FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376131710> ?p ?o ?g. }

• W4376131710 abstract "Abstract Lentiviral vectors are attractive delivery vehicles for cystic fibrosis gene therapy owing to their low immunogenicity and ability to integrate into the host cell genome, thereby producing long-term, stable gene expression. Nonetheless, repeat dosing may be required to increase initial expression levels, and/or boost levels when they wane. The primary aim of this study was to determine if repeat dosing of a VSV-G pseudotyped LV vector delivered into mouse lungs is more effective than a single dose. C57Bl/6 mouse lungs were conditioned with lysophosphatidylcholine, followed one-hour later by a LV vector carrying the luciferase reporter gene, using six different short-term (≤1 wk) and long-term (>1 wk) dosing schedules. Luciferase expression was quantified using bioluminescence imaging over 12 months. Most dosing schedules produced detectable bioluminescence over the 12-month period, but the shorter intervals (≤1 wk) produced higher levels of flux than the longest interval (five doses at least 1-month apart). Ex vivo lung analysis at 12 months showed that the estimated mean flux for the group that received two doses 1-week apart was significantly greater than the single dose group and the two groups that received doses over a period greater than 1-week. These results suggest that early consecutive multiple doses are more effective at improving gene expression in mouse lungs at 12 months, than longer repeat dosing intervals." @default.
• W4376131710 created "2023-05-12" @default.
• W4376131710 creator A5011387086 @default.
• W4376131710 creator A5016955717 @default.
• W4376131710 creator A5059559110 @default.
• W4376131710 creator A5076206423 @default.
• W4376131710 creator A5078697553 @default.
• W4376131710 creator A5086442396 @default.
• W4376131710 creator A5086566564 @default.
• W4376131710 creator A5087531723 @default.
• W4376131710 date "2023-05-10" @default.
• W4376131710 modified "2023-10-03" @default.
• W4376131710 title "Repeat or single-dose lentiviral vector administration to mouse lungs? It’s all about the timing" @default.
• W4376131710 cites W1994064996 @default.
• W4376131710 cites W2008188840 @default.
• W4376131710 cites W2034753008 @default.
• W4376131710 cites W2086866768 @default.
• W4376131710 cites W2113402490 @default.
• W4376131710 cites W2116714531 @default.
• W4376131710 cites W2134929995 @default.
• W4376131710 cites W2146923102 @default.
• W4376131710 cites W2148019580 @default.
• W4376131710 cites W2151514148 @default.
• W4376131710 cites W2162527922 @default.
• W4376131710 cites W2732202264 @default.
• W4376131710 cites W2769701219 @default.
• W4376131710 cites W2775683477 @default.
• W4376131710 cites W2797610602 @default.
• W4376131710 cites W2903483240 @default.
• W4376131710 cites W2946651090 @default.
• W4376131710 cites W2962938491 @default.
• W4376131710 cites W2979759357 @default.
• W4376131710 cites W3047879827 @default.
• W4376131710 cites W3088925155 @default.
• W4376131710 cites W3093965116 @default.
• W4376131710 cites W3154641461 @default.
• W4376131710 cites W3158201984 @default.
• W4376131710 cites W3209141478 @default.
• W4376131710 cites W4205612199 @default.
• W4376131710 cites W4206755691 @default.
• W4376131710 cites W4236357753 @default.
• W4376131710 doi "https://doi.org/10.1038/s41434-023-00403-3" @default.
• W4376131710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37165031" @default.
• W4376131710 hasPublicationYear "2023" @default.
• W4376131710 type Work @default.
• W4376131710 citedByCount "2" @default.
• W4376131710 countsByYear W43761317102023 @default.
• W4376131710 crossrefType "journal-article" @default.
• W4376131710 hasAuthorship W4376131710A5011387086 @default.
• W4376131710 hasAuthorship W4376131710A5016955717 @default.
• W4376131710 hasAuthorship W4376131710A5059559110 @default.
• W4376131710 hasAuthorship W4376131710A5076206423 @default.
• W4376131710 hasAuthorship W4376131710A5078697553 @default.
• W4376131710 hasAuthorship W4376131710A5086442396 @default.
• W4376131710 hasAuthorship W4376131710A5086566564 @default.
• W4376131710 hasAuthorship W4376131710A5087531723 @default.
• W4376131710 hasBestOaLocation W43761317101 @default.
• W4376131710 hasConcept C104317684 @default.
• W4376131710 hasConcept C111335760 @default.
• W4376131710 hasConcept C111599444 @default.
• W4376131710 hasConcept C126322002 @default.
• W4376131710 hasConcept C150194340 @default.
• W4376131710 hasConcept C150903083 @default.
• W4376131710 hasConcept C161733203 @default.
• W4376131710 hasConcept C161997846 @default.
• W4376131710 hasConcept C16685009 @default.
• W4376131710 hasConcept C203014093 @default.
• W4376131710 hasConcept C207001950 @default.
• W4376131710 hasConcept C26291073 @default.
• W4376131710 hasConcept C2777288759 @default.
• W4376131710 hasConcept C2780868878 @default.
• W4376131710 hasConcept C32470452 @default.
• W4376131710 hasConcept C40767141 @default.
• W4376131710 hasConcept C54009773 @default.
• W4376131710 hasConcept C55493867 @default.
• W4376131710 hasConcept C71924100 @default.
• W4376131710 hasConcept C86803240 @default.
• W4376131710 hasConcept C8891405 @default.
• W4376131710 hasConcept C92087593 @default.
• W4376131710 hasConcept C98274493 @default.
• W4376131710 hasConceptScore W4376131710C104317684 @default.
• W4376131710 hasConceptScore W4376131710C111335760 @default.
• W4376131710 hasConceptScore W4376131710C111599444 @default.
• W4376131710 hasConceptScore W4376131710C126322002 @default.
• W4376131710 hasConceptScore W4376131710C150194340 @default.
• W4376131710 hasConceptScore W4376131710C150903083 @default.
• W4376131710 hasConceptScore W4376131710C161733203 @default.
• W4376131710 hasConceptScore W4376131710C161997846 @default.
• W4376131710 hasConceptScore W4376131710C16685009 @default.
• W4376131710 hasConceptScore W4376131710C203014093 @default.
• W4376131710 hasConceptScore W4376131710C207001950 @default.
• W4376131710 hasConceptScore W4376131710C26291073 @default.
• W4376131710 hasConceptScore W4376131710C2777288759 @default.
• W4376131710 hasConceptScore W4376131710C2780868878 @default.
• W4376131710 hasConceptScore W4376131710C32470452 @default.
• W4376131710 hasConceptScore W4376131710C40767141 @default.
• W4376131710 hasConceptScore W4376131710C54009773 @default.
• W4376131710 hasConceptScore W4376131710C55493867 @default.
• W4376131710 hasConceptScore W4376131710C71924100 @default.
• W4376131710 hasConceptScore W4376131710C86803240 @default.

• next