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- W4376130130 endingPage "107180" @default.
- W4376130130 startingPage "107180" @default.
- W4376130130 abstract "Pulmonary hypertension due to left heart disease (PH-LHD) or group 2 PH is the most common and lethal form of PH, occurring secondary to left ventricular systolic or diastolic heart failure (HF), left-sided valvular diseases, and congenital abnormalities. It is subdivided into isolated postcapillary PH (IpcPH) and combined pre- and post-capillary PH (CpcPH), with the latter sharing many similarities with group 1 PH. CpcPH is associated with worse outcomes and increased morbidity and mortality when compared to IpcPH. Although IpcPH can be improved by treatment of the underlying LHD, CpcPH is an incurable disease for which no specific treatment exists, likely due to the lack of understanding of its underlying mechanisms. Furthermore, drugs approved for PAH are not recommended for group 2 PH, as they are either ineffective or even deleterious. With this major unmet medical need, a better understanding of mechanisms and the identification of effective treatment strategies for this deadly condition are urgently needed. This review presents relevant background of the molecular mechanisms underlying PH-LHD that could translate into innovative therapeutic targets and explores novel targets currently being evaluated in clinical trials." @default.
- W4376130130 created "2023-05-12" @default.
- W4376130130 creator A5045417032 @default.
- W4376130130 creator A5045468605 @default.
- W4376130130 creator A5064869902 @default.
- W4376130130 creator A5074716573 @default.
- W4376130130 creator A5091922796 @default.
- W4376130130 date "2023-08-01" @default.
- W4376130130 modified "2023-09-24" @default.
- W4376130130 title "The future of group 2 pulmonary hypertension: Exploring clinical trials and therapeutic targets" @default.
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