FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376131151> ?p ?o ?g. }

• W4376131151 endingPage "431" @default.
• W4376131151 startingPage "422" @default.
• W4376131151 abstract "The proper function of regulatory T cells (Tregs) to suppress inflammation requires homing to the correct tissue site. Resolution of autoimmune uveitis generates distinct programmed death receptor 1 (PD-1+) and T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT+) Tregs in an adenosine 2A receptor (A2Ar)-dependent manner found in the spleen. Where and how these Tregs migrate from the spleen to prevent uveitis is not known. In this work, we show that A2Ar-dependent Tregs migrated to the eye and secondary lymphoid tissue and expressed chemokine receptor (CCR)6 and CCR7. Suppression of autoimmune uveitis required CCR6 and CCR7 expression for TIGIT+ Tregs but not PD-1+ Tregs. Moreover, stimulation of A2Ar on T cells from patients showed a decreased capacity to induce TIGIT+ Tregs that expressed CCR6 or CCR7, and PD-1+ Treg that expressed CCR6. This work provides a mechanistic understanding of the homing requirements of each of these Treg populations. Importantly, this work is clinically relevant because patients with chronic autoimmune uveitis are unable to induce the Treg populations identified in mice that home to the target tissue. The proper function of regulatory T cells (Tregs) to suppress inflammation requires homing to the correct tissue site. Resolution of autoimmune uveitis generates distinct programmed death receptor 1 (PD-1+) and T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT+) Tregs in an adenosine 2A receptor (A2Ar)-dependent manner found in the spleen. Where and how these Tregs migrate from the spleen to prevent uveitis is not known. In this work, we show that A2Ar-dependent Tregs migrated to the eye and secondary lymphoid tissue and expressed chemokine receptor (CCR)6 and CCR7. Suppression of autoimmune uveitis required CCR6 and CCR7 expression for TIGIT+ Tregs but not PD-1+ Tregs. Moreover, stimulation of A2Ar on T cells from patients showed a decreased capacity to induce TIGIT+ Tregs that expressed CCR6 or CCR7, and PD-1+ Treg that expressed CCR6. This work provides a mechanistic understanding of the homing requirements of each of these Treg populations. Importantly, this work is clinically relevant because patients with chronic autoimmune uveitis are unable to induce the Treg populations identified in mice that home to the target tissue." @default.
• W4376131151 created "2023-05-12" @default.
• W4376131151 creator A5004828985 @default.
• W4376131151 creator A5005448653 @default.
• W4376131151 creator A5014092069 @default.
• W4376131151 creator A5029828074 @default.
• W4376131151 creator A5073077641 @default.
• W4376131151 creator A5084596592 @default.
• W4376131151 creator A5088589851 @default.
• W4376131151 creator A5089816990 @default.
• W4376131151 date "2023-08-01" @default.
• W4376131151 modified "2023-10-03" @default.
• W4376131151 title "A2Ar-dependent PD-1+ and TIGIT+ Treg cells have distinct homing requirements to suppress autoimmune uveitis in mice" @default.
• W4376131151 cites W1649565066 @default.
• W4376131151 cites W1970080131 @default.
• W4376131151 cites W1981700839 @default.
• W4376131151 cites W1991527836 @default.
• W4376131151 cites W1995858393 @default.
• W4376131151 cites W2003566453 @default.
• W4376131151 cites W2004718870 @default.
• W4376131151 cites W2011139656 @default.
• W4376131151 cites W2011534722 @default.
• W4376131151 cites W2016362524 @default.
• W4376131151 cites W2047550305 @default.
• W4376131151 cites W2055603849 @default.
• W4376131151 cites W2065717340 @default.
• W4376131151 cites W2083970208 @default.
• W4376131151 cites W2094795241 @default.
• W4376131151 cites W2097478351 @default.
• W4376131151 cites W2108151651 @default.
• W4376131151 cites W2142877732 @default.
• W4376131151 cites W2148554752 @default.
• W4376131151 cites W2155426437 @default.
• W4376131151 cites W2270793956 @default.
• W4376131151 cites W2553680852 @default.
• W4376131151 cites W2761998451 @default.
• W4376131151 cites W2984898490 @default.
• W4376131151 cites W3009230330 @default.
• W4376131151 cites W3011470684 @default.
• W4376131151 cites W3012538686 @default.
• W4376131151 cites W3191066281 @default.
• W4376131151 cites W3214415139 @default.
• W4376131151 cites W33090153 @default.
• W4376131151 cites W4312958607 @default.
• W4376131151 doi "https://doi.org/10.1016/j.mucimm.2023.04.005" @default.
• W4376131151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37164238" @default.
• W4376131151 hasPublicationYear "2023" @default.
• W4376131151 type Work @default.
• W4376131151 citedByCount "0" @default.
• W4376131151 crossrefType "journal-article" @default.
• W4376131151 hasAuthorship W4376131151A5004828985 @default.
• W4376131151 hasAuthorship W4376131151A5005448653 @default.
• W4376131151 hasAuthorship W4376131151A5014092069 @default.
• W4376131151 hasAuthorship W4376131151A5029828074 @default.
• W4376131151 hasAuthorship W4376131151A5073077641 @default.
• W4376131151 hasAuthorship W4376131151A5084596592 @default.
• W4376131151 hasAuthorship W4376131151A5088589851 @default.
• W4376131151 hasAuthorship W4376131151A5089816990 @default.
• W4376131151 hasBestOaLocation W43761311511 @default.
• W4376131151 hasConcept C127801297 @default.
• W4376131151 hasConcept C12823836 @default.
• W4376131151 hasConcept C13373296 @default.
• W4376131151 hasConcept C151872237 @default.
• W4376131151 hasConcept C18903297 @default.
• W4376131151 hasConcept C203014093 @default.
• W4376131151 hasConcept C2776090121 @default.
• W4376131151 hasConcept C2776194053 @default.
• W4376131151 hasConcept C2776914184 @default.
• W4376131151 hasConcept C2779118045 @default.
• W4376131151 hasConcept C71924100 @default.
• W4376131151 hasConcept C86803240 @default.
• W4376131151 hasConcept C8891405 @default.
• W4376131151 hasConcept C94205230 @default.
• W4376131151 hasConceptScore W4376131151C127801297 @default.
• W4376131151 hasConceptScore W4376131151C12823836 @default.
• W4376131151 hasConceptScore W4376131151C13373296 @default.
• W4376131151 hasConceptScore W4376131151C151872237 @default.
• W4376131151 hasConceptScore W4376131151C18903297 @default.
• W4376131151 hasConceptScore W4376131151C203014093 @default.
• W4376131151 hasConceptScore W4376131151C2776090121 @default.
• W4376131151 hasConceptScore W4376131151C2776194053 @default.
• W4376131151 hasConceptScore W4376131151C2776914184 @default.
• W4376131151 hasConceptScore W4376131151C2779118045 @default.
• W4376131151 hasConceptScore W4376131151C71924100 @default.
• W4376131151 hasConceptScore W4376131151C86803240 @default.
• W4376131151 hasConceptScore W4376131151C8891405 @default.
• W4376131151 hasConceptScore W4376131151C94205230 @default.
• W4376131151 hasFunder F4320306811 @default.
• W4376131151 hasFunder F4320310851 @default.
• W4376131151 hasFunder F4320332161 @default.
• W4376131151 hasFunder F4320332607 @default.
• W4376131151 hasFunder F4320337350 @default.
• W4376131151 hasIssue "4" @default.
• W4376131151 hasLocation W43761311511 @default.
• W4376131151 hasLocation W43761311512 @default.
• W4376131151 hasOpenAccess W4376131151 @default.
• W4376131151 hasPrimaryLocation W43761311511 @default.
• W4376131151 hasRelatedWork W1578385768 @default.

• next