 cites W2045065875 @default.
- W4376125871 cites W2052720016 @default.
- W4376125871 cites W2056349938 @default.
- W4376125871 cites W2057304280 @default.
- W4376125871 cites W2148878571 @default.
- W4376125871 cites W2160905744 @default.
- W4376125871 cites W2165956966 @default.
- W4376125871 cites W2472642463 @default.
- W4376125871 cites W2753995352 @default.
- W4376125871 cites W2754373048 @default.
- W4376125871 cites W2754930357 @default.
- W4376125871 cites W2776126594 @default.
- W4376125871 cites W2786229868 @default.
- W4376125871 cites W2797770630 @default.
- W4376125871 cites W2803494028 @default.
- W4376125871 cites W2886850546 @default.
- W4376125871 cites W2923436228 @default.
- W4376125871 cites W2946104037 @default.
- W4376125871 cites W2967476539 @default.
- W4376125871 cites W3001433831 @default.
- W4376125871 cites W3012392756 @default.
- W4376125871 cites W3015784228 @default.
- W4376125871 cites W3027850110 @default.
- W4376125871 cites W3081254755 @default.
- W4376125871 cites W3106857781 @default.
- W4376125871 cites W3137878085 @default.
- W4376125871 cites W3173609248 @default.
- W4376125871 cites W3196471353 @default.
- W4376125871 cites W3201424131 @default.
- W4376125871 cites W4206739528 @default.
- W4376125871 cites W4224250805 @default.
- W4376125871 cites W4229023240 @default.
- W4376125871 cites W962657022 @default.
- W4376125871 doi "https://doi.org/10.21203/rs.3.rs-2800948/v1" @default.
- W4376125871 hasPublicationYear "2023" @default.
- W4376125871 type Work @default.
- W4376125871 citedByCount "0" @default.
- W4376125871 crossrefType "posted-content" @default.
- W4376125871 hasAuthorship W4376125871A5001507891 @default.
- W4376125871 hasAuthorship W4376125871A5004945001 @default.
- W4376125871 hasAuthorship W4376125871A5024200175 @default.
- W4376125871 hasAuthorship W4376125871A5027475930 @default.
- W4376125871 hasAuthorship W4376125871A5029569812 @default.
- W4376125871 hasAuthorship W4376125871A5031927937 @default.
- W4376125871 hasAuthorship W4376125871A5035122223 @default.
- W4376125871 hasAuthorship W4376125871A5041801320 @default.
- W4376125871 hasAuthorship W4376125871A5045545412 @default.
- W4376125871 hasAuthorship W4376125871A5067384995 @default.
- W4376125871 hasAuthorship W4376125871A5072646701 @default.
- W4376125871 hasAuthorship W4376125871A5073963878 @default.
- W4376125871 hasAuthorship W4376125871A5087261449 @default.
- W4376125871 hasAuthorship W4376125871A5089499746 @default.
- W4376125871 hasBestOaLocation W43761258711 @default.
- W4376125871 hasConcept C104317684 @default.
- W4376125871 hasConcept C118995209 @default.
- W4376125871 hasConcept C150903083 @default.
- W4376125871 hasConcept C17991360 @default.
- W4376125871 hasConcept C185592680 @default.
- W4376125871 hasConcept C202751555 @default.
- W4376125871 hasConcept C203014093 @default.
- W4376125871 hasConcept C207001950 @default.
- W4376125871 hasConcept C2776529522 @default.
- W4376125871 hasConcept C2776914184 @default.
- W4376125871 hasConcept C2778923194 @default.
- W4376125871 hasConcept C2780564577 @default.
- W4376125871 hasConcept C2780841255 @default.
- W4376125871 hasConcept C502942594 @default.
- W4376125871 hasConcept C55493867 @default.
- W4376125871 hasConcept C62478195 @default.
- W4376125871 hasConcept C71924100 @default.
- W4376125871 hasConcept C86339819 @default.
- W4376125871 hasConcept C86803240 @default.
- W4376125871 hasConcept C98274493 @default.
- W4376125871 hasConceptScore W4376125871C104317684 @default.
- W4376125871 hasConceptScore W4376125871C118995209 @default.
- W4376125871 hasConceptScore W4376125871C150903083 @default.
- W4376125871 hasConceptScore W4376125871C17991360 @default.