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• W4376125992 abstract "Abstract Background: To develop and validate radiomic models for prediction of tumor response to neoadjuvant therapy (NAT) in patients with locally advanced rectal cancer (LARC) using both pre-NAT and post-NAT multiparameter magnetic resonance imaging (mpMRI). Methods: In this multicenter study, a total of 563 patients were included from two independent centers. 453 patients from center 1 were split into training and testing cohorts, the remaining 110 from center 2 served as an external validation cohort. Pre-NAT and post-NAT mpMRI was collected for feature extraction. The radiomic models were constructed using machine learning from a training cohort. The accuracy of the models was verified in a testing cohort and an independent external validation cohort. Model performance was evaluated using area under the curve (AUC), sensitivity, specificity, positive predictive value, and negative predictive value. Results: The model constructed with pre-NAT mpMRI had favorable accuracy for prediction of non-response to NAT in the training cohort (AUC = 0.84), testing cohort (AUC = 0.81), and external validation cohort (AUC = 0.79), which outperformed single-sequence MRI. The model constructed with both pre-NAT and post-NAT mpMRI had powerful diagnostic value for pathologic complete response (pCR) in the training cohort (AUC = 0.86), testing cohort (AUC = 0.87), and external validation cohort (AUC = 0.87), which outperformed single-phase mpMRI and MR tumor regression grade for identification of pCR. Conclusions: Models constructed with multiphase and multiparameter MRI were able to predict tumor response to NAT with high accuracy and robustness, which may assist in individualized management of LARC." @default.
• W4376125992 created "2023-05-12" @default.
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• W4376125992 date "2023-05-11" @default.
• W4376125992 modified "2023-10-16" @default.
• W4376125992 title "Multiphase and multiparameter MRI-based radiomics for prediction of tumor response to neoadjuvant therapy in locally advanced rectal cancer" @default.
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• W4376125992 doi "https://doi.org/10.21203/rs.3.rs-2910052/v1" @default.
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