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• W4376131189 abstract "Stroke has caused tremendous social stress worldwide, yet despite decades of research and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue plasminogen activator) is still the accepted treatment for ischemic stroke. the complexity of the stroke mechanism has led to unsatisfactory efficacy of most drugs in clinical trials, indicating that there are still many gaps in our understanding of stroke. Pyroptosis is a programmed cell death (PCD) with inflammatory properties and are thought to be closely associated with stroke. Pyroptosis is regulated by the GSDMD of the gasdermin family, which when cleaved by Caspase-1/Caspase-11 into N-GSDMD with pore-forming activity can bind to the plasma membrane to form small 10-20 nm pores, which would allow the release of inflammatory factors IL-18 and IL-1β before cell rupture, greatly exacerbating the inflammatory response. The pyroptosis occurs mainly in the border zone of cerebral infarction, and glial cells, neuronal cells and brain microvascular endothelial cells (BMECs) all undergo pyroptosis after stroke, which largely exacerbates the breakdown of the blood-brain barrier (BBB) and thus aggravates brain injury. Therefore, pyroptosis may be a good direction for the treatment of stroke. In this review, we focus on the latest mechanisms of action of pyroptosis and the process by which pyroptosis regulates stroke development. We also suggest potential therapeutic stroke drugs that target the pyroptosis pathway, providing additional therapeutic strategies for the clinical management of stroke. The role of pyroptosis after stroke. After stroke, microglia first rush to the damaged area and polarize into M1 and M2 types. Under the influence of various stimuli, microglia undergo pyroptosis, release pro-inflammatory factors, and are converted to the M1 type; astrocytes and neuronal cells also undergo pyroptosis under the stimulation of various pro-inflammatory factors, leading to astrocyte death due to increased osmotic pressure in the membrane, resulting in water absorption and swelling until rupture. BMECs, the main structural component of the BBB, also undergo pyroptosis when stimulated by pro-inflammatory factors released from microglia and astrocytes, leading to the destruction of the structural integrity of the BBB, ultimately causing more severe brain damage. In addition, GSDMD in neutrophils mainly mediate the release of NETs rather than pyroptosis, which also aggravates brain injury. IL-10=interleukin-10; TGF-β = transforming growth factor-β; IL-18=interleukin-18; IL-1β = interleukin-1β; TNF-α = tumor necrosis factor-α; iNOS=induced nitrogen monoxide synthase; MMPs=Matrix metalloproteinases; GSDMD = gasdermin D; BMECs=brain microvascular endothelial cells; BBB = blood-brain barrier." @default.
• W4376131189 created "2023-05-12" @default.
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• W4376131189 date "2023-05-10" @default.
• W4376131189 modified "2023-10-16" @default.
• W4376131189 title "Targeting pyroptosis as a preventive and therapeutic approach for stroke" @default.
• W4376131189 cites W1130611829 @default.
• W4376131189 cites W1518143481 @default.
• W4376131189 cites W1809000459 @default.
• W4376131189 cites W1882905539 @default.
• W4376131189 cites W1960087948 @default.
• W4376131189 cites W1997424221 @default.
• W4376131189 cites W2005410446 @default.
• W4376131189 cites W2030718548 @default.
• W4376131189 cites W2051658957 @default.
• W4376131189 cites W2106105150 @default.
• W4376131189 cites W2262503792 @default.
• W4376131189 cites W2263957136 @default.
• W4376131189 cites W2292727275 @default.
• W4376131189 cites W2346184067 @default.
• W4376131189 cites W2461915818 @default.
• W4376131189 cites W2462773201 @default.
• W4376131189 cites W2515398430 @default.
• W4376131189 cites W2527645962 @default.
• W4376131189 cites W2560319914 @default.
• W4376131189 cites W2565330593 @default.
• W4376131189 cites W2594333208 @default.
• W4376131189 cites W2606634094 @default.
• W4376131189 cites W2728764544 @default.
• W4376131189 cites W2762754198 @default.
• W4376131189 cites W2767960938 @default.
• W4376131189 cites W2768102094 @default.
• W4376131189 cites W2789018622 @default.
• W4376131189 cites W2789997601 @default.
• W4376131189 cites W2790139801 @default.
• W4376131189 cites W2791444686 @default.
• W4376131189 cites W2791564057 @default.
• W4376131189 cites W2791711864 @default.
• W4376131189 cites W2801598991 @default.
• W4376131189 cites W2808597917 @default.
• W4376131189 cites W2809894175 @default.
• W4376131189 cites W2888057265 @default.
• W4376131189 cites W2888168693 @default.
• W4376131189 cites W2891793399 @default.
• W4376131189 cites W2893932868 @default.
• W4376131189 cites W2895833591 @default.
• W4376131189 cites W2896993101 @default.
• W4376131189 cites W2900507152 @default.
• W4376131189 cites W2914524806 @default.
• W4376131189 cites W2920011597 @default.
• W4376131189 cites W2944262472 @default.
• W4376131189 cites W2945481468 @default.
• W4376131189 cites W2946298400 @default.
• W4376131189 cites W2947033822 @default.
• W4376131189 cites W2964003958 @default.
• W4376131189 cites W2970221764 @default.
• W4376131189 cites W2973160898 @default.
• W4376131189 cites W2982429121 @default.
• W4376131189 cites W2983652778 @default.
• W4376131189 cites W2985842440 @default.
• W4376131189 cites W2989252539 @default.
• W4376131189 cites W2991204446 @default.
• W4376131189 cites W2991483425 @default.
• W4376131189 cites W2995307142 @default.
• W4376131189 cites W3004297876 @default.
• W4376131189 cites W3008435276 @default.
• W4376131189 cites W3008585479 @default.
• W4376131189 cites W3010838109 @default.
• W4376131189 cites W3011405279 @default.
• W4376131189 cites W3011500848 @default.
• W4376131189 cites W3014629109 @default.
• W4376131189 cites W3016091053 @default.
• W4376131189 cites W3016811071 @default.
• W4376131189 cites W3022243693 @default.
• W4376131189 cites W3022448963 @default.
• W4376131189 cites W3022848360 @default.
• W4376131189 cites W3022981886 @default.
• W4376131189 cites W3024589383 @default.
• W4376131189 cites W3025175405 @default.
• W4376131189 cites W3026093678 @default.
• W4376131189 cites W3034916027 @default.
• W4376131189 cites W3036231704 @default.
• W4376131189 cites W3043236841 @default.

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